Navigation Links
USC study finds sex, age and ethnicity assciated with colorectal cancer survival
Date:5/29/2008

Chicago, Ill.--The interaction of sex, age and ethnicity has a significant impact on overall survival in metastatic colorectal cancer (MCRC) patients, a study led by researchers at the University of Southern California (USC) and USC/Norris Comprehensive Cancer Center suggests.

While age and ethnicity are well-established factors that impact survival in colorectal cancer, the study found that gender also plays an important role in overall survival, says Andrew Hendifar, M.D., MPH, fellow in the division of hematology/oncology at the Keck School of Medicine of USC and lead author of the study. Researchers found that pre-menopausal women with metastatic colorectal cancer (18-44 years old) lived longer than younger men, while older women (75 and older) had significantly worse overall survival than older men.

The results of the study will be presented at a poster discussion Sunday, June 1, at the 2008 annual meeting of the American Society of Clinical Oncology (ASCO) held at McCormick Place in Chicago.

The study adds to the growing evidence that female hormones are protective for colon cancer, researchers say.

"This study provides further evidence that estrogen may play an important role not only in colon cancer development but also progression of the disease, and may impact how we develop therapies for women and men with colon cancer," says Heinz-Josef Lenz, M.D., professor of medicine at the Keck School of Medicine and a senior investigator on the study.

Researchers screened 56,598 patients with metastatic colorectal cancer from 1988 to 2003, using the Surveillance, Epidemiology and End Results (SEER) registry. Models were created using the patients' age at diagnosis, sex, ethnicity and overall survival. Independent of age, there were no survival differences between men and women with MCRC. However, when age was added to the model, sex became significantly associated with survival across all ethnicities.

Researchers also found that certain ethnicities had better overall survival than others. Namely, Hispanics and Asians have better outcomes than Caucasians and African-Americans. Further studies in this area should look at how certain diets or specific surroundings contribute to the development of colorectal cancer, Hendifar notes.

"The data warrant further studies to determine the role of estrogen and ethnicity in colorectal cancer development," he says. "In the future, we may tailor different treatments for men and women."


'/>"/>

Contact: Meghan Lewit
lewit@usc.edu
323-442-3576
University of Southern California
Source:Eurekalert

Related medicine news :

1. Montana Center for Work Physiology and Exercise Metabolism presents firefighter health study
2. Moonview Sanctuary Releases First Case Study of Client Treated Using Unique Moonview Model
3. Montana Center for Work Physiology and Exercise Metabolism Presents Firefighter Health Study
4. Establishing a Price for Carbon Emissions in the U.S. Would Spur Immediate Reductions in Energy Consumption and More Efficient Use of Power Generators, Study by Carnegie Mellon Researchers Shows
5. Study IDs Gene for Late-Onset Alzheimers
6. Study: Child maltreatment victims lose 2 years of quality of life
7. New study shows sedentary high school girls are at significant risk for future osteoporosis
8. $1.3M NIH grant to fund Parkinsons disease study
9. New vaccine approach prevents/reverses diabetes in lab study at Childrens Hospital of Pittsburgh
10. New Study of Bush Medicare Cuts: Texas Rural Seniors, Nursing Homes 2nd Hardest Hit in Nation
11. Research Study Shows That Pharmaceutical Field Sales Reps Productivity Inhibited by Unnecessary Internal Communication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... 26, 2017 , ... New patients with missing teeth in Fitchburg, ... a referral. Dr. Cotey is a trusted dentist who has placed many dental implants ... Patients with missing teeth in Fitchburg, WI, are encouraged to find out if they ...
(Date:6/25/2017)... ... June 24, 2017 , ... Create a feel-good lyric music video in Final Cut Pro X ... the timeline and write in the lyrics to any song. ProLyric flies in the text ... of the text can be added modularly for optimal control. ProLyric makes editing any music ...
(Date:6/25/2017)... ... 25, 2017 , ... An increase in wetter weather in the Northern California ... with that; a humdinger of an allergy season. A relief from drought conditions is ... misery-causing grass and weed pollen. , “Our patients have been reporting the typical ...
(Date:6/25/2017)... ... ... With a heatwave currently bearing down on Northern California pushing temperatures to the maximum, many ... is easy with laser hair removal. , The process of summer waxing and constantly ... all you want to do is get out, dive in and cool off. There is ...
(Date:6/24/2017)... , ... June 24, 2017 , ... ... offering genetic testing for medications in select Florida and Texas doctors' offices and ... , This new application of genetic testing recognizes the role genes play in ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... Fla. , June 8, 2017  Less than ... that hit more than 200,000 companies, including hospital networks, ... being heralded as one of the largest online extortion ... in the healthcare market, it is imperative that providers ... protect their data from this — and many other ...
(Date:6/7/2017)... June 7, 2017 Endo International plc (NASDAQ: ... 2017, the Hon. Joseph R. Goodwin , U.S. ... West Virginia , entered a case management ... Repair System Products Liability Litigation (the "MDL") that includes ... to provide expert disclosures on specific causation within one ...
(Date:6/5/2017)... 2017 The Cincinnati location ... Inc. (NYSE: DPLO), has been awarded a Top Workplaces ... Results are based on an employee survey administered by ... workplace improvement. The survey measures several aspects of workplace culture, ... ...
Breaking Medicine Technology: