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USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma
Date:6/12/2009

eins in which the wrong chromosome is wrapped (called chromatin) lures the RAG complex to the wrong site.

"The immune system is very good at its job," Lieber says. "More than ninety-nine percent of the time it gets it right, but it only takes one mistake in one of a hundred million cells to cause a problem. "

The paper follows a similar study, published in the December issue of the journal Cell, in which Lieber and colleagues determined how the most common chromosomal translocation in B cell lymphoma occurs. Researchers at USC have been working for many years to understand the underlying mechanisms that cause blood cancers.

"The goal is to understand translocations in various different forms of lymphoma," Lieber says. "The two papers cover more than half of all human lymphomas. That represents a major step forward in understanding this disease."


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Contact: Meghan Lewit
lewit@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

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