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USC study finds that green tea blocks benefits of cancer drug
Date:2/3/2009

study to be applicable to cancer patients.

"The most immediate conclusion from our study is the strong advice that patients undergoing cancer therapy with Velcade must avoid green tea, and in particular all of its concentrated products that are freely available from health food stores," says Schnthal. "It is important to spread this message to health care providers who administer Velcade to patients."

Schnthal points out that for patients on Velcade, supplementing with green tea products should reduce the burden of harsh side effectswhich might be attractive to the patient, but comes at a high cost.

"Essentially, in addition to not being able to attack tumor cells, Velcade would be unable to cause side effects either," he says. "As a result, the patient would feel a lot better and conclude that the consumption of GTE helped cope with side effectswhile in reality, Velcade simply wasn't active in the first place."

The research findings are part of a larger project run by the team called "Yin-Yang Properties of Green Tea Extract in Combination Cancer Chemotherapy: From Encouragingly Beneficial to Dangerously Detrimental."

"Obviously, the combination of GTE or EGCG with Velcade is an example of 'dangerously detrimental,' "Schnthal says. "But we are also studying another well-established chemotherapeutic drug, where the inclusion of EGCG appears to yield an 'encouragingly beneficial' outcome, which is more in line with our original expectation that GTE should be beneficial, not detrimental."


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Contact: Meghan Lewit
lewit@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

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