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UT MD Anderson discovery wins 2010 Cozzarelli Prize
Date:2/23/2011

HOUSTON - While studying one tumor-suppressing protein, Cheryl Walker's research team at The University of Texas MD Anderson Cancer Center came across a separate surprise. They found another protective protein known to work inside the cell nucleus moonlighting out in the cell's cytoplasm.

Following up on this unexpected observation, they discovered the cancer-blocking nuclear protein ATM has a second job controlling and killing damaged cells in the area between the nucleus and the cell membrane. Both functions stymie cancer by preventing reproduction of defective cells.

Their groundbreaking paper in the Proceedings of the National Academy of the Sciences has been chosen for the Cozzarelli Prize as the best paper in the Biological Science category published in the Proceedings during 2010. The prizes are given to the top paper in six categories out of more than 3,700 studies published by the journal each year.

"The Cozzarelli Prize is wonderful recognition of research that brought to light a brand new aspect of cell biology and marked a new direction for our lab," said Walker, a Ph.D. and professor in the Department of Molecular Carcinogenesis. The department is located at MD Anderson's Virginia Harris Cockrell Cancer Research Center, Science Park, near Smithville, Texas.

"Discovery of ATM's additional anti-tumor role is the type of basic science research that heightens our understanding of cancer and paves the way for improved prevention and treatment," said Raymond DuBois, M.D., Ph.D., MD Anderson provost and executive vice president. "The Cozzarelli Prize is a great honor for Cheryl, her lab and MD Anderson.

"The award also highlights the opportunities available for graduate students at MD Anderson," DuBois said. Co-first author Angela Alexander is a doctoral student in The University of Texas Graduate School of Biomedical Sciences, which is operated jointly by MD Anderson and The University of Texas He
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Contact: Scott Merville
smerville@mdanderson.org
713-792-0667
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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