Navigation Links
USC study finds sex, age and ethnicity assciated with colorectal cancer survival
Date:5/29/2008

Chicago, Ill.--The interaction of sex, age and ethnicity has a significant impact on overall survival in metastatic colorectal cancer (MCRC) patients, a study led by researchers at the University of Southern California (USC) and USC/Norris Comprehensive Cancer Center suggests.

While age and ethnicity are well-established factors that impact survival in colorectal cancer, the study found that gender also plays an important role in overall survival, says Andrew Hendifar, M.D., MPH, fellow in the division of hematology/oncology at the Keck School of Medicine of USC and lead author of the study. Researchers found that pre-menopausal women with metastatic colorectal cancer (18-44 years old) lived longer than younger men, while older women (75 and older) had significantly worse overall survival than older men.

The results of the study will be presented at a poster discussion Sunday, June 1, at the 2008 annual meeting of the American Society of Clinical Oncology (ASCO) held at McCormick Place in Chicago.

The study adds to the growing evidence that female hormones are protective for colon cancer, researchers say.

"This study provides further evidence that estrogen may play an important role not only in colon cancer development but also progression of the disease, and may impact how we develop therapies for women and men with colon cancer," says Heinz-Josef Lenz, M.D., professor of medicine at the Keck School of Medicine and a senior investigator on the study.

Researchers screened 56,598 patients with metastatic colorectal cancer from 1988 to 2003, using the Surveillance, Epidemiology and End Results (SEER) registry. Models were created using the patients' age at diagnosis, sex, ethnicity and overall survival. Independent of age, there were no survival differences between men and women with MCRC. However, when age was added to the model, sex became significantly associated with survival across all ethnicities.

Researchers also found that certain ethnicities had better overall survival than others. Namely, Hispanics and Asians have better outcomes than Caucasians and African-Americans. Further studies in this area should look at how certain diets or specific surroundings contribute to the development of colorectal cancer, Hendifar notes.

"The data warrant further studies to determine the role of estrogen and ethnicity in colorectal cancer development," he says. "In the future, we may tailor different treatments for men and women."


'/>"/>

Contact: Meghan Lewit
lewit@usc.edu
323-442-3576
University of Southern California
Source:Eurekalert

Related medicine news :

1. Montana Center for Work Physiology and Exercise Metabolism presents firefighter health study
2. Moonview Sanctuary Releases First Case Study of Client Treated Using Unique Moonview Model
3. Montana Center for Work Physiology and Exercise Metabolism Presents Firefighter Health Study
4. Establishing a Price for Carbon Emissions in the U.S. Would Spur Immediate Reductions in Energy Consumption and More Efficient Use of Power Generators, Study by Carnegie Mellon Researchers Shows
5. Study IDs Gene for Late-Onset Alzheimers
6. Study: Child maltreatment victims lose 2 years of quality of life
7. New study shows sedentary high school girls are at significant risk for future osteoporosis
8. $1.3M NIH grant to fund Parkinsons disease study
9. New vaccine approach prevents/reverses diabetes in lab study at Childrens Hospital of Pittsburgh
10. New Study of Bush Medicare Cuts: Texas Rural Seniors, Nursing Homes 2nd Hardest Hit in Nation
11. Research Study Shows That Pharmaceutical Field Sales Reps Productivity Inhibited by Unnecessary Internal Communication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2017)... ... May 19, 2017 , ... The Hill Agencies, a family managed ... throughout the California Central Valley, is announcing a joint charity initiative with the Boys ... a local kid’s camp event. , The Boys and Girls Club of Kern County ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Arnold and Mabel Beckman ... Victor Acosta, Ph.D. - University of New Mexico, Jeremy Baskin, Ph.D. - Cornell ... Washington, Erik Grumstrup, Ph.D. - Montana Stata University, A. Fatih Sarioglu, Ph.D. - ...
(Date:5/19/2017)... ... May 19, 2017 , ... As a groundbreaking surgeon ... the importance of prostate cancer screenings. Early detection of the disease, he says, can ... surgery at Georgia Urology , stands alongside the Georgia Comprehensive Cancer Control’s (GC3) ...
(Date:5/19/2017)... (PRWEB) , ... May 18, 2017 , ... CloSYS products ... for being non-irritating while extremely helpful for mouth and gum health, which is linked ... their professionals and customers learned quickly of the powerful ways in which CloSYS products ...
(Date:5/19/2017)... Santa Clara, CA (PRWEB) , ... May 18, 2017 , ... ... feature that allows sleep labs and physicians to independently dispense CPAP devices and supplies, ... DME orders, and sleep labs can dispense the devices. Device registration for daily usage ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... BURNIE, Md. , May 10, 2017 ... retention solutions for the clinical research industry, is proud ... www.CSSiEnroll.com . The new website features both enriched ... overall user experience and enhances the company,s already well-established ... the industry. "After many months of ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its commitment ... of directors for the Pharmaceutical Research and Manufacturers ... membership. Biopharmaceutical companies will now have to meet ... to be eligible to join PhRMA. ... board is sending a clear message that being ...
(Date:5/9/2017)... , May 9, 2017  Semler Scientific, ... provides technology solutions to improve the clinical effectiveness ... results for the first quarter ended March 31, ... products enable our customers to identify when preventive ... intervene before events like heart attacks or strokes ...
Breaking Medicine Technology: