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UT Southwestern receives continued NIH funding for Inner City Asthma Consortium
Date:11/22/2009

DALLAS Nov. 23, 2009 UT Southwestern Medical Center is among 10 institutions selected by the National Institutes of Health to share $56 million over five years as part of the Inner City Asthma Consortium (ICAC).

The ICAC, which receives funding through the NIH's National Institute of Allergy and Infectious Diseases, investigates novel treatments and causes of asthma in urban children.

Dr. Rebecca Gruchalla, chief of allergy and immunology at UT Southwestern, said continued funding of the consortium is imperative because morbidity and mortality continues to be highest in inner-city children and adolescents with asthma. Dr. Gruchalla has led the Dallas arm of the ICAC for seven years.

"The proposed studies undertaken through our continued role in the ICAC are novel, innovative and likely to help us truly make a difference in the lives of inner-city children suffering from this often debilitating disease," Dr. Gruchalla said.

Ongoing studies include a prospective, longitudinal evaluation of environmental factors that influence the development of the immune system and asthma, as well as clinical trials of possible treatment therapies.

Previous ICAC-funded research has found that:

  • A coordinated, guidelines-based approach to asthma management quickly controls asthma among inner-city adolescents.
  • Adding exhaled nitric oxide to guidelines-based care does not improve clinical outcomes.
  • Screening tests used to predict asthma activity in some patients may have little tracking success when applied to people with persistent disease who are adhering to their health care regimens.

With continued NIH funding, Dr. Michelle Gill, assistant professor of pediatrics at UT Southwestern, is leading key mechanistic studies that explore how anti-IgE therapy can decrease viral-induced seasonal asthma exacerbations. IgE antibodies are the fuel in the immune system that perpetuates asthmatic reactions and
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Contact: Erin Prather Stafford
erin.pratherstafford@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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