Navigation Links
USF study finds stem cell combination therapy improves traumatic brain injury outcomes
Date:3/20/2014

Tampa, FL (Mar. 20, 2014) Traumatic brain injuries (TBI), sustained by close to 2 million Americans annually, including military personnel, are debilitating and devastating for patients and their families. Regardless of severity, those with TBI can suffer a range of motor, behavioral, intellectual and cognitive disabilities over the short or long term. Sadly, clinical treatments for TBI are few and largely ineffective.

In an effort to find an effective therapy, neuroscientists at the Center of Excellence for Aging and Brain Repair, Department of Neurosurgery in the USF Health Morsani College of Medicine, University of South Florida, have conducted several preclinical studies aimed at finding combination therapies to improve TBI outcomes.

In their study of several different therapiesalone and in combinationapplied to laboratory rats modeled with TBI, USF researchers found that a combination of human umbilical cord blood cells (hUBCs) and granulocyte colony stimulating factor (G-CSF), a growth factor, was more therapeutic than either administered alone, or each with saline, or saline alone.

The study appeared in a recent issue of PLoS ONE.

"Chronic TBI is typically associated with major secondary molecular injuries, including chronic neuroinflammation, which not only contribute to the death of neuronal cells in the central nervous system, but also impede any natural repair mechanism," said study lead author Cesar V. Borlongan, PhD, professor of neurosurgery and director of USF's Center of Excellence for Aging and Brain Repair. "In our study, we used hUBCs and G-CSF alone and in combination. In previous studies, hUBCs have been shown to suppress inflammation, and G-CSF is currently being investigated as a potential therapeutic agent for patients with stroke or Alzheimer's disease."

Their stand-alone effects have a therapeutic potential for TBI, based on results from previous studies. For example, G-CSF has shown an ability to mobilize stem cells from bone marrow and then infiltrate injured tissues, promoting self-repair of neural cells, while hUBCs have been shown to suppress inflammation and promote cell growth.

The involvement of the immune system in the central nervous system to either stimulate repair or enhance molecular damage has been recognized as key to the progression of many neurological disorders, including TBI, as well as in neurodegenerative diseases such as Parkinson's disease, multiple sclerosis and some autoimmune diseases, the researchers report. Increased expression of MHCII positive cellscell members that secrete a family of molecules mediating interactions between the immune system's white blood cellshas been directly linked to neurodegeneration and cognitive decline in TBI.

"Our results showed that the combined therapy of hUBCs and G-CSF significantly reduced the TBI-induced loss of neuronal cells in the hippocampus," said Borlongan. "Therapy with hUBCs and G-CSF alone or in combination produced beneficial results in animals with experimental TBI. G-CSF alone produced only short-lived benefits, while hUBCs alone afforded more robust and stable improvements. However, their combination offered the best motor improvement in the laboratory animals."

"This outcome may indicate that the stem cells had more widespread biological action than the drug therapy," said Paul R. Sanberg, distinguished professor at USF and principal investigator of the Department of Defense funded project. "Regardless, their combination had an apparent synergistic effect and resulted in the most effective amelioration of TBI-induced behavioral deficits."

The researchers concluded that additional studies of this combination therapy are warranted in order to better understand their modes of action. While this research focused on motor improvements, they suggested that future combination therapy research should also include analysis of cognitive improvement in the laboratory animals modeled with TBI.


'/>"/>
Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3303
University of South Florida (USF Innovation)
Source:Eurekalert

Related medicine news :

1. IU, Regenstrief study: New noninvasive colorectal cancer screening tool highly accurate
2. Sepsis study comparing 3 treatment methods shows same survival rate
3. Better continuity of care for elderly pataients cuts costs and complications, study finds
4. US headache sufferers get $1 billion worth of brain scans each year, U-M study finds
5. Patient requests for specific drugs have major impact on prescribing, reports study in Medical Care
6. Study proposes new ovarian cancer targets
7. MU study suggests new rehabilitation methods for amputees and stroke patients
8. Study: MLB pitchers dont regain performance level after Tommy John surgery
9. Claim that raw milk reduces lactose intolerance doesnt pass smell test, study finds
10. For older drivers, study finds, 1 drink may be 1 too many
11. Large-scale study shows power of pre-k
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... Arlington, Va. (PRWEB) , ... May 06, 2016 ... ... Foundation today announced a radio- and digital-based Zika education initiative in Puerto Rico. ... will encourage women to seek advice from physicians and pharmacists about ways to ...
(Date:5/6/2016)... ... May 06, 2016 , ... According to Florida ... they try to get rid of the bugs and keep them away. As ... out how to protect their kids and their homes from the parasite that will ...
(Date:5/6/2016)... ... May 06, 2016 , ... The Price ... created to support and assist the people of their local community. The agency ... organizations and community leaders. Their desire is to bring awareness to important local ...
(Date:5/6/2016)... ... May 06, 2016 , ... The joy associated with Mother’s Day is mixed with worry ... intensive care units (NICUs) across the country. For the first time ever, the March ... these women who spend their Mother’s Day beside a crib surrounded by lifesaving equipment or ...
(Date:5/6/2016)... ... May 06, 2016 , ... US Sports Camps has ... camp held at Oregon State University this summer. Employing world-class rugby figures, including former ... all skill levels with training on key fundamentals, match play, fitness and more. , ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... DUBLIN, May 5, 2016 , First ... and revenues of $964 million , First ... of $0.40 , Company revises 2016 financial ... to $4.03 billion and 2016 adjusted diluted non-GAAP earnings per ... Company provides updates regarding Generics business and manufacturing facility ...
(Date:5/5/2016)... 2016 Research and Markets has announced the ... 5 EU Markets"  report to their offering.  ,     (Logo: ... on the current Positron Emission Tomography (PET) scanner and cyclotron ... which includes France , Germany ... and the United Kingdom . ...
(Date:5/5/2016)... May 5, 2016 ... the  "Europe Systemic Lupus Erythematosus Market and ... their offering.       (Logo: ... research Europe Systemic Lupus Erythematosus Market and ... insights into Systemic Lupus Erythematosus pipeline products, ...
Breaking Medicine Technology: