Navigation Links
USF receives patent for technology to improve treatment for neurodegenerative diseases

Tampa, FL (July 8, 2010) The University of South Florida's Department of Neurosurgery and Brain Repair has been granted a patent for a cell transplantation procedure combining human umbilical cord blood (HUCB) cells and a sugar-alcohol compound called "mannitol" that may make a big difference in treating life-threatening neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and stroke, among others.

The technology administers the neuroprotective effect of umbilical cord blood cells along with mannitol to permeabilize the blood-brain barrier, allowing for the increased entry of therapeutic growth factors. Saneron CCEL Therapeutics, Inc., a biotechnology R&D USF spin-out company located at the Tampa Bay Technology Incubator, has licensed the technology.

"Approximately 750,000 strokes occur every year in the United States, and nearly one third of them are fatal," said Saneron's President and COO, Nicole Kuzmin-Nichols, MBA. "Given the devastating effects of stroke, it is imperative that we develop new therapies to minimize damage to the brain as well as repair the damage. We are excited about this new technology and its potential to help us develop a variety of new products and therapies to do just that."

While transplanted HUCB cells may benefit several neurological diseases, getting them past the blood-brain-barrier has presented a problem. The blood-brain barrier separates circulating blood and cerebral spinal fluid in the central nervous system. The newly patented technology is based on mannitol acting as a blood-brain barrier permeabilizer to help get the therapeutic substances secreted by HUCB cells past the blood-brain barrier and into the central nervous system. Mannitol, which temporarily shrinks the tight cells that make up the barrier, allows HUCB cells, via their secreted factors, to reach the site of injury or disease.

"Human umbilical cord blood contains a high percentage of stem cells that when intravenously administered can survive and differentiate into neurons in the damaged brain. Equally appealing is their ability to secrete beneficial molecules that potentially promote behavioral recovery," said Dr. Cesar Borlongan, co-inventor and a USF neuroscientist and professor and consultant for Saneron. "Because the blood-brain barrier regulates the entry of many blood-borne substances into the brain, it may exclude potentially therapeutic substances."

"The use of stem cell therapy as a treatment for neurodegenerative disorders shows exciting promise, though several hurdles must be overcome and getting the cells correctly positioned is one of those," said Nicole Kuzmin-Nichols. "This technology provides the means to deliver the HUCB cells directly to the damaged brain to maximize their effect."


Contact: Randolph Fillmore
University of South Florida (USF Health)

Related medicine news :

1. Quincy Bioscience Receives Patent for Jellyfish Protein Aequorin
2. Childrens Hospital Los Angeles oncologist receives $50,000 Hyundai Scholar Award
3. Stamen Medical Systems Receives Medicare Re-Accreditation and The Exemplary Provider Award
4. BIDMC researcher receives Young Investigator Award from Prostate Cancer Foundation
5. Datatel's Hosted Pay-by-Phone Credit Card Payment IVR Gateway Receives Heartland Payment Systems Certification
6. UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital
7. A*STAR scientist receives international award for innovation in healthcare technology
8. NYUs Movshon receives Champalimaud Vision Award for work on how brain reconstructs images
9. Sung-Cheng (Henry) Huang receives 2010 Benedict Cassen Prize for Research in Nuclear Medicine
10. Chester A. Mathis receives SNMs 2010 Aebersold Award
11. Bengt Roland Långström receives SNMs 2010 Georg Charles de Hevesy Nuclear Pioneer Award
Post Your Comments:
(Date:11/30/2015)... DE (PRWEB) , ... November 30, 2015 , ... ... guest lecturer at a University of Delaware Accounting and Management of Information Systems ... software solutions for mid-market businesses. Sommer will speak at before student in the ...
(Date:11/30/2015)... ... November 30, 2015 , ... Cycling, running, and walking are regular Sunday activities ... morning of February 28, 2016. , That’s when the 7th annual ANF Group ... to help children and families at Joe DiMaggio Children’s Hospital. , The ...
(Date:11/30/2015)... ... November 30, 2015 , ... HemoTreat™ has announced that the ... ointment to its website. , “Our goal is simple:” says Michael Blasco, HemoTreat’s ... the comparison chart and ingredient list allows our customers to quickly see why, ...
(Date:11/30/2015)... ... , ... At Grand Dental PC, their priority is to deliver quality care ... problems, you need to turn to a dentist who listens and responds; an experienced ... friendly dentist who counsels you on the best ways to maintain and improve your ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... Dr. Seth ... three office locations, patients can visit Dr. Margulies to experience the best available orthodontic ... hold the title of "NJ Top Dentist"! , Orthodontics is the branch of dentistry ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , November 30, 2015 North America ... is expected to grow at a CAGR of 7.6% from 2015 ... valued at USD 135.6 million in 2014, and is expected to ... --> According to the new Market Research Report "North America ... By End User (Hospitals, ambulatory care, others) - Analysis And Forecast ...
(Date:11/30/2015)... , November 30, 2015 /PRNewswire/ ... --> adds a ... for 2010 - 2015 with comprehensive ... a range of deal types, such ... strategic alliances. ...
(Date:11/30/2015)... Nov. 30, 2015  Kevin Smith has been ... a global pioneer in wireless monitoring of vital ... MA , Mr. Smith will be responsible ... commercial strategy.  He will also directly oversee partnering ... clinical evidence for SensiumVitals, the first early warning ...
Breaking Medicine Technology: