Navigation Links
UT MD Anderson scientists find protein that reins in runaway network
Date:1/22/2013

erges

Sun and colleagues had a candidate, the enzyme OTUD7B, also known by its more lyrical name, Cezanne. It was genetically quite similar to another enzyme active in the canonical pathway for NF-kB called A20. Both were known deubiquitinases, enzymes that cleave ubiquitin polymers. A20 is not active in the non-canonical NFkB pathway.

By applying inducers of the non-canonical NK-kB pathway to cells derived from OTUD7B-deficient mice, the researchers found:

  • Degradation of TRAF3 and accumulation of its target, NIK
  • Ubiquitination of TRAF3

Cells with OTUD7B intact suppressed non-canonical NF-kB signaling.

Varied immune effects in mice

Knocking out the OTUD7B gene caused biological changes in mice, but it did not kill them, as occurs when A20 is knocked out.

Mice with OTUD7B suppressed had greatly increased lymphoid cell growth in the lining of the intestine and hyper-responsiveness to antigens by B cells. "If these two symptoms occur persistently, as they did in the knockout mice, they may contribute to autoimmunity or inflammation," Sun said.

However, knockout mice also had an improved immune response to the lethal intestinal bacterial pathogen C. rodentium. All of the mice with normal OTUD7B died of the bacterial infection, while 75 percent of the knockout mice survived.

Teasing out the reasons for these effects and developing OTUD7B as a target for inhibitors to boost immunity in the lining of the intestine will take more research, Sun said.

"It's important to know that TRAF3 has opposing roles in regulating activation of T cells and B cells, indicating that OTUD7B has a cell-type specific function. So, as with many other research findings, it might take considerably more effort to assess the therapeutic potential of OTUD7B," Sun said.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UT MD Anderson, GlaxoSmithKline to collaborate on new approach to cancer immune therapy
2. Horner Flooring to provide court for the MD Anderson Proton Therapy Showcase in Houston.
3. UT MD Anderson study finds link between statins and improved survival in inflammatory breast cancer
4. UT MD Anderson Cancer Center launches unprecedented Moon Shots Program
5. UT MD Anderson study finds link between depressive symptoms and cancer survival
6. UT MD Anderson President Ronald DePinho elected to National Academy of Sciences
7. University of Houston Graduate College of Social Work announces partnership with MD Anderson
8. UT MD Anderson study finds cancer related pain often undertreated
9. Study Finds Older Male Scientists Likelier to Commit Research Fraud
10. NIH scientists identify protective role for antibodies in Ebola vaccine study
11. Johns Hopkins neuroscientists win National Academy of Science Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... In an ... are hospitalized, Dr. Aggarwal is making a change in his practice. , The decision ... Effective August 14, 2015, Dr. Aggarwal will be transferring his in-patient admissions to the ...
(Date:7/30/2015)... NY (PRWEB) , ... July 30, 2015 , ... ... and Sustamine® L-Alanyl-L-Glutamine for people on the go. With no water needed, the ... Chewable as a simple way to get the natural ingredients that may help ...
(Date:7/30/2015)... MD (PRWEB) , ... July 30, 2015 , ... ... serving the Mid-Atlantic region, is the recipient of three awards in the Service ... for communications programs created for Choptank Transport, KRM Development Corporation and University of ...
(Date:7/30/2015)... CA (PRWEB) , ... July 30, 2015 , ... ... been consistently growing into one of the largest, family-owned low cost service and ... residential and commercial applications, as well as growing their company to meet the ...
(Date:7/30/2015)... ... July 30, 2015 , ... 24/7 Care At Home, a high-quality ... Bernardino, recently announced that the Centers for Medicare and Medicaid (CMS) have awarded its ... care providers. 24/7 Care At Home’s agency is one of three top Orange County ...
Breaking Medicine News(10 mins):Health News:River Valley Physician Dr. Aggarwal is Making Changes to his Practice 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 3Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 4Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 2Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 3Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 2Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 3Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2
... The Los Angeles Ronald McDonald,House, a ... and other serious illnesses, opened a newly-built ... from its original Fountain Avenue location.,Together, the ... free, lodging to,75-families per night; an increase ...
... 5 Years, ISTANBUL, Turkey, April 10 ... enrolled in a landmark, multi-national study that will,focus ... Launch of the,Global Longitudinal Registry of Osteoporosis in ... European Congress on Clinical and Economic Aspects,of Osteoporosis ...
... week, including housework, is good for mental health , , WEDNESDAY, April ... housework may clean your house and boost your mood. ... of physical activity a week helped mental health, although the more ... a study published online Thursday in the British Journal of ...
... OCEANSIDE, Calif., April 9 Healthcare,workers at Tri-City ... from the State Mediation & Conciliation Service,confirmed that ... majority of union authorization cards., TCMC caregivers ... West,and join thousands of other healthcare workers who ...
... that features four,leading experts in health information management ... to the privacy and security of health,information-and ways ... issues --,is now available., "Online, on Message, ... report,( http://www.ahima.org/emerging_issues/2008PrivacyRoundtable.pdf ) that will,be released in conjunction ...
... HOUSTON, April 9, 2008 One month of tough breathing ... according to research from one University of Houston professor. ... most basic tenets of the Hippocratic Oath first do ... UH, is relying on a long-standing medical taboo to treat ...
Cached Medicine News:Health News:Los Angeles Ronald McDonald House Doubles Lodging Capacity for Families of Hospitalized Children 2Health News:Los Angeles Ronald McDonald House Doubles Lodging Capacity for Families of Hospitalized Children 3Health News:Landmark Study Aims to Improve Osteoporosis Care Standards Worldwide 2Health News:Landmark Study Aims to Improve Osteoporosis Care Standards Worldwide 3Health News:Whisk Those Blues Away 2Health News:North County Caregivers Join United Healthcare Workers 2Health News:Privacy Experts' Roundtable Report Will Highlight Privacy & Security Week 2Health News:First do no harm? UH prof taking opposite approach to treat asthma 2Health News:First do no harm? UH prof taking opposite approach to treat asthma 3Health News:First do no harm? UH prof taking opposite approach to treat asthma 4
(Date:7/30/2015)... 30, 2015  ResMed (NYSE: RMD ... definitive agreement to acquire Curative Medical, a ... sleep-disordered breathing medical devices and accessories. ... with ResMed,s global leadership in sleep and respiratory medicine, ... China suffering from sleep-disordered breathing ...
(Date:7/30/2015)... 2015  Today we bring you a special edition of #MedicareMonday on Medicare,s 50 ... some of our Medicare resources and continue highlighting the success of the prescription drug ... Check out our latest infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... 30, 2015  Amgen (NASDAQ: AMGN ) today announced ... director of Warburg Pincus LLC, to the Amgen Board of ... Fred Hassan and the deep, global experience he brings ... Robert A. Bradway , chairman and chief executive officer of Amgen. ... serve Amgen well." Mr. Hassan has been Partner ...
Breaking Medicine Technology:ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3
... , ... ... , ... , , , ...
... ... ... ... ...
Cached Medicine Technology:RoundTable Healthcare Partners Names Charles W. Stiefel as Senior Advisor 2RoundTable Healthcare Partners Names Charles W. Stiefel as Senior Advisor 3Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 2Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 3Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 4Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 5Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 6Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 7Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 8Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 9Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 10Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 11Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 12Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 13Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 14Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 15Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 16Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 17Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 18Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 19Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 20Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 21Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 22Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 23Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 24Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 25Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 26Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 27Reportlinker Adds U.S. Market for Hearing Aids and Audiology Devices 2010 (Includes Audiologist Survey) 28
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: