Navigation Links
UT MD Anderson study finds link between statins and improved survival in inflammatory breast cancer
Date:12/6/2012

HOUSTON - Researchers from The University of Texas MD Anderson Cancer Center found statins, the commonly used drug to lower cholesterol, improved progression-free survival in patients with inflammatory breast cancer (IBC).

The retrospective study was presented today in a poster discussion at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium and follows a previously reported Danish study indicating there is some evidence to suggest the anti-inflammatory properties of statins could reduce the risk of breast cancer recurrence. Still, the overall effects of statins have not been examined in relation to IBC.

IBC is a rare type of breast cancer that develops quickly when malignant cells block lymph vessels in the skin and soft tissue. It accounts for only 1-5 percent of all invasive breast cancers, according to the American Cancer Society.

"We decided to take a different approach with the smaller population of inflammatory breast cancer patients and see if it's truly an inflammatory disease, whether or not there's some substantial impact of statin use in this population," said Naoto T. Ueno, M.D., Ph.D., professor in MD Anderson's Department of Breast Medical Oncology and executive director of the Morgan Welch Inflammatory Breast Cancer Research Program and Clinic.

Ueno, the corresponding author, and his colleagues reviewed 724 patients diagnosed and treated for stage III inflammatory breast cancer at MD Anderson between 1995 and 2011. Patients with records indicating statin use at the time of diagnosis were compared to those who were not taking statins. In total, the stage III group contained 74 statin users and 650 non-users.

The primary end-point was progression-free survival (PFS), while secondary end-points measured overall survival (OS) and disease-specific survival (DSS).

Additionally, researchers compared the clinical outcomes of those in the statin group based on the type of statin, lipophilic (fat-soluble) or hydrophilic (water-soluble), an important distinction as differences in survival emerged throughout the trial. The authors note patients who used both drug categories, or patients missing information on their specific statin type, were excluded from the survival estimates.

Outcomes Show Improvement

Patients with no record of statin use had 1.76 years DFS, while patients who took lipophilic statins saw improved survival rates of 2.47 years. The greatest improvement in survival was noted in patients with past hydrophilic statin use at 4.88 years.

Increased survival rates also extended to the DSS end-point. Patients with no statin use measured a DSS of 4.52 years, while hydrophilic patients measured 5.10 years.

The authors note there is a trend in overall survival, however the OS end-point did not reach statistical significance.

"The previous Danish study looking at statins examined a much larger group of participants, around 10,000 and more. So we're talking about a much smaller set of inflammatory breast cancer patients and to see the significant improvement in survival gives us a new perspective on the use of statins," said Ueno.

While Ueno added the findings are encouraging, the study does have limitations. First, no data was available describing how long patients had been taking statins, or for what indication. Those who did use statins may represent a population with better access to health care, a more health-conscious lifestyle and a higher education level, according to the researchers.

"This is an existing drug that was not developed for cancer and while developing new agents is important, statins are currently in the market and may have a significant role in the treatment we provide," he said.

Additional Research Warranted

MD Anderson researchers are planning prospective randomized studies in IBC patients to better evaluate the potential survival benefits of statins. Further studies also hope to identify what subset of populations would be best suited for statin use. Ueno said there is an important convenience factor involved, as participants can take statins anywhere and require only occasional follow-up.


'/>"/>
Contact: William Fitzgerald
wbfitzgerald@mdanderson.org
713-792-9518
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. UT MD Anderson study finds cancer related pain often undertreated
2. University of Houston Graduate College of Social Work announces partnership with MD Anderson
3. UT MD Anderson President Ronald DePinho elected to National Academy of Sciences
4. UT MD Anderson study finds link between depressive symptoms and cancer survival
5. UT MD Anderson Cancer Center launches unprecedented Moon Shots Program
6. Study Suggests Vaccine May Help Kids With Brain Cancer
7. Study reveals how cancer drug causes diabetic-like state
8. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
9. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
10. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
11. No Added Cancer Risk From Hip Replacement Materials: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT MD Anderson study finds link between statins and improved survival in inflammatory breast cancer
(Date:1/17/2017)... New York, NY (PRWEB) , ... January 17, 2017 , ... ... the grand opening of a new showroom at South Dixie Hwy in Miami, FL. ... Marketing Officer at Gym Source. “The new innovative in-store concept is designed to give ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... by the political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting interview with medical ... moments that help everyone endure and pass through tough times, Dr. Bernie Siegel ...
(Date:1/17/2017)... ... January 17, 2017 , ... Kevin Harrington (one of the original ... featuring DRTV campaigns regarding the topic of Beauty and Personal Care. ... themselves. What better way to commit to these changes than beginning with personal care ...
(Date:1/17/2017)... ... January 17, 2017 , ... Achieve TMS ... is opening a new office in San Clemente, California this month. Achieve TMS ... Southern California, successfully treating individuals struggling with major depression. Depression impacts over 15 ...
(Date:1/17/2017)... ... January 17, 2017 , ... Peoples ... the Peoples Health network on Dec. 1, 2016. Peoples Health, a Metairie-based Medicare ... Center is an exciting addition to our provider network, and the addition will ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... 17, 2017 Secretary of Health Dr. ... Gary Tennis are warning Pennsylvanians of the ... overdose deaths from the drug in Beaver ... to sedate large animals and is not meant for ... into contact with it," Secretary Murphy said. "It,s absolutely ...
(Date:1/17/2017)... EU5 Glucose Monitoring Market Outlook to 2022 ... Monitoring Market Outlook to 2022", provides key market data ... value, in millions of US dollars, volume (in units) ... Glucose Meters, Blood Glucose Test Strips and Lancets. ... data for each of these market segements, and global ...
(Date:1/17/2017)... Jan. 17, 2017 The interventional radiology products ... 2021 from USD 6.35 billion in 2016, at a ... growth of this market are rising incidence of chronic ... invasive surgeries. The global interventional radiology products ... region. On the basis of type, the stents segment ...
Breaking Medicine Technology: