Navigation Links
UT MD Anderson scientists find protein that reins in runaway network
Date:1/22/2013

erges

Sun and colleagues had a candidate, the enzyme OTUD7B, also known by its more lyrical name, Cezanne. It was genetically quite similar to another enzyme active in the canonical pathway for NF-kB called A20. Both were known deubiquitinases, enzymes that cleave ubiquitin polymers. A20 is not active in the non-canonical NFkB pathway.

By applying inducers of the non-canonical NK-kB pathway to cells derived from OTUD7B-deficient mice, the researchers found:

  • Degradation of TRAF3 and accumulation of its target, NIK
  • Ubiquitination of TRAF3

Cells with OTUD7B intact suppressed non-canonical NF-kB signaling.

Varied immune effects in mice

Knocking out the OTUD7B gene caused biological changes in mice, but it did not kill them, as occurs when A20 is knocked out.

Mice with OTUD7B suppressed had greatly increased lymphoid cell growth in the lining of the intestine and hyper-responsiveness to antigens by B cells. "If these two symptoms occur persistently, as they did in the knockout mice, they may contribute to autoimmunity or inflammation," Sun said.

However, knockout mice also had an improved immune response to the lethal intestinal bacterial pathogen C. rodentium. All of the mice with normal OTUD7B died of the bacterial infection, while 75 percent of the knockout mice survived.

Teasing out the reasons for these effects and developing OTUD7B as a target for inhibitors to boost immunity in the lining of the intestine will take more research, Sun said.

"It's important to know that TRAF3 has opposing roles in regulating activation of T cells and B cells, indicating that OTUD7B has a cell-type specific function. So, as with many other research findings, it might take considerably more effort to assess the therapeutic potential of OTUD7B," Sun said.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UT MD Anderson, GlaxoSmithKline to collaborate on new approach to cancer immune therapy
2. Horner Flooring to provide court for the MD Anderson Proton Therapy Showcase in Houston.
3. UT MD Anderson study finds link between statins and improved survival in inflammatory breast cancer
4. UT MD Anderson Cancer Center launches unprecedented Moon Shots Program
5. UT MD Anderson study finds link between depressive symptoms and cancer survival
6. UT MD Anderson President Ronald DePinho elected to National Academy of Sciences
7. University of Houston Graduate College of Social Work announces partnership with MD Anderson
8. UT MD Anderson study finds cancer related pain often undertreated
9. Study Finds Older Male Scientists Likelier to Commit Research Fraud
10. NIH scientists identify protective role for antibodies in Ebola vaccine study
11. Johns Hopkins neuroscientists win National Academy of Science Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... encourages people to keep their "eyes on the prize" ... When walking, staying focused on a specific target ahead ... help people walk there faster, psychology researchers have found. ... looking around the environment naturally, offers a new strategy ... less interested in exercise if physical activity seems daunting, ...
(Date:10/1/2014)... 01, 2014 Lifeinsurance-policy.com has released ... best life insurance prices for smokers. , Smoking will ... premiums. Comparing quotes is the best method to find ... for customers who need coverage. , Whole life ... of the policy. Since the coverage is permanent, the ...
(Date:10/1/2014)... Join the more than 80 golfers who already have ... charity golf tournament to benefit Project HEAL, a not-for-profit organization ... afford treatment. The tournament will be held Monday, Oct. 6, ... The day-long event starts with 10:30 a.m. check-in and shotgun ... begin at 5 p.m. and will include an auction featuring ...
(Date:10/1/2014)... Diet Doc understands that many of their clients have ... dieting attempts could be easily sabotaged by the temptation to ... into their programs as a way to control the ... weight loss results, it also allows patients to stick with ... weight for the future. , Earlier versions of the hormone ...
(Date:10/1/2014)... the occasion of the Leishmaniasis East Africa Platform ... international leishmaniasis experts, results of a pharmacovigilance ... plan, carried out by MSF, DNDi, and national ... presented to key decision makers in order to ... the combination of Sodium Stibogluconate and Paromomycin (SSG&PM) ...
Breaking Medicine News(10 mins):Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2
... Patricia Hewitt, will call for better financial management of clinical ... handout culture.// As per the new system that she is ... upon their capacity to attract patients. The first rulebook which ... which will seek to put an end to financial deficits. ...
... born woman will be cycling across the Indian state of ... of the women and children living in the state.// She ... November and 26 November 2006. Jayne Watson who is a ... ,Watson, from Guisborough in north England, hopes ...
... asthma if they are taught to swim before the age ... at Belgium's Catholic University of Louvain.// He also added that ... the air above indoor paddling pools than in adult pools, ... whom had been given swimming lessons before they reached the ...
... belonging to the Tulane University have come to the ... problems and the hardening of the arteries in the ... inflammation. //A test that is relatively inexpensive has been ... ,Inflammation occurs when the body responds in ...
... treatment of the fatal childhood cancer acute lymphoblastic leukemia ... according to researchers belonging to the St. Jude Children's ... the cure rate since 1962, when only 4% of ... more effective use of existing drugs and the incorporation ...
... new twist to the tale of bird(flu) the country in ... trying to// cover up the issues. ,They say ... the fight against a virus that has killed four Turkish ... Eker, “It is unofficially known that this illness exists in ...
Cached Medicine News:Health News:Children Face Risk While Swimming 2Health News:Acute Lymphoblastic Leukemia May Attain a 90% Cure Rate 2
(Date:10/1/2014)...   Plexus Information Systems, Inc. (Plexus ... Systems (AIMS), announced a partnership with NextGen ... subsidiary of Quality Systems, Inc. and a leading ... Logo - http://photos.prnewswire.com/prnh/20140930/149406 ... This partnership extends the NextGen Healthcare product portfolio ...
(Date:10/1/2014)... and NEW YORK , October 1, ... Research Organization (CRO) and service provider for the medical industries, announced ... of offices in New York City . genae ... City is strategically centered in one of the highest ... Coast", said Philippe Kassab , President at genae Americas. "The ...
(Date:10/1/2014)... 2014   Cypher Genomics, Inc., the genome ... Patrick Ravenel as chief technology officer. Ravenel has ... experience and a proven track record of designing and ... "Patrick has been recognized as a top designer and ... known industry-wide for delivering innovative products that operate at ...
Breaking Medicine Technology:Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 2Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 3genae Opens Offices in New York City 2Cypher Genomics Appoints J. Patrick Ravenel Chief Technology Officer 2
Diareader ELX800G...
EL301 Microwell Strip Reader is a portable, rugged, single/dual wavelength photometer designed to measure and interpret the absorbances of microwell strip assays....
Elisa strip reader...
... NRTL and CE certified microstrip ... automatic strip transportation. Easy to use ... printer. log-logit mode and other programming ... multi-point calibration curves, regressions, & a ...
Medicine Products: