Navigation Links
USC researchers develop new drug to target tumor cells and blood vessels
Date:4/20/2009

Researchers at the University of Southern California have identified a new drug compound that appears to target tumor cells and surrounding blood vessels without the negative side effects typically associated with Cox-2 inhibitors.

The compound 2.5-dimethyl-celecoxib (DMC) appears to have a strong anti-tumor effect while also attacking the vasculature that provides the blood supply necessary for tumor growth, according to data presented at the AACR 100th Annual Meeting 2009. The findings were presented at a 1 p.m. news conference on Sunday, April 19.

"If left behind, the blood vessels within the tumor will help the tumor cells to survive and re-grow," says Florence M. Hofman, Ph.D., professor of pathology at the Keck School of Medicine of USC. "We believe that DMC will be particularly useful for treating brain tumors such as gliomas, which are highly vascular. It also appears very promising for long-term treatment because it does not have the negative cardiovascular effects associated with Cox-2 inhibitors."

Cox-2 inhibitors are most commonly used as anti-inflammatory drugs and have been shown to be effective in treating certain kinds of cancer. However, long-term use has also been associated with increased risk of heart attack and stroke, Hofman explains. DMC, however, retains anti-tumor activity without inhibition of Cox-2 and the associated increased risk of cardiovascular complications.

Hofman and colleagues from the Keck School of Medicine tested the effectiveness of the DMC compound by isolating endothelial cellsthe cells that line the interior surface of blood vesselsfrom human nonmalignant brain and glioma tissues and treating them with DMC.

They found that the drug was cytotoxic to tumor-associated endothelial cells and suppressed cell proliferation and migration without apparent toxic effects to normal tissues. Drug therapy in animal studies also showed smaller tumors and fewer blood vessels in the tumors, with a 35 to 40 percent reduction in blood vessel density.

"While our research focused on brain tumors, we believe this drug may work in a number of different tumors that are dependent on blood vessels," Hofman says. "Further research will help us to understand its full potential."


'/>"/>

Contact: Meghan Lewit
lewit@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... ... While the practice and profession of Aging Life Care is not new, there ... and resources. Aging Life Care plays an important role as these professionals are prepared ... Care is a holistic, client-centered approach to caring for older adults or others facing ...
(Date:5/5/2016)... ... May 05, 2016 , ... The ... electronic cigarettes, requiring e-cigarette manufacturers to submit their products through an arduous federal ... all vaping products that entered the market since February 15, 2007. That would ...
(Date:5/5/2016)... ... ... This weekend, from Friday, May 6 - Sunday, May 8, fifteen elite athletes from ... Semper Fi Mountain Bike Camp, hosted in conjunction with WTB and Cannondale ... Jason Moeschler, who’ll share pro tips with the injured veterans as they rip down some ...
(Date:5/5/2016)... ... May 05, 2016 , ... LELO has discovered many ... LELO fans reach out via email, social media and on the Volonté blog seeking ... the way I masturbate ‘normal’ or ‘correct’?” , While some methods are more common ...
(Date:5/5/2016)... ... May 05, 2016 , ... An ... all U.S. states and certain Canadian provinces is now available from the International ... Institute (WCRI). , The report, Workers’ Compensation Laws as of January ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... May 6, 2016 Global ... disorders along with rise in obesity will fuel ... the coming few years. The NASH Market is ... years on account of rising number of obesity ... large, un-tapped market with no FDA approved therapeutics. ...
(Date:5/5/2016)... reported initial promising results in animal trials of its Zika vaccine candidates. ... ... ... ... analysis identified the highest gene Replikin Counts in Zika history back to 1946 (1). ...
(Date:5/5/2016)... May 5, 2016  Endo International plc (NASDAQ: ... that Brian Lortie , President, U.S. Branded ... position upon the appointment of a successor. Mr. ... U.S. Pharmaceuticals business with responsibility for all strategic, ... strategy and portfolio development, commercial operations, managed markets, ...
Breaking Medicine Technology: