Navigation Links
USF receives patent for technology to improve treatment for neurodegenerative diseases
Date:7/8/2010

Tampa, FL (July 8, 2010) The University of South Florida's Department of Neurosurgery and Brain Repair has been granted a patent for a cell transplantation procedure combining human umbilical cord blood (HUCB) cells and a sugar-alcohol compound called "mannitol" that may make a big difference in treating life-threatening neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and stroke, among others.

The technology administers the neuroprotective effect of umbilical cord blood cells along with mannitol to permeabilize the blood-brain barrier, allowing for the increased entry of therapeutic growth factors. Saneron CCEL Therapeutics, Inc., a biotechnology R&D USF spin-out company located at the Tampa Bay Technology Incubator, has licensed the technology.

"Approximately 750,000 strokes occur every year in the United States, and nearly one third of them are fatal," said Saneron's President and COO, Nicole Kuzmin-Nichols, MBA. "Given the devastating effects of stroke, it is imperative that we develop new therapies to minimize damage to the brain as well as repair the damage. We are excited about this new technology and its potential to help us develop a variety of new products and therapies to do just that."

While transplanted HUCB cells may benefit several neurological diseases, getting them past the blood-brain-barrier has presented a problem. The blood-brain barrier separates circulating blood and cerebral spinal fluid in the central nervous system. The newly patented technology is based on mannitol acting as a blood-brain barrier permeabilizer to help get the therapeutic substances secreted by HUCB cells past the blood-brain barrier and into the central nervous system. Mannitol, which temporarily shrinks the tight cells that make up the barrier, allows HUCB cells, via their secreted factors, to reach the site of injury or disease.

"Human umbilical cord blood contains a high percentage of stem cells that when intravenously administered can survive and differentiate into neurons in the damaged brain. Equally appealing is their ability to secrete beneficial molecules that potentially promote behavioral recovery," said Dr. Cesar Borlongan, co-inventor and a USF neuroscientist and professor and consultant for Saneron. "Because the blood-brain barrier regulates the entry of many blood-borne substances into the brain, it may exclude potentially therapeutic substances."

"The use of stem cell therapy as a treatment for neurodegenerative disorders shows exciting promise, though several hurdles must be overcome and getting the cells correctly positioned is one of those," said Nicole Kuzmin-Nichols. "This technology provides the means to deliver the HUCB cells directly to the damaged brain to maximize their effect."


'/>"/>

Contact: Randolph Fillmore
rfillmor@health.usf.edu
813-974-0868
University of South Florida (USF Health)
Source:Eurekalert

Related medicine news :

1. Quincy Bioscience Receives Patent for Jellyfish Protein Aequorin
2. Childrens Hospital Los Angeles oncologist receives $50,000 Hyundai Scholar Award
3. Stamen Medical Systems Receives Medicare Re-Accreditation and The Exemplary Provider Award
4. BIDMC researcher receives Young Investigator Award from Prostate Cancer Foundation
5. Datatel's Hosted Pay-by-Phone Credit Card Payment IVR Gateway Receives Heartland Payment Systems Certification
6. UCSF Children's Hospital Receives $100 Million Gift To Build New Hospital
7. A*STAR scientist receives international award for innovation in healthcare technology
8. NYUs Movshon receives Champalimaud Vision Award for work on how brain reconstructs images
9. Sung-Cheng (Henry) Huang receives 2010 Benedict Cassen Prize for Research in Nuclear Medicine
10. Chester A. Mathis receives SNMs 2010 Aebersold Award
11. Bengt Roland Långström receives SNMs 2010 Georg Charles de Hevesy Nuclear Pioneer Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... 2016 , ... Francesca Loparco, Co-Founder of Queen City Dream Cars, an exotic ... LASIK procedure at Christenbury Eye Center. The entrepreneur struggled with her computer, riding ... same day as her in-office consultation and eye exam. Francesca’s eyesight was restored to ...
(Date:5/4/2016)... ... 2016 , ... Natalie Jill is a well respected lifestyle mentor ... the launch of her new book: Natalie Jill’s 7 Day Jump Start: Unprocess Your ... jump start a new healthy lifestyle featuring simple recipes using MitoXcell’s raw cacao formula. ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... pharmacy industry, today announced that it was chosen as the Pharmaceutical News Provider ... Awards . The awards acknowledge the hard work and dedication of community members ...
(Date:5/4/2016)... ... May 04, 2016 , ... The preeminent surgical aftercare facility Pearl ... following breast cancer surgery. In March 2016, the 61-year-old model and reality TV star ... that occurs in the milk ducts, according to an interview with the Daily ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... multi-function small and compact tactical (6.7 inch) dual-light flashlights in models NSP-9842XL ... model NSP-9842XL (average retail starting at $59.95) uses 2 included CR-123 batteries to ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... May 2, 2016 Kalorama Information noted the ... Records) market in a recent white paper.  The healthcare ... physician usage, a growing market are among the top ... Kalorama,s report EMR 2016: The Market for ... seventh complete study of the EMR industry, and the ...
(Date:5/2/2016)... N.J. , May 2, 2016  Celsion ... development company, today announced data from the first ... escalating clinical trial (the OVATION Study) combining GEN-1, ... care for the treatment of newly-diagnosed patients with ... followed by interval debulking surgery.  In the first ...
(Date:4/29/2016)... , April 29, 2016 ... Life Sciences, Product Development Capabilities in ... Customer Base . Indegene ( ... announced the acquisition of Skura Corporation,s life science ... in adaptive sales enablement technology for life science ...
Breaking Medicine Technology: