Navigation Links
UT MD Anderson, Texas A&M team up to treat canine lymphoma
Date:2/7/2012

A new immunotherapy for companion dogs with advanced-stage non-Hodgkin lymphoma (NHL) has been shown to improve survival while maintaining quality of life, according to a study published in the journal Scientific Reports. The study resulted from a collaboration between The University of Texas MD Anderson Children's Cancer Hospital in Houston and Texas A&M University College of Veterinary Medicine in College Station.

Using a T-cell therapy developed at MD Anderson Children's Cancer Hospital, veterinarians from Texas A&M saw a nearly four-fold improvement in tumor-free survival compared to dogs who received only chemotherapy. The median tumor-free survival for the Texas-based dogs increased by close to nine months, which is roughly equivalent to seven years in a human life span.

NHL is one of the most common cancers in dogs, according to Texas A&M veterinarians. Although standard chemotherapy can achieve remission, it is rarely a curative treatment, with the two-year survival rate remaining less than 20 percent. When investigators from MD Anderson and Texas A&M met, they explored the feasibility of administering T cells to improve survival.

"We followed the same rigid standards that we practice for human clinical trials at MD Anderson to ensure the safety of each dog," said Laurence Cooper, M.D., Ph.D., professor and section chief of cell therapy at the children's hospital and senior investigator on the study. "While these pets are benefiting from the T-cell infusions, this collaboration with Texas A&M is a driving force for undertaking similar clinical trials in humans."

To accomplish the T-cell therapy, researchers took a sample of peripheral blood from each dog entering the study. Then the T cells were separated and expanded in Cooper's laboratory over several weeks. As the T cells grew at MD Anderson, the canines received a chemotherapy regimen at Texas A&M similar to what humans with NHL receive, a combination of cyclophosphamide, vincristine, doxorubicin and prednisone. The T cells were then given back intravenously after the chemotherapy to improve the anti-tumor effects.

"The therapy was well tolerated in all dogs who received the infusions. We saw fewer side effects than with traditional chemotherapy, and the pet owners were please with how their dogs tolerated the protocol," said Heather Wilson-Robles, DVM, DACVIM(Oncology), assistant professor at Texas A&M. "The owners were also very pleased to be supporting research that may further enhance cancer therapy in humans and pets with cancer."

"Treating dogs with cancer provides us with a great comparative oncology model for humans," said Colleen O'Connor, Ph.D., post-doctoral fellow at MD Anderson and one of the primary investigators on the study. "We learned important details about the interaction between chemotherapy and tumor cells that can be harnessed to improve the body's immune response. This is something we hadn't appreciated thus far from our clinical research in humans."

From the trial, investigators found that:

  • Chemotherapy, while damaging the canine tumor, also makes the tumor cells susceptible to recognition by the infused T cells
  • Infusing back the patient's T cells after chemotherapy can work to improve the survival of canines with NHL, since these T cells were held outside the body preventing damage from the chemotherapy
  • Biomarkers were identified that can potentially play a role in determining prognosis

Overall the study further affirmed the ability to use the body's own immune cells, such as T cells, to fight cancer. As a result, MD Anderson and Texas A&M collaborators are creating a program focusing on harvesting and expanding T cells at a large scale for broad clinical use.

Investigators at both institutions are working to open a new trial that will infuse genetically modified T cells that are tumor specific and potentially even more effective against the canine cancer cells.


'/>"/>

Contact: Sara Farris
sfarris@mdanderson.org
713-792-9133
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Research finds Medicare and private insurance spending similar throughout Texas
2. Scott & White Healthcare is 1 of 3 in Texas to receive workforce development grants
3. TB Outbreaks in Texas Schools Show Disease Still a Threat
4. 2 scientists at the University of Texas at Austin receive early career awards from White House
5. Internationally recognized BME professor to join University of Texas as visiting scholar
6. Drug recognition program available for Texas employers
7. Bad cholesterol not as bad as people think, shows Texas A&M study
8. Largest physics meeting of the year: March 20-25, 2011, Dallas, Texas
9. Wild Hogs in Texas Pose Infection Risk to Humans
10. Texas Center for Cancer Nanomedicine targets 2 tough cancers
11. Health IT program at the University of Texas at Austin receives $2.7 million in federal funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 ... , and OptiMed Specialty Pharmacy of Kalamazoo, ... offer a strategic hub service that expedites and streamlines ... personal spirometer, Spiro PD 2.0, and wellness management services.  ... is a medical device used to measure lung function ...
Breaking Medicine Technology: