Navigation Links
USF and Saneron get $2.6 million to develop Alzheimer's treatment using umbilical cord blood cells
Date:10/5/2010

The National Institutes of Health has awarded a three-year, $2.6-million grant to the University of South Florida and Tampa-based biotechnology company Saneron-CCEL Therapeutics, Inc., to establish dosing and safety guidelines for transplanting human umbilical cord blood cells (HUBC) into animal models of Alzheimer's disease. The researchers hope to use the pre-clinical data to gain U.S. Food and Drug Administration approval to carry out clinical trials with patients suffering from Alzheimer's disease.

"Our immediate goal is to move our beneficial findings with cord blood cells into clinical trials for patients with mild to moderate Alzheimer's disease," said the grant's principal investigator Dr. Jun Tan, a USF neuroscientist and professor of psychiatry.

The NIH Phase II Small Business Technology Transfer grant is based on the success of an ongoing research partnership between USF and Saneron aimed at determining the therapeutic benefits HUBCs offer when transplanted into animal models of a variety of neurological diseases, including Parkinson's disease, Lou Gehrig's disease (ALS), Alzheimer's disease and stroke.

"Our next stage of research is translational. This study's primary aims are the completion of preclinical safety and validation studies and the submission of an Investigational New Drug application to the FDA for a Phase I clinical trial," said Nicole Kuzmin-Nichols, president and chief operating officer of Saneron. "Saneron is very pleased and excited that our long-standing research partnership with USF has provided this opportunity to further the commercialization of technology that was developed at USF and transferred to Saneron for further development."

Additional funding will be provided by a Florida High Tech Corridor Industry Matching Grant through USF Connect.

Previous research by USF and Saneron has shown that injecting HUBC into laboratory (in vitro) and animal models (in vivo) of neurodegenerative diseases does not promote a strong immune response, so rejection is not a problem, Dr. Tan said. The potential for HUBCs to promote an anti-inflammatory response may provide overall benefits. Inflammation is a biochemical component of Alzheimer's disease.

Saneron CCEL Therapeutics, Inc. worked with USF to develop a HUBC cell technology platform called the U-CORD-CELL program. The program aims to improve the quality of life for patients by developing and producing innovative, high-quality treatments for neurological and cardiac diseases.

"This grant will afford Saneron the opportunity to bring the U-CORD-CELL technology to the clinic in the pursuit of a potential therapy for those suffering from Alzheimer's disease," Kuzmin-Nichols said.

According to USF senior vice president for research and innovation, Karen Holbrook, PhD, this collaborative work between USF and Saneron is the "essence of technology transfer."

"The best outcome for this kind of collaboration is when technology developed at the university is taken to the patient's bedside," said Dr. Holbrook. "USF is happy and proud to be working with Saneron on this most important research."


'/>"/>

Contact: Randolph Fillmore
rfillmor@health.usf.edu
813-974-0868
University of South Florida (USF Health)
Source:Eurekalert

Related medicine news :

1. Amway One by One Campaign for Children Reaches 7 Million Kids
2. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
3. International Diabetes Federation awards $2 million to 9 global diabetes research projects
4. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
7. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
8. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
9. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
10. Kaiser Permanente Approves $170 Million in Community Benefit Grants in 2009
11. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and ... 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will ... Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph ...
(Date:10/12/2017)... ... 12, 2017 , ... In the United States, single-family home ... states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is ... low property-tax rates, which contributes to the relatively lower cost of living in ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... ... Cal Dining at the University of California Berkeley, and other leading institutions in ... the buying power of institutions to change the way animals are raised for ...
(Date:10/12/2017)... Texas (PRWEB) , ... October 12, 2017 , ... ... and biologics manufacturer, has expanded its executive staff with the addition of industry ... In this role, Slott will develop the national distribution and sales network, direct ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical ... the company with their  2017 New Product Innovation Award ... on extensive primary and secondary medical device market research by ... through its first-to-market OTC, drug-free pain relief product, the AVACEN ... approach to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
Breaking Medicine Technology: