Navigation Links
USC Norris cancer research ranks among top clinical advances for 2012

USC Norris Comprehensive Cancer Center research that identifies specific genes that have to be turned off in order for cancer cells to survive was named one of the top major advances in cancer research this year by the American Society of Clinical Oncology (ASCO).

The study, "DNA methylation screening identifies driver epigenetic events of cancer cell survival," first appeared in the May 15 issue of Cancer Cell, a peer-reviewed scientific journal. It is one of 87 studies highlighted in Clinical Cancer Advances 2012: ASCO's Annual Report on Progress Against Cancer, available online in the Journal of Clinical Oncology at

The annual report, now in its eighth year, is an independent review of clinical cancer research advances that have the greatest potential to improve patients' survival and quality of life. Compiled and edited under the guidance of 21 renowned experts in specific fields of cancer research, the report describes, in lay language, the most significant advances of the year, offering the public a window into the achievements, trends and challenges in oncology.

The USC study, which appears in the tumor biology section of the report, was led by Peter Jones, Ph.D., D.Sc., distinguished professor of urology, biochemistry and molecular biology at the Keck School of Medicine of USC.

"We want to know what makes a cancer cell a cancer cell," said Jones, an epigenetics pioneer who discovered the mechanism behind the drug 5-azacytidine, which is now standard treatment for a pre-leukemia bone-marrow disorder. "This particular study was the first to track down these genes that, when silenced through DNA methylation, allow the cancer cell to avoid normal death."

DNA methylation, or the addition of methyl groups to a gene, can change gene expression without changing the DNA sequence. This epigenetic process is potentially reversible, making the areas where it happens good targets for new treatments to be developed.

"Our findings essentially pave the way for more effective cancer medicine," said the study's first author, Daniel D. De Carvalho, Ph.D., a USC post-doctoral fellow who now leads a lab at the Ontario Cancer Institute at Princess Margaret Cancer Centre in Toronto. "Our research continues to focus on understanding the epigenetic mechanisms that underlie how tumors are created in order to develop new and more efficient cancer treatments."


Contact: Alison Trinidad
University of Southern California - Health Sciences

Related medicine news :

1. African American women with breast cancer less likely to have newer, recommended surgical procedure
2. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
3. Racial Disparities Still Seen in Use of Breast Cancer Treatments
4. New Drug Regimens May Slow Advanced Breast Cancer
5. Breath test could possibly diagnose colorectal cancer
6. UNM Cancer Center researchers study new target for breast cancer
7. Longer life expectancy, aging population necessitate new strategies for prostate cancer care
8. UK initiates first cancer reporting model of its kind in US
9. Drug shows promise in prostate cancer spread to bone
10. Genetic data shows that skin cancer risk includes more than UV exposure
11. Unexpected toughness may mark out cancer cells in the blood
Post Your Comments:
(Date:11/25/2015)... ... 25, 2015 , ... Privately owned Contract Development and Manufacturing ... its current state of the art research, development and manufacturing facility outside of ... manufacturing capacity as well as to support its clients’ growing research and development ...
(Date:11/25/2015)... , ... November 25, 2015 , ... Many people know ... fuzzy-headedness, weight gain, cold hands, and dry skin. But many people who find their ... and exercise regimen instead of their thyroid, especially if they don’t have any of ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in ... involving adult stem cell therapies to patients with chronic degenerative medical conditions. Now, ... a Registered Trademark (RTM). , Organizations are required to hold a registered trademark ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... prices in an early celebration of the early holiday shopping season. Starting Wednesday ... each (normally $33.95 ea). Black Friday promotional pricing is in addition to any ...
(Date:11/24/2015)... ... November 24, 2015 , ... Eric C. Seidel, DMD ... benefits of the revolutionary BIOLASE WaterLase iPlus 2.0™ system. This advanced laser technology ... by a dentist in Gettysburg, PA . From routine visits to cosmetic ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 Research and Markets ( ... Market - Global Forecast to 2020" report to ... accounting for 37.21% of the total market share in ... region is projected to growth at the highest ... attributed primarily to the fast growing water, industrial gas ...
(Date:11/24/2015)... November 25, 2015 The hope ... repeated failure of IVF cycles. After failure of over ... and had lost all hopes that she would be able to conceive ever. ... child conceived after failure of over 15 IVF cycles. ... before they decided to take one last attempt with Gaudium IVF ...
(Date:11/24/2015)... , Nov. 24, 2015  Natera, ... in non-invasive genetic testing and the analysis ... it will present at the 27 th ... December 2, 2015 at 1:00 p.m. ET.  Matthew Rabinowitz, Ph.D., ... financial results, business activities and financial outlook. ...
Breaking Medicine Technology: