Navigation Links
UT MD Anderson scientists find protein that reins in runaway network
Date:1/22/2013

erges

Sun and colleagues had a candidate, the enzyme OTUD7B, also known by its more lyrical name, Cezanne. It was genetically quite similar to another enzyme active in the canonical pathway for NF-kB called A20. Both were known deubiquitinases, enzymes that cleave ubiquitin polymers. A20 is not active in the non-canonical NFkB pathway.

By applying inducers of the non-canonical NK-kB pathway to cells derived from OTUD7B-deficient mice, the researchers found:

  • Degradation of TRAF3 and accumulation of its target, NIK
  • Ubiquitination of TRAF3

Cells with OTUD7B intact suppressed non-canonical NF-kB signaling.

Varied immune effects in mice

Knocking out the OTUD7B gene caused biological changes in mice, but it did not kill them, as occurs when A20 is knocked out.

Mice with OTUD7B suppressed had greatly increased lymphoid cell growth in the lining of the intestine and hyper-responsiveness to antigens by B cells. "If these two symptoms occur persistently, as they did in the knockout mice, they may contribute to autoimmunity or inflammation," Sun said.

However, knockout mice also had an improved immune response to the lethal intestinal bacterial pathogen C. rodentium. All of the mice with normal OTUD7B died of the bacterial infection, while 75 percent of the knockout mice survived.

Teasing out the reasons for these effects and developing OTUD7B as a target for inhibitors to boost immunity in the lining of the intestine will take more research, Sun said.

"It's important to know that TRAF3 has opposing roles in regulating activation of T cells and B cells, indicating that OTUD7B has a cell-type specific function. So, as with many other research findings, it might take considerably more effort to assess the therapeutic potential of OTUD7B," Sun said.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UT MD Anderson, GlaxoSmithKline to collaborate on new approach to cancer immune therapy
2. Horner Flooring to provide court for the MD Anderson Proton Therapy Showcase in Houston.
3. UT MD Anderson study finds link between statins and improved survival in inflammatory breast cancer
4. UT MD Anderson Cancer Center launches unprecedented Moon Shots Program
5. UT MD Anderson study finds link between depressive symptoms and cancer survival
6. UT MD Anderson President Ronald DePinho elected to National Academy of Sciences
7. University of Houston Graduate College of Social Work announces partnership with MD Anderson
8. UT MD Anderson study finds cancer related pain often undertreated
9. Study Finds Older Male Scientists Likelier to Commit Research Fraud
10. NIH scientists identify protective role for antibodies in Ebola vaccine study
11. Johns Hopkins neuroscientists win National Academy of Science Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... CALNOC, the nation’s first nursing quality indicators ... will keynote their upcoming conference – Navigating the Chaos ... October 26, 2015. , Dr. Burnes Bolton is ... Executives (AONE) and the first African American to hold ... of Nursing and the National Black Nurses Association, she ...
(Date:4/21/2015)... VA (PRWEB) April 21, 2015 The Science ... as a special addition to its Lunch Break Science program. ... World of Quarks! – taking guests from the subatomic world ... form. , The Museum invites members of the community to ... the Jefferson Lab physicist. Guests will delve into the nucleus ...
(Date:4/21/2015)... Renewable energy, sustainable living, the greening ... Earth Day topics USM Studios ’ programming covers ... the affect of climate change on the planet, the ... touching on the environmental concerns affecting the nation and ... sustainable lifestyles, clean air options, and much more when ...
(Date:4/21/2015)... GA (PRWEB) April 21, 2015 On ... Segal and the rest of his team from ... annual Walk to End Lupus Now, being held in ... year’s Atlanta Walk proved to be the largest LFA-sponsored ... in an effort to raise funds and awareness for ...
(Date:4/21/2015)... San Antonio, TX (PRWEB) April 21, 2015 ... commercialization rights from a prestigious Illinois university for ... intensive care units (NICUs) more conducive to newborn ... of the top three NICU problems we have ... of neonatal care professionals,” said George Hutchinson, Invictus ...
Breaking Medicine News(10 mins):Health News:Nationally Recognized Nurse Leader Linda Burnes Bolton to Present Keynote Address at CALNOC Conference 2Health News:Quarks and Forks at the Science Museum of Virginia 2Health News:USM Studios’ Programming Focuses on the Environment 2Health News:9th Annual Walk to End Lupus Now 2Health News:9th Annual Walk to End Lupus Now 3Health News:Invictus Medical Secures Rights to Second Promising New NICU Technology 2
... HealthDay Reporter , MONDAY, April 30 (HealthDay News) -- About ... called opiates in the United States, a new study shows. ... syndrome called neonatal abstinence syndrome tripled between 2000 and 2009, ... online April 30 in the Journal of the American ...
... 1 (HealthDay News) -- Many asthmatic children in the United ... problems because of it, a new study shows. "National ... patients with asthma for decades, but it is unclear to ... impact of exposure has been in an era of increased ...
... May 1, 2012 (Chevy Chase, MD) Women going ... help them better understand their menu of treatment options, ... The Endocrine Society and its Hormone Health Network today ... women and their doctors discuss which hormonal and non-hormonal ...
... BOSTON Despite longstanding recommendations for children with asthma ... to secondhand smoke and their health suffers because of ... May 1, at the Pediatric Academic Societies (PAS) annual ... advised avoidance of environmental tobacco smoke (ETS) for patients ...
... who have learning, attention and behavior problems may be ... show them sleeping long enough at night, a new ... and found that those whose parents reported excessive daytime ... from traditional measurements were more likely to experience ...
... imaging department (with dedicated pediatric computed tomography (CT) technologists) for ... the patient, according to a study in the May issue ... When performed and monitored ... risk of radiation. To minimize the potential adverse effects of ...
Cached Medicine News:Health News:U.S. Sees Tripling of Babies Born Addicted to Painkillers 2Health News:U.S. Sees Tripling of Babies Born Addicted to Painkillers 3Health News:Many Asthmatic Kids Harmed by Secondhand Smoke: Study 2Health News:First-of-its-kind 'Menopause Map' helps women navigate treatment 2Health News:First-of-its-kind 'Menopause Map' helps women navigate treatment 3Health News:First-of-its-kind 'Menopause Map' helps women navigate treatment 4Health News:Secondhand smoke continues to vex children with asthma 2Health News:Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose 2
(Date:4/20/2015)... 2015   Precision Image Analysis (PIA) is ... advances in cardiovascular imaging and post-processing. Scott D. ... Society for Cardiovascular Magnetic Resonance (SCMR) will be ... patient management by providing broader access to Cardiac MRI ... to better understand appropriate use of CMR, the strengths ...
(Date:4/20/2015)... April 20, 2015  Sigma-Aldrich Corporation (Nasdaq: ... (CR) Magazine,s list of the 100 Best Corporate ... corporate responsibility performance.  Sigma-Aldrich ranked fifth, its highest ... the list. "We are honored to ... efforts and we are extremely pleased with our ...
(Date:4/20/2015)... N.J. , April 20, 2015  Johnson & ... of its Pharmaceutical business for the investment community beginning ... 2015 at the Hyatt Regency Hotel in ... approximately 3:00 p.m. Paul Stoffels , ... Joaquin Duato , Worldwide Chairman, Pharmaceuticals will host ...
Breaking Medicine Technology:Educational Webinar Teaches Improved Patient Management Through Broader Access to Cardiac MRI 2Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2
... Actavis, an international generic pharmaceutical company, today announced that ... CII, an authorized generic of KADIAN®*. Actavis ... in-depth expertise in the development and manufacturing of complex ... grown 50% in the last 5 years to approximately ...
... Lotus Pharmaceuticals, Inc. (OTCBB: LTUS) ("Lotus" or the "Company"), ... in the People,s Republic of China ("PRC"), today announced its ... 2011. Summary financial data is provided below: ... Highlights Revenues for the third quarter of ...
Cached Medicine Technology:Actavis Launches Generic KADIAN® Capsules in the U.S. 2Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 2Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 3Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 4Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 5Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 6
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: