Navigation Links
USC research finds certain contraceptive may pose risk of Type 2 diabetes for obese women
Date:2/7/2013

Highlights of this news release:

  • Six-month study finds that progestin-releasing contraceptives show a slight negative impact on metabolic markers, raising the risk for type 2 diabetes.

  • Contraceptive implants under the skin increase the risk more than uterine implants.

  • Longer and larger studies are needed to see if metabolic changes are temporary or long-term.

LOS ANGELES A first-of-its-kind study by researchers at the Keck School of Medicine of the University of Southern California (USC) indicates that healthy, obese, reproductive-age women who use long-acting reversible contraception (LARC) containing the hormone progestin have a slightly increased risk for developing type 2 diabetes when compared to those who use non-hormonal contraception.

The research concludes that progestin-releasing LARC appears to be safe for use by such women but needs further investigation.

Nicole M. Bender, assistant professor of clinical obstetrics and gynecology at the Keck School, was the principal investigator for the study "Effects of progestin-only long-acting contraception on metabolic markers in obese women," which appeared online in the journal Contraception on Jan. 2, 2013.

"Contraceptive studies often only look at normal-weight women," said Penina Segall-Gutierrez, co-investigator of the study and an assistant professor of clinical obstetrics and gynecology and family medicine at the Keck School. "Studies such as this are necessary because, today, one-third of women in the U.S. are overweight and one-third are obese. All women, including overweight and obese women, need to have access to safe and effective contraception."

Obese women are at increased risk for pregnancy-related complications and are sometimes warned by their doctors not to use contraceptives containing estrogen, such as the pill, patch and vaginal ring.

"[Those choices] raise the risk for blood clots," Segall-Gutierrez said. "So they need other, viable alternatives. The implanted LARC devices last three to 10 years, are easily reversible, and women don't have to remember to do anything with them, in contrast to the birth-control pill."

The six-month study observed the metabolic markers in three groups of obese women: a control group using non-hormonal birth control methods, including condoms, the copper IUD, and female or male sterilization; a second group with a progestin-releasing LARC device implanted in the uterus (IUD); and a third group with a progestin-releasing LARC device implanted under the skin.

"All three methods were found to be safe and effective, and they did not create changes in blood pressure, weight, or cholesterol," Segall-Gutierrez said. "However, there was a 10 percent increase in fasting blood-glucose levels among the skin implant users, compared to a 5 percent increase among the IUD users and a 2 percent decrease among those using non-hormonal methods. The effects on sensitivity to insulin showed a similar trend. It is unknown if these effects would continue if the devices were used and studied for a longer period of time."

Segall-Gutierrez and her Keck research partners have studied the metabolic effects of other birth-control methods as well. In 2012, they reported findings that obese women receiving a progestin birth-control shot every three months may be at increased risk for developing type 2 diabetes.

"Overall, we're finding that methods such as the progestin injection and the progestin skin implant, which both have higher circulating progestin, may have an increased risk for metabolic changes compared to methods like the IUD, which only has a local effect ─ in the uterus," she said.

Segall-Gutierrez added that the progestin-releasing IUD has other benefits. It is approved by the U.S. Food and Drug Administration for treatment of heavy menstrual bleeding, which often affects obese women. The IUD also protects against endometrial cancer, which disproportionately affects obese women.

"Choosing a birth-control method requires consideration of many factors, including the patient's lifestyle and willingness to use the method, desire for future fertility, and risk for a host of diseases ─ diabetes and endometrial cancer being two of them for obese women," she said. "We would like to expand our most recent study by looking at more participants over a longer period of time to see if the metabolic effects we observed in the progestin-releasing implants persist or are only temporary."

In addition to Bender and Segall-Gutierrez, the research team includes Sandy Oliver Lopez Najera, Frank Z. Stanczyk, Martin Montoro and Daniel R. Mishell.


'/>"/>

Contact: Leslie Ridgeway
lridgewa@usc.edu
323-442-2823
University of Southern California - Health Sciences
Source:Eurekalert

Related medicine news :

1. UCLA Brain Injury Research Center gets NCAA funding for research on sports concussions
2. NIH awards $20 million over 5 years to train next generation of global health researchers
3. Researchers develop a new cell and animal model of inflammatory breast cancer
4. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
5. Sexually abused boys at risk for more unsafe sex: UBC research
6. Researchers Find Gene Mutations That May Be a Key to Autism
7. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
8. Researchers find evidence of banned antibiotics in poultry products
9. Presidential keynote address and new research highlights from the American Society of Pediatric Otolaryngology meeting
10. Scientific session and new research highlights
11. NJ stroke researchers report advances in spatial neglect research at AAN Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... 2017 , ... Wells Pharmacy Network offers physicians WellsPx3, a ... non-controlled substances plus the ability to manage orders on their desktop or mobile ... electronic prescriptions, according to the Office of the National Coordinator of Health IT, ...
(Date:2/17/2017)... ... February 17, 2017 , ... Qualis Health, one of ... the 8th Annual DecisionHealth Platinum Awards in recognition of its innovative healthcare management ... recognized across multiple award categories, highlighting four of the organization’s current programs:, ...
(Date:2/17/2017)... ... February 17, 2017 , ... PrideStaff, a national ... was named to Staffing Industry Analysts' 2017 "Staffing 100 North America" list. ... made notable contributions to the staffing industry over the last twelve months. Industry ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... ... and financial planning assistance to families and business owners in the greater Fort ... 4 Families organization. , For more than 30 years, LifeNet 4 Families ...
(Date:2/16/2017)... Kisco, New York (PRWEB) , ... February 16, ... ... Hospital’s (NWH) nursing professionalism, teamwork and superiority in patient care, NWH has ... of the Commission on Magnet on Tuesday, January 31, 2017. The American Nurses ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... Feb. 17, 2017   Risperdal lawsuits involving gynecomastia ... associated with use of the atypical antipsychotic medication continue ... Court of Common Pleas, where the state,s Risperdal ... According to a notice posted on the Court,s ... meeting on March 9, 2017 at 11:00 a.m. (In ...
(Date:2/17/2017)... Feb. 17, 2017  BioDigital, Inc., creators of ... of their 3D body mapping technology with eClinicalWorks, ... new integration will be used to capture and ... of the human body. BioDigital pilots show using ... while also increasing the precision of clinical annotations ...
(Date:2/16/2017)... -- Research and Markets has announced the addition ... report to their offering. ... Traditional medical devices include devices ... coated implantables, large endoscopes, needle based drug delivery, lab based ... two to three decades for the treatment and management of ...
Breaking Medicine Technology: