Navigation Links
UT Arlington physicist's tool has potential for brain mapping
Date:5/16/2013

A new tool being developed by UT Arlington assistant professor of physics could help scientists map and track the interactions between neurons inside different areas of the brain.

The journal Optics Letters recently published a paper by Samarendra Mohanty on the development of a fiber-optic, two-photon, optogenetic stimulator and its use on human cells in a laboratory. The tiny tool builds on Mohanty's previous discovery that near-infrared light can be used to stimulate a light-sensitive protein introduced into living cells and neurons in the brain. This new method could show how different parts of the brain react when a linked area is stimulated.

The technology would be useful in the BRAIN mapping initiative recently championed by President Barack Obama, Mohanty said. BRAIN stands for Brain Research Through Advancing Innovative Neurotechnologies and will include $100 million in government investments in research.

"Scientists have spent a lot of time looking at the physical connections between different regions of the brain. But that information is not sufficient unless we examine how those connections function," Mohanty said. "That's where two-photon optogenetics comes into play. This is a tool not only to control the neuronal activity but to understand how the brain works."

The two-photon optogenetic stimulation described in the Optics Letter paper involves introducing the gene for ChR2, a protein that responds to light, into a sample of excitable cells. A fiber-optic infrared beam of light can then be used to precisely excite the neurons in a tissue circuit.

In the brain, researchers would then observe responses in the excited area as well as other parts of the neural circuit. In living subjects, scientists would also observe the behavioral outcome, Mohanty said.

Optogenetic stimulation avoids damage to living tissue by using light to stimulate neurons instead of electric pulses used in past research. Mohanty's method of using low-energy near-infrared light also enables more precision and a deeper focus than the blue or green light beams often used in optogenetic stimulation, the paper said.

Using fiber optics to deliver the two-photon optogenetic beam is another advance. Previous methods required bulky microscopes or complex scanning beams. Mohanty's group is collaborating with UT Arlington Department of Psychology assistant professor Linda Perrotti to apply this technology in living animals.

"Dr. Mohanty's innovations continue to be recognized because of the great potential they hold," said Pamela Jansma, dean of the UT Arlington College of Science. "Hopefully, his work will one day provide researchers in other fields the tools they need to examine how the human body works and why normal processes sometimes fail."


'/>"/>

Contact: Traci Peterson
tpeterso@uta.edu
817-272-9208
University of Texas at Arlington
Source:Eurekalert

Related medicine news :

1. Arlington Realtor VA "Best of the Best" Awarded to Gift Thongpia-Hughes for Excellence by Follow Media Consulting, Inc.
2. Arlington, VA Cosmetic Dentist, Dr. Duke Kim Now Offers Modern Alternatives to Traditional Braces with the Invisalign and Six Month Smiles Teeth Straightening Methods
3. Podiatrist in VA "Best of the Best" Awarded to Arlington Foot and Ankle for Excellence by Follow Media Consulting, Inc.
4. Yoga in Arlington VA 'Best of the Best' Awarded to Mind Your Body Oasis for Excellence by Follow Media Consulting, Inc.
5. Shimadzu Scientific Instruments donates record $7.5 million to UT Arlington
6. UT Arlington receives Grand Challenges Explorations grant for research in global health
7. Charge detector for ion chromatography co-developed by UT Arlington and Thermo Fisher Scientific
8. American Chemical Society to honor UT Arlington chemist
9. Nursing and social work students learning to work together at UT Arlington
10. Seeing is believing: Biologists and physicists produce revealing images of cell organization, behavior
11. Rottenstein Law Group LLP Responds to Study Linking Pradaxa Side Effects with Potential Mortality Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... TopConsumerReviews.com recently awarded ... Eyeglasses . , Millions of individuals in the United States and Canada wear ... a way to both correct vision and make a fashion statement. Even celebrities use ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... inhaled drugs, announced today that it was added to ... its comprehensive set of U.S. and global equity ... an important milestone for Pulmatrix," said Chief Executive Officer ... of our progress in developing drugs for crucial unmet ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
Breaking Medicine Technology: