Navigation Links
USC dentist links Fosomax-type drugs to jaw necrosis
Date:1/1/2009

Researchers at the University Of Southern California, School Of Dentistry release results of clinical data that links oral bisphosphonates to increased jaw necrosis. The study is among the first to acknowledge that even short-term use of common oral osteoporosis drugs may leave the jaw vulnerable to devastating necrosis, according to the report appearing in the January 1 Journal of the American Dental Association (JADA).

Osteoporosis currently affects 10 million Americans. Fosomax is the most widely prescribed oral bisphosphonate, ranking as the 21st most prescribed drug on the market since 2006, according to a 2007 report released by IMS Health.

"Oral Bisphosphonate Use and the Prevalence of Osteonecrosis of the Jaw: An Institutional Inquiry" is the first large institutional study in the U.S. to investigate the relationship between oral bisphosphonate use and jaw bone death, said principal investigator Parish Sedghizadeh, assistant professor of clinical dentistry with the USC School of Dentistry.

After controlling for referral bias, nine of 208 healthy School of Dentistry patients who take or have taken Fosamax for any length of time were diagnosed with osteonecrosis of the jaw (ONJ). The study's results are in contrast to drug makers' prior assertions that bisphosphonate-related ONJ risk is only noticeable with intravenous use of the drugs, not oral usage, Sedghizadeh said. "We've been told that the risk with oral bisphosphonates is negligible, but four percent is not negligible," he said.

Most doctors who have prescribed bisphosphonates have not told patients about any oral health risks associated with the use of the drugs, despite even short-term usage posing a risk due to the drug's tenacious 10-year half life in bone tissue. Lydia Macwilliams of Los Angeles said no one told her about the risk posed by her three years of Fosamax usage until she became a patient of Sedghizadeh at the School of Dentistry. "I
'/>"/>

Contact: Angelica Urquijo
urquijo@usc.edu
213-271-4189
University of Southern California
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion
2. Coming Soon: Pain-Free Dentistry
3. State Director of Health Commends Ohio Dentists and ODH Bureau of Oral Health for Serving Those in Need
4. Bellevue Dentist Gives a Thumbs Up to Britney Spears Smile
5. San Diego Dentist Haunted by Smiles in Dominican Republic
6. Raleigh Dentist to Bicycle Across North Carolina to Raise Oral Cancer Awareness
7. Roslyn, New York Dentist Elected to Lead American Dental Association
8. Prominent Cosmetic Dentist Dr. William Hoskyns Joins Leading Atlanta Practice
9. Align Technology, Inc. Earns PACE Approval From Academy of General Dentistry
10. American Academy of Implant Dentistry
11. NIH grant advances dentistry schools work on psychosocial stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... (PRWEB) May 24, 2013 KC and Monica ... Title Sponsors for FreeRide836. Their oldest sons, Kyle and Austin ... Tracey Russell family and several professional kiteboarders. , KC Craichy ... project. "This has miraculously come together such that virtually everyone ... to participate." , 20 kite boarders will meet at Matheson ...
(Date:5/24/2013)... The Mirena IUD lawyers at the ... FDA has received more than 59,229 complaints since 2004 from ... birth control device known as the Mirena IUD.* , Among ... the women “included ‘expulsion,’ where the IUD came out on ... to an ABC News article. “Abdominal pain is also common, ...
(Date:5/24/2013)... E-Dentists.com has announced the launch of ... Media Surge, a leading medical Internet marketing agency. ... service will focus on providing dentists the help they ... their competitive keywords. The dental SEO analysis covers a ... on what their competitors are doing right. The goal ...
(Date:5/24/2013)... OR (PRWEB) May 24, 2013 ... Sustainable Cards, major competitors in sustainable card material, ... of using forest materials as a sustainable gift ... is to identify industry challenges and increase education ... card programs to support the reduction of carbon ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Started in 1982, ... held in Orlando. 2013 marks AMTC’s 31st anniversary. SHINE is ... starting with supermodel Millie Lewis and her daughter, Carey Lewis ... agents, managers, casting directors, and music professionals including the New ... and XP Media. They are kings of Hollywood and Christian ...
Breaking Medicine News(10 mins):Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes 2Health News:Dental SEO Analysis Launched by E-Dentists.com in Partnership with JD Media Surge 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 3Health News:AMTC’s Summer SHINE Event Coming to Orlando’s Luxurious Gaylord Palms July 2-7, 2013 2
... for about half of all visits to psychotherapists, and ... with couples.// The therapist helps the couple work on ... perpetuate conflict, explains the March 2007 issue of the ... make little use of psychiatric diagnosis, but they do ...
... of breastfeeding outweigh the risks of virus transmission from HIV-positive ... African nations.// ,A study in Zambia showed ... breast milk ¯ beyond a set time period of ... The study was a collaboration between US universities and University ...
... shows that a form of vitamin A used to treat ... small molecules called microRNAs (miRNAs) in the// leukemic cells. ... miRNAs inhibit the action of two genes important for cancer ... ,The drug is called all-trans-retinoic acid (ATRA) and it ...
... of bioactive compounds in the blood and boost antioxidant ... start// to rival the juice for boosting health. ... rise, particularly in the UK where sales have rocketed ... the antioxidant-rich fruit that has commonly been linked to ...
... in Porirua is not linked to a cluster of cases ... have been treated for typhoid in Porirua and those cases ... of health, regional public health, Wellington, said last night. ... which was being treated very seriously. ,Two of ...
... According to a study published on bmj.com, the second born ... This study also states that there is no big// difference ... second twin born at or after the complete term of ... shortly after birth. ,Many studies have talked about ...
Cached Medicine News:Health News:Breastfeeding Benefits may Outweigh HIV Risk 2Health News:Leukemia Drug Turns Mini-Molecules Up, Cancer Genes Down 2Health News:Science Builds Behind Pomegranate Extracts for Health 2
(Date:5/23/2013)... health affects a man,s lifestyle, and if he wants to ... he should address any hearing loss he may be experiencing. ... Institute (BHI) is delivering to men around the country ... leads up to and includes Father,s Day. This year, National ... To help men address their hearing health ...
(Date:5/23/2013)... HOUSTON , May 23, 2013  A recently ... in Houston, Texas , demonstrates that ... simultaneously increasing cancer detection. The study, ... An Observational Study," was led by Stephen ... June issue of the American Journal of Roentgenology ...
(Date:5/23/2013)... 2013  Hadasit Bio-Holdings Ltd. (TASE: HDST, OTC: ... based on intellectual property developed and owned by ... foremost medical research center, today announced that its ... funding from the Israeli Ministry of Industry and ... support product development and advance clinical trials. Cell ...
Breaking Medicine Technology:Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 2First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 3Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2
... Safety Phase III Results -, LAUSANNE, ... global independent biopharmaceutical development specialist,focusing on serious ... the 9th International Symposium on GnRH in ... study with its new 6-month formulation of,Decapeptyl(R)/Trelstar(R) ...
... Cancer research pioneer Michael,G. Hanna Jr. Ph.D., also ... to OncoVAX(R), a vaccine with the potential to prevent,colon ... represents a major step forward in defeating cancer by,increasing ... has been working,on cancer vaccines for more than 30 ...
Cached Medicine Technology:Clinical Update - Decapeptyl(R)/Trelstar(R) 6-Month Formulation in Advanced Prostate Cancer 2Clinical Update - Decapeptyl(R)/Trelstar(R) 6-Month Formulation in Advanced Prostate Cancer 3Cancer Pioneer Reaches Key Agreement on Colon Cancer Drug OncoVAX(R) 2
... blade. 17 mm wide blade. ... inches. Note: Has Marcks attachment ... to any thickness up to ... thicker grafts or split graft. ...
4 mm blade. Flat handle....
9 mm button end blade. 15 mm long backcutting blade. Angled at 45 degrees. Flat handle. Designated most popular model or size....
10 mm blade, angled left. Flat handle....
Medicine Products: