USC researchers identify novel approach for suppressing prostate cancer d...(he role of GRP78 in other types of cance...),Health

Date:11/24/2008

he role of GRP78 in other types of cancer and isolate drugs that inhibit GRP78, Lee says. "To our knowledge, this is the first demonstration that inactivation of a specific molecular chaperone from the mouse prostate epithelial cells can potently block prostate cancer development and suppress the activation of AKT, which is a protein kinase that promotes cell proliferation and survival and is a major factor in many types of cancer," Lee says. "With the recent advances in identifying agents that suppress GRP78 expression, anti-GRP78 therapy may open up an entirely new approach to stop human cancer."

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Contact: Meghan Lewit lewit@usc.edu 323-442-3941 University of Southern California Source:Eurekalert

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