Navigation Links
UT MD Anderson discovery wins 2010 Cozzarelli Prize
Date:2/23/2011

alth Science Center at Houston (UTHealth).

"The initial discovery by postdoctoral fellow Shengli Cai, Ph.D., Angela's first authorship and excellent collaboration with scientists at other institutions all made this a great project," Walker said.

The team discovered that ATM (short for Ataxia-Telangiectasia Mutated) recognizes damage caused by reactive oxygen species (ROS) in the cytoplasm and tells the cell to stop growing or orders the cell to consume itself, a process called autophagy.

Reactive oxygen species are a byproduct of cellular metabolism. They react with other molecules, are toxic in large amounts and kept in check by antioxidants. When that balance is disrupted, elevated ROS levels damage proteins, lipids and DNA.

Elevated ROS has been linked to more than 150 diseases, including diabetes, cancer, neurodegenerative diseases and atherosclerosis.

In its previously known role, ATM notices DNA damage, orders the cell to repair the damage and halts cell division. If repair is not possible, ATM sets off apoptosis - programmed cell death. ATM is commonly mutated in cancer.

ATM sets off a molecular chain of events to kill ROS-damaged cells that includes the tumor-suppressor TSC2, the protein originally targeted by the researchers.

One possibility raised by this research, Walker said, is the ability to activate ATM without damaging DNA.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0667
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Khalifa Foundation grants MD Anderson $150 million for cancer research
2. Peers elect MD Andersons Hung and Lozano as Fellows of AAAS
3. NIH award goes to UT MD Anderson imaging innovator Guerrero
4. MD Anderson study finds increases in 5-, 10-year survival at every stage of breast cancer
5. UT MD Anderson study finds women treated for breast cancer while pregnant have improved survival
6. MD Anderson keeps No. 1 cancer ranking in US News & World Report annual survey
7. Peg Fields to receive MD Andersons highest nurse-oncologist honor
8. Anderson & Kriger Takes Donations to Families Affected by Baja's Easter Earthquake
9. NACDS' Anderson Says Retailers and Suppliers' “Health and Wellness Renaissance” is Creating a “Historic, Watershed Moment”
10. M. D. Anderson receives 4.5 million grant, largest ever for study of yoga and cancer
11. M. D. Anderson zeroes in on better way to predict prognosis in pediatric leukemia patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT MD Anderson discovery wins 2010 Cozzarelli Prize
(Date:8/21/2014)... Inc. magazine ranked Centurion Service Group No. 3745 ... of the nation's fastest-growing private companies. The list represents ... of the economy—America’s independent entrepreneurs. Companies such as Yelp, ... other well-known names gained early exposure as members of ... been named to the Inc. 5000 list. We have ...
(Date:8/21/2014)... Sometimes you have to lose the life of ... “From Zero to a Hundred: Finding My Purpose through My Pain,” ... surviving a broken family, a childhood of gang violence and two ... were created to be,” Roy said. “I didn’t give up on ... my purpose today of helping others overcome their trials.” , He ...
(Date:8/21/2014)... NM (PRWEB) August 21, 2014 ... by the Centers for Disease Control and Prevention ... in assessing their compliance with the immunization standards ... and the CDC's General Recommendations on Immunizations. , ... of the many procedures in place to protect ...
(Date:8/21/2014)... August 21, 2014 InSilico ... interventions and addressing the challenges of a ... OncoFinder, for signalome-wide pathway analysis. This ... cross-platform analysis of gene expression data obtained ... published in the journal Frontiers in Molecular ...
(Date:8/20/2014)... August 21, 2014 Most people think ... summer months often get overlooked for a variety of ... for food pantries. Understanding this need, Dr. Bryne ... & natural health care center, wanted to heighten awareness ... hosted its first annual Thanksgiving in July food drive ...
Breaking Medicine News(10 mins):Health News:Centurion Service Group Named to Inc. Magazine's List of the Nation's Fastest-Growing Private Companies 2Health News:Centurion Service Group Named to Inc. Magazine's List of the Nation's Fastest-Growing Private Companies 3Health News:Centurion Service Group Named to Inc. Magazine's List of the Nation's Fastest-Growing Private Companies 4Health News:Zero to a Hundred: True Story of Escaping Death to Meet Life 2Health News:ACC Health Raises the Bar Again by Completing the CQIIP Certification Program 2Health News:OncoFinder, a new algorithm for minimizing errors in high-throughput transcriptome analysis 2Health News:AlignLife Springfield Office Donates 565 Canned Goods to Springfield Food Pantry 2
... The American College of Preventive Medicine (ACPM), a national ... physicians who administer individual and community immunization programs, has ... content of its program, Eli Stone, which suggests a ... The show is scheduled to air Thursday, January 31. ...
... AFL ) today reported its fourth quarter results., ... to the,dollar in the fourth quarter, rising 9.0% to ... of 2006. Net earnings were $382 million,or $.78 per ... share, a,year ago. Net earnings included realized investment losses ...
... for food, sex , , WEDNESDAY, Jan. 30 (HealthDay News) ... in drug addicts, even if they,re unaware that they,ve ... by the U.S. National Institute on Drug Abuse (NIDA). ... to monitor brain activity in cocaine-addicted patients while drug-related ...
... preserving Blue Cross,s nonprofit mission gives Michigan ... LANSING, Mich., Jan. 30 Creation of ... people rejected by,commercial insurers and HMOs because of ... the Michigan Senate Health Policy Committee,today. The Senate ...
... SYK ) announced today that it will participate in the ... - 2:20 p.m. Eastern Time 2008 ... Device Conference New York, New ... available,on Stryker,s website at http://www.stryker.com via the For Investors ...
... a pediatric neurologist at The Childrens Hospital of ... Medicine, has been named a Howard Hughes Medical ... 2007, Cheung was one of 15 physician-scientists selected ... Like all those chosen, Dr. Cheung focuses on ...
Cached Medicine News:Health News:Aflac Incorporated Announces Fourth Quarter Results 2Health News:Aflac Incorporated Announces Fourth Quarter Results 3Health News:Aflac Incorporated Announces Fourth Quarter Results 4Health News:Aflac Incorporated Announces Fourth Quarter Results 5Health News:Aflac Incorporated Announces Fourth Quarter Results 6Health News:Aflac Incorporated Announces Fourth Quarter Results 7Health News:Aflac Incorporated Announces Fourth Quarter Results 8Health News:Aflac Incorporated Announces Fourth Quarter Results 9Health News:Aflac Incorporated Announces Fourth Quarter Results 10Health News:Aflac Incorporated Announces Fourth Quarter Results 11Health News:Aflac Incorporated Announces Fourth Quarter Results 12Health News:Aflac Incorporated Announces Fourth Quarter Results 13Health News:Drug-Related Images Trigger Brain's Reward Center 2Health News:Blue Cross Blue Shield of Michigan Says Guaranteed Access Provisions of Insurance Reform Bills Protect Michigan Consumers Twice-Over 2Health News:Blue Cross Blue Shield of Michigan Says Guaranteed Access Provisions of Insurance Reform Bills Protect Michigan Consumers Twice-Over 3Health News:Stryker to Present at Investor Conference 2Health News:Genetics researcher at Children's Hospital selected as Howard Hughes Medical Institute Investigator 2
(Date:8/20/2014)... 20, 2014 Research and Markets ... "Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and ... report to their offering. A ... and geography) - Size, Share, Global Trends, Company ... and Forecast, 2013 - 2020", suggests that the ...
(Date:8/20/2014)... ALBANY, New York , August 20, 2014 /PRNewswire/ ... published a new market report titled "Monochloroacetic Acid (MCA) ... Other Applications - Global Industry Analysis, Size, Share, Growth, ... acid market was valued at USD 817.1 million in ... by 2020, growing at a CAGR of 3.6% during ...
(Date:8/20/2014)... Research and Markets has ... Wound Care and Closure Market (Types, Applications, End ... Company Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, ... to their offering. The new ... market (types, applications, end user and geography) - ...
Breaking Medicine Technology:Global Biosimilars/Follow-on-Biologics Market (Technology, Types, Applications, Services and Geography) - Research Report, 2013 - 2020 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 3Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 4Global Advanced Wound Care and Closure Market (Types, Applications, End User and Geography) - Forecast to 2020 2
... MINNETONKA, Minn. , July 14 American ... provider of world-class devices and therapies for both male and ... study on their market leading MiniArc Single-Incision Sling System for ... MiniArc efficacy rates for negative cough stress test (CST) and ...
... and TULSA, Okla. , July 14 ... strategic alliance to increase the availability of important new ... These tests and the GeneMedRx medication management software can ... personalize their prescribing practices in order to prevent adverse ...
Cached Medicine Technology:12-Month Study Reports 90% Success Rate for AMS' MiniArc Single-Incision Sling 212-Month Study Reports 90% Success Rate for AMS' MiniArc Single-Incision Sling 3Helix Bioscience Appointed DNA Drug Sensitivity Testing Distributor for Genelex Corporation 2
The Sutura family of products is designed to allow interventionalists to perform vessel closure from 6F up to 24F. It's elegant design allows one-handed use through sheath, routinely eliminating need...
The Closer vascular closure device is a suture mediated closure system. It has a sheath-like profile and easy positioning. It has an innovative design which involves the needles outside the artery an...
Spyglass angiography catheters, combined with St. Jude Medical hemostasis introducers and GuideRight guidewires, offer a safe and effective diagnostic angiography system....
Jography angiographic catheter has a new material combination, a patented angled weld, a flat wire braid design with a XXL lumen. It also has an atraumatic soft tip....
Medicine Products: