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UT MD Anderson, Texas A&M team up to treat canine lymphoma
Date:2/7/2012

f cyclophosphamide, vincristine, doxorubicin and prednisone. The T cells were then given back intravenously after the chemotherapy to improve the anti-tumor effects.

"The therapy was well tolerated in all dogs who received the infusions. We saw fewer side effects than with traditional chemotherapy, and the pet owners were please with how their dogs tolerated the protocol," said Heather Wilson-Robles, DVM, DACVIM(Oncology), assistant professor at Texas A&M. "The owners were also very pleased to be supporting research that may further enhance cancer therapy in humans and pets with cancer."

"Treating dogs with cancer provides us with a great comparative oncology model for humans," said Colleen O'Connor, Ph.D., post-doctoral fellow at MD Anderson and one of the primary investigators on the study. "We learned important details about the interaction between chemotherapy and tumor cells that can be harnessed to improve the body's immune response. This is something we hadn't appreciated thus far from our clinical research in humans."

From the trial, investigators found that:

  • Chemotherapy, while damaging the canine tumor, also makes the tumor cells susceptible to recognition by the infused T cells
  • Infusing back the patient's T cells after chemotherapy can work to improve the survival of canines with NHL, since these T cells were held outside the body preventing damage from the chemotherapy
  • Biomarkers were identified that can potentially play a role in determining prognosis

Overall the study further affirmed the ability to use the body's own immune cells, such as T cells, to fight cancer. As a result, MD Anderson and Texas A&M collaborators are creating a program focusing on harvesting and expanding T cells at a large scale for broad clinical use.

Investigators at both institutions are working to open a new trial that will infuse genetically modified T cells that are tumor specific and potentially e
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Contact: Sara Farris
sfarris@mdanderson.org
713-792-9133
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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