Navigation Links
UT MD Anderson study finds link between depressive symptoms and cancer survival
Date:8/3/2012

HOUSTON Research from The University of Texas MD Anderson Cancer Center has found that symptoms of depression in patients with newly diagnosed metastatic kidney cancer are associated with survival and inflammatory gene regulation may explain this link.

The study, published in the journal PLoS ONE, further explores the interplay between patient psychological condition, stress hormone regulation and the role of inflammatory gene expression. Although previous research indicates depression is connected with worse outcomes, questions remain about the specific factors involved.

"Our findings, and those of others, suggest that mental health and social well-being can affect biological processes, which influence cancer-related outcomes," said Lorenzo Cohen, Ph.D., professor in MD Anderson's Departments of General Oncology and Behavioral Science and director of the Integrative Medicine Program. "They also suggest that screening for mental health should be part of standard care because there are well accepted ways of helping people manage distress, even in the face of a life threatening illness.

"We were particularly interested in examining psychosocial factors as predictors of survival," Cohen continued. "Our findings indicate that we're now able to understand some of the possible biological pathways that explain the association between depression and survival."

Cohen, the lead author, and his colleagues examined 217 MD Anderson patients with newly diagnosed metastatic renal cell carcinoma from April 2000 November 2005. At study entry, patients completed a number of questionnaires and provided blood samples.

The surveys measured depressive symptoms, general quality of life, social support, coping, religiosity and spirituality.

Participants also provided five saliva samples per day for three days to evaluate fluctuations of cortisol, the stress hormone that should be high in the morning and drop throughout the course of the day. Increased cortisol levels have been found in patients with depressive symptoms and are linked to cellular alterations, Cohen said.

At the time of analysis, 64 percent of patients were deceased and for those who died, the average time from diagnosis to death was 1.8 years. Overall, 23 percent of patients reported depressive symptoms within a clinical range (scores of 16 or higher) and this was associated with shorter survival time, even after controlling for disease-related risk factors. Similarly, a flattened cortisol slope from morning to evening was related to shorter survival time.

Signaling Pathways Unlock Clues

To determine whether the increased mortality risk associated with elevated depressive symptoms might stem from pro-inflammatory gene expression, whole-genome profiling was conducted on tissue samples from 15 patients with the highest depressive symptoms and 15 risk-matched patients with the lowest depressive symptom scores.

"We know specific signaling pathways like NF-ĸB play a critical role in regulating inflammation within cells," said Anil Sood, M.D., professor in MD Anderson's Department of Gynecologic Oncology and a co-author on the study. "Our goal was to determine if these pathways were expressed at greater levels in patients with depressive symptoms and we found data indicating they were."

In total, 116 genetic transcripts were found to be upregulated by an average of 50 percent or more in patients with high depressive symptoms, according to the study. The data suggest the association between patient psychological condition and survival time may stem from a dysregulation in inflammatory biology and cortisol slope.

Future Studies Are Needed

The authors note a number of limitations to the study, including the difficulty to determine causality between psychological stress and cancer survival in human models, as inducing stress would be unethical. It's also possible there are other factors that could influence depressive symptoms and survival that were not addressed in the study. Additionally, whether high levels of stress were present before a patient's diagnosis will require additional attention, said Cohen.

The next step is to conduct clinical trials to evaluate whether the management of depression using behavioral techniques or pharmacologic interventions can influence survival in patients with mild, moderate or severe mood disorders and a cancer diagnosis, Cohen said.


'/>"/>
Contact: William Fitzgerald
wbfitzgerald@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. UT MD Anderson President Ronald DePinho elected to National Academy of Sciences
2. University of Houston Graduate College of Social Work announces partnership with MD Anderson
3. UT MD Anderson study finds cancer related pain often undertreated
4. Killer infections targeted by hospital study
5. Alzheimers Progression Slower After 80: Study
6. When Parents Get Active, So Do Kids: Study
7. Diverted Medical Marijuana Use Common Among Teens: Study
8. Most Americans With Celiac Disease Dont Realize It: Study
9. Studying couples to improve health, better relationships
10. Common Skin Cancer a Chronic Condition, Study Says
11. Breast Cancer Drug Duo Wins Out in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... California (PRWEB) , ... June 25, 2016 , ... "With ... fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... customizable and all within Final Cut Pro X . Simply select a ProHand ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... 2022" report to their offering. ... with kidney failure, it replaces the function of kidneys by ... and thus the treatment helps to keep the patient body,s ... Increasing number of ESRD patients & substantial healthcare ...
Breaking Medicine Technology: