Navigation Links
USC researchers find new clues to risk of Hodgkin lymphoma
Date:4/1/2008

A long-term study of twins has led University of Southern California (USC) researchers to find potential links between Hodgkin lymphoma and levels of an immune response protein (interleukin-12).

"We found that lower levels of the protein interleukin-12, involved in fighting intracellular infections, increases susceptibility to young adult Hodgkin lymphoma," says Wendy Cozen, D.O., M.P.H, associate professor of preventive medicine at the Keck School of Medicine of USC. " Cozen is lead author on the study entitled, "Interleukin-2, interleukin-12, and interferon- levels and risk of young adult Hodgkin lymphoma," published in the April 1 issue of the journal, Blood.

The study is accompanied by an editorial entitled "Hodgkin twins: double good, double trouble," by Richard F. Ambinder of the Johns Hopkins School of Medicine.

The work is based on patient populations found in the International Twin Study and California Twin Program, unique registries of twin pairs developed and maintained in the Department of Preventive Medicine at USC.

Hodgkin lymphoma is the most common type of cancer among young women and the second most common type among young men. But while the 5-year survival rate is high compared to that of other cancers, the treatment may cause complications later in life.

According to Cozen, this study, along with a previous one her group published in 2007, provides the first clear evidence that individual differences in immune response (via cytokine secretion) may lead to the development of Hodgkin lymphoma.

"We previously showed that there is a substantial genetic risk for adolescent and young adult Hodgkin lymphoma, and that another immune response protein (interleukin-6) was related to risk," says Cozen. "We are pursuing the hypothesis that variations in genes control the secretion of these immune response proteins (cytokines) predicting Hodgkin lymphoma risk."

Eventually, based on the group's current work, researchers may be able to develop novel treatments to correct the abnormal immune response thereby offering alternatives to current therapy.

Cozen and her group are conducting an expanded study among adolescent and young adult Hodgkin lymphoma patients and their parents in Los Angeles.

The group is studying these genes and others that control the immune response in hopes of confirming their previous results and to further define the inherited patterns that explain the genetic part of the risk.

Cozen adds that colleagues from the National Cancer Institute and Washington University in St. Louis, will also be studying early exposures to infectious agents such as bacteria and viruses, which may interact with the immune system leading to Hodgkin lymphoma.


'/>"/>

Contact: Jennifer Chan
chanj@usc.edu
323-442-2830
University of Southern California
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... 20, 2017 , ... MRI screening improves early diagnosis of breast cancer in ... online in the journal Radiology . , MRI has long been known ... ultrasound. Currently, guidelines reserve breast MRI screening for women who have a strong family ...
(Date:2/20/2017)... ... , ... Scrubbing in for his first esophageal cancer case in the late ... of the surgeon training him. , “He was giddy and almost couldn’t contain himself ... but I would do it for free,’” Dr. Pezzi recalled. “He genuinely was so ...
(Date:2/20/2017)... ... , ... The StayWell Company and VUCA Health announced ... risks, foster behavior change and improve health literacy among patients. VUCA Health, which created ... of its video capability at StayWell booth 3443 during HiMSS. , The VUCA ...
(Date:2/20/2017)... ... ... Population Health Software Company, is pleased to announce a move to a larger office building ... size of the previous location while bringing life back to a medical practice building that ... excited to expand our footprint to better serve our growing client base. We are ...
(Date:2/20/2017)... ... February 20, 2017 , ... Today, Illuma Care Connections, a ... during the 2017 Annual HIMSS Conference & Exhibition in Orlando, Florida, ... and integrating eye care into mainstream healthcare delivery is powered by Secure ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Feb. 21, 2017  /PR Newswire/ -- UBM Medica,s ... announce the launch of Modern Retina ( ... retina specialists. Built upon the success of ... on the latest innovations in the areas of retinal ... management. By meeting current informational needs and filling existing ...
(Date:2/21/2017)... , Feb. 21, 2017   BeyondSpring ... on the development of innovative immuno-oncology cancer therapies, ... significant data from its Phase 2 trial of ... the treatment of non-small cell lung cancer (NSCLC) ... at this year,s ASCO-SITC Clinical Immuno-Oncology Symposium in ...
(Date:2/21/2017)... IDAHO FALLS, Idaho , Feb. 21, 2017 /PRNewswire/ ... is has completed a private placement with certain investors ... preferred stock of the Company, Series C Convertible Redeemable ... Stock accrues dividends at an annual rate of 6% ... share.  The Company plans to use the proceeds for ...
Breaking Medicine Technology: