Navigation Links
USC neuroscientists awarded $9 million to map gene expression during human brain development
Date:10/2/2009

Two University of Southern California (USC) neuroscientists have been awarded nearly $9 million in American Recovery and Reinvestment Act funds to map how genes are expressed in different regions of the human brain throughout development.

The two-year grant, part of the Grand Opportunities grant program, funded through the National Institutes of Mental Health (NIMH), will allow researchers to use cutting-edge DNA sequencing and profiling technologies to create an atlas of when and where thousands of genes are expressed during key periods of development. The findings will be freely accessible to scientists worldwide and provide a foundation for discovering the origins of mental disorders.

James A. Knowles, M.D., Ph.D., professor of psychiatry at the Keck School of Medicine of USC, and Pat Levitt, Ph.D., director of the Zilkha Neurogenetic Institute at the Keck School of Medicine, will lead the project in collaboration with researchers at Yale University and the Allen Institute for Brain Science in Seattle, Wash.

"This project will allow us to document which individual genes and sets of genes are turned on and off in different brain regions through the whole developmental time period," said Knowles, the principal investigator on the project. "This information is essential for understanding normal and abnormal brain development."

Mental disorders such as autism and schizophrenia are increasingly recognized as brain disorders that have their origins during development. However, relatively little is currently known about how specific genes regulate human brain development, Knowles noted.

"Breaking through the mysteries of the developing human brain and the origins of mental illnesses requires a very large, collaborative effort," co-principal investigator Levitt said. "We are so pleased to be part of an esteemed group of scientists that will produce more information on the human brain than ever before. This will lead to new breakthroughs in determining disease risk and prevention."

Researchers at USC and partner institutions will sequence the genomes from hundreds of brain samples in order to create a three-dimensional, Web-based model that can be used by scientists all over the world as a basis for future neuroscience research.

"This will provide investigators with a fantastically rich resource for future research," Knowles said.


'/>"/>

Contact: Meghan Lewit
lewit@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

Related medicine news :

1. University of Louisville neuroscientists hope to get people walking again
2. Neuroscientists demonstrate link between brainwave acticity and visual perception
3. CSHL neuroscientists propose project to comprehensively map mammalian brain circuits
4. CSHL neuroscientists glimpse how the brain decides what to believe
5. Neuroscientists show insulin receptor signaling regulates structure of brain circuits
6. QBI neuroscientists make Alzheimers disease advance
7. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. $16.8 million grant awarded to develop platelet recovery treatments
10. The Ambrosia Treatment Centers Awarded Gold Seal of Approval by the Joint Commission
11. Winnick Family Scholarship Awarded to Ramona Davoudpour at UCLA School of Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... London, May 23, 2017: Walter Schindler, the Founder ... as a Guest Speaker and Contributor to a weeklong series of classes, meetings, field ... , Walter Schindler and SAIL Capital have received an ...
(Date:5/23/2017)... ... May 23, 2017 , ... Diagnotes, an Indianapolis-based ... standard feature on its secure clinical communication platform. The platform allows clinicians to ... on the type and urgency of a situation. , “We know from ...
(Date:5/23/2017)... ... 2017 , ... Therachat , a smart guided journaling tool for improving ... current state of anxiety in support of National Mental Health Awareness Month. , The ... and benchmarked general anxiety levels as well as identified the top triggers, impact to ...
(Date:5/22/2017)... , ... May 22, 2017 , ... Today, Our Urgent ... MO with a public ribbon cutting ceremony. Since opening over a month ... alternative to the emergency room. The new Our Urgent Care walk-in clinic is ...
(Date:5/22/2017)... CA (PRWEB) , ... May 22, 2017 , ... ... will sponsor a program on Wellocity to empower WeightZone Factor members to track ... medications, and get an excellent health education, all on their mobile phones. It ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... Hologic, Inc. (Nasdaq: HOLX ) announced today ... ended April 1, 2017 .   GAAP diluted earnings ... the prior year period as the sale of the ... non-GAAP diluted EPS of $0.50 increased 6.4%.  Revenue of ... terms.  Excluding the effects of blood screening and the ...
(Date:5/10/2017)... , May 10, 2017  The Corporate ... or employees of sleep therapy clinics to call ... sleep therapy clinic is involved in a substantial ... interested in hearing from an employee of a ... in a kickback scheme to provide medical practice groups ...
(Date:5/10/2017)... Md. , May 10, 2017 CSSi, ... solutions for the clinical research industry, is proud to ... www.CSSiEnroll.com . The new website features both enriched content ... user experience and enhances the company,s already well-established position ... industry. "After many months of hard ...
Breaking Medicine Technology: