Navigation Links
USC research IDs potential treatment for deadly, HIV-related blood cancer
Date:6/25/2013

LOS ANGELES Researchers at the USC Norris Comprehensive Cancer Center have discovered a promising new way to treat a rare and aggressive blood cancer most commonly found in people infected with HIV.

The USC team shows that a class of drugs called BET bromodomain inhibitors effectively targets primary effusion lymphoma (PEL), a type of cancer for which those drugs were not expected to be effective.

"It's a reversal of the paradigm," said Preet Chaudhary, MD, PhD, chief of the Nohl Division of Hematology and Blood Diseases at the Keck School of Medicine of USC and principal investigator of the study. "Our results suggest that this new class of drug may be an effective treatment for a wider range of cancers than previously thought."

PEL is caused by infection with Kaposi's sarcoma-associated herpes virus, the most common cause of cancer among patients with AIDS. The prognosis for PEL is poor, with a median survival of three to six months. Thus, there is a critical need for new therapies for the disease.

Chaudhary and his colleagues show that inhibitors targeting the BRD4 protein blocked growth of PEL cells in a test tube and in a mouse model. The results were surprising because BET inhibitors were thought to be only effective against cancers linked to an overexpression of the Myc gene.

"We actually found that cancers that overexpress Myc are not as responsive to BRD4 inhibitors. PEL is more responsive," Chaudhary said.

Cancers like multiple myeloma and Burkitt's lymphoma overexpress the Myc gene and have been shown to respond to BRD4 inhibitors. In PEL, the Myc gene is moderately expressed and there is no chromosomal translocation as is seen in multiple myeloma or Burkitt's.

More research is needed to create compounds ready for testing in people. Once those drugs are ready for clinical trial, data from this study suggest that they may treat a wide range of cancers. Chaudhary anticipates testing them alone and in combination with other drugs.


'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences
Source:Eurekalert

Related medicine news :

1. MS researchers determine that brain reserve independently protects against cognitive decline in MS
2. New screening approach identifies small proteins unique to melanoma cells, Moffitt researcher says
3. American Brain Tumor Association’s 2013 Patient & Family Conference Highlights Emerging Research
4. Voices Against Brain Cancer Comments on Recent Discovery in Ongoing Brain Cancer Research
5. Ethanol Leads Renewable Chemicals Market; Polymers Sector 14.3% CAGR Growth Forecasted by 2018 Says New Research Report at ReportsnReports.com
6. Arthrex, Depuy Mitek, and Smith & Nephew Lead the $1.5 Billion U.S. Orthopedic Soft Tissue Market, Reports iData Research
7. Citrus, Banana and Other Fruit Growing in Australia Industry Market Research Report Now Updated by IBISWorld
8. Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
9. Going to synagogue is good for health and happiness, Baylor researcher finds
10. Consider a text for teen suicide prevention and intervention, research suggests
11. America will never be gay and lesbian friendly, says researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... ... An inventor from Columbia, S.C., wants to offer people with manual disabilities a ... firework accident, so she couldn’t grip a pen properly," he said. "This inspired me ... created a prototype for the HELPEN HAND, a special pen that enables a person ...
(Date:5/22/2017)... ... May 22, 2017 , ... OSF Ventures, the ... in InsightRX, an early stage company in San Francisco that has developed software ... Greatpoint Ventures Innovation Fund acted as the lead investor in the round. ...
(Date:5/21/2017)... ... May 20, 2017 , ... Pot. Reefer. Grass. Mary Jane. No matter what ... its attributes like never before. More than a map, new social marketplace Weedable ... strains, products – and for the first time – each other. A social marketplace ...
(Date:5/21/2017)... Houston,Texas (PRWEB) , ... May 21, 2017 , ... ... but if it's been longer than six months since you've seen a dentist, ... dentist twice per year and getting x-rays once per year. , Dental checkups ...
(Date:5/19/2017)... ... ... Springfield, Vermont-based law firm of Brady/Callahan has released a new Personal Injury law ... Personal Injury Attorney, " the article offers insight for people who have questions, concerns ... someone is injured due to another person's negligence, they may want to ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... May 8, 2017 MACRA replaces the ... fee for service reimbursement. Black Book Research crowdsource-surveyed 8,845 ... 1.       The Market for MIPS Compliance Technology is ... physician practices with 3 or more clinicians seek to ... Q4. "Given the magnitude of the changes, the hunt ...
(Date:5/4/2017)... 4, 2017  Fortuna Fix Inc. (" Fortuna "), ... first to eliminate the need for embryonic and fetal stem ... neurodegenerative diseases. Fortuna announced today the ... Michael Fehlings , MD, PhD; Father Kevin FitzGerald , ... and Professor James Giordano , PhD. "We ...
(Date:5/4/2017)... 2017  A new tight-tolerance microextrusion medical tubing ... materials, is being launched by Natvar, a Tekni-Plex ... in recent years to service a wide variety ... More expensive materials such as glass and fluoropolymers ... to their ability to consistently hold tolerances. This ...
Breaking Medicine Technology: