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USC researchers discover novel way to develop tumor vaccines
Date:3/2/2008

rdian cells of the immune systems and play an important role in activating immune responses to recognize and destroy tumor cells. Tumor vaccines have been designed and developed to incite the immune response to cancer cells so that the immune system can attack and destroy cancer cells. However, discovering A20s role in restricting immune responses has led to a method for blocking tumors from using regulatory T cells for protection.

Despite intensive efforts, tumor vaccines have been largely ineffective in causing tumor regression in the clinic, says Chen. The vaccination approach we developed inhibits the key inhibitor in tumor antigen-loaded dendritic cells to selectively hyperactivate immune responses and to tip the balance from immune suppression in tumor-bearing hosts or cancer patients to effective antitumor immunity.

This approach is capable of overcoming the regulatory T cells suppression mechanism and will allow for a new generation of tumor vaccines to be developed. The next step is to translate these findings into a human clinical trial, says Chen.


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Contact: Jennifer Chan
chanj@usc.edu
323-442-2830
University of Southern California
Source:Eurekalert

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