Navigation Links
UT Southwestern launches clinical trial for treatment of breast cancer using CyberKnife
Date:2/15/2011

DALLAS Feb. 15, 2011 Breast-cancer patient Kristin Wiginton is the first to be treated at UT Southwestern Medical Center with high-beam radiation using the Accuray CyberKnife System, which offers improved cosmetic results, less radiation exposure to surrounding tissue and a shorter treatment period.

Dr. Wiginton is among 45 participants in a UT Southwestern-based clinical trial the first of its kind in the Southwest investigating use of the radiation delivery system for breast cancer. Her post-lumpectomy therapy lasted one-third the duration of a typical radiation session for a breast-cancer patient.

While CyberKnife has been used at UT Southwestern since 1997, it primarily has been targeted for tumors of the brain and spine.

"If this had not worked out for me, I would have gone with six and a half weeks of traditional radiation," said Dr. Wiginton, 45, an associate professor of health studies at Texas Woman's University.

Instead, her treatment took less than two weeks and consisted of five 90-minute sessions every two to three days. Her final treatment was Feb. 3 at UT Southwestern University Hospital - Zale Lipshy.

Radiation therapy following a lumpectomy is commonly recommended to remove potential residual cancer, said Dr. Robert Timmerman, professor of radiation oncology and neurological surgery who is leading the study. Current radiation protocols for breast cancer, however, can be long and uncomfortable. Shorter courses treating smaller breast volumes, called partial breast irradiation, have shown considerable promise in clinical studies, he said. The most common partial breast irradiation approach, brachytherapy, requires a catheter implant via a surgical procedure. Another method delivers the treatment using conventional radiotherapy equipment but may lead to less-pleasing cosmetic results.

Dr. Wiginton described her first CyberKnife session as painless. Though a bit tired, she said the treatment was not uncomfortable and she spent most of the time listing to music on her iPod.

"You don't have to worry about moving too much, because you are put into a mold," she said, referring to a special padded bed she rested on during the procedure.

The trial's protocol is being carried out in conjunction with experts in the UT Southwestern Center for Breast Care at the Harold C. Simmons Cancer Center, the only National Cancer Institute-designated center in North Texas.

Patients preparing for CyberKnife radiation treatments have minute gold seed markers called fiducials implanted around the affected breast tissue. The CyberKnife's image-guided system tracks the fiducials to deliver radiation to the area, including moving with each breath taken by the patient.

Instead of standard radiation therapy systems that require heavy equipment with very limited maneuverability and beam direction, CyberKnife uses a lighter linear accelerator on a robotic arm to focus multiple beams of radiation with a millimeter precision, while leaving surrounding healthy tissue unharmed.

"The impetus for this protocol is to avoid that invasiveness while still achieving excellent cosmetic results," said Dr. Timmerman, referring to the typical brachytherapy procedure. "This gives the same amount of radiation, but in a noninvasive way. Each [CyberKnife-delivered] beam is very weak, so it causes very little entry damage. It will move around to 200 different positions."

Qualified participants must have localized early-stage breast cancer, must have successfully underwent a lumpectomy and be at least 18 years old. Patients will be evaluated over the next 10 years to check if they remain cancer-free, for potential cosmetic changes in the breast and any unanticipated effects that may develop from radiation treatment.

Dr. Wiginton, referred for the study by Dr. Dan Garwood, associate professor of radiation oncology, said she hopes the procedure will be successful and offer new radiation therapy options for breast-cancer patients.

Because heart disease ran her family, traditional radiation therapy wasn't a good choice for Dr. Wiginton due to potential damage to surrounding tissues, including the heart. CyberKnife's precision greatly lessened that risk.

"If they're willing to use it on brain cancer, I think it's a fairly safe bet to use in a breast," Dr. Wiginton said.


'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Homogeneous tuberculosis treatment ineffective in children, UT Southwestern researchers find
2. New clues uncover how starvation hormone works, investigators at UT Southwestern report
3. Circuit regulating anti-diabetic actions of serotonin uncovered by UT Southwestern researchers
4. Temperature rhythms keep body clocks in sync, UT Southwestern researchers find
5. UT Southwestern study to determine whether leptin helps type 1 diabetes patients
6. UT Southwestern researchers create experimental vaccine against Alzheimers
7. Blood test could diagnose Alzheimers disease, UT Southwestern researchers find
8. NIH awards $8 million to UT Southwestern to study metabolism, obesity-related inflammation
9. Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
10. UT Southwestern University Hospital -- St. Paul recognized as Primary Stroke Center
11. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released ... failing their residents by lacking a comprehensive, proven plan to eliminate ... a definitive ranking of how states are tackling the worst drug ... only four states – Kentucky , ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
Breaking Medicine Technology: