Navigation Links
USC Norris cancer research ranks among top clinical advances for 2012
Date:12/5/2012

USC Norris Comprehensive Cancer Center research that identifies specific genes that have to be turned off in order for cancer cells to survive was named one of the top major advances in cancer research this year by the American Society of Clinical Oncology (ASCO).

The study, "DNA methylation screening identifies driver epigenetic events of cancer cell survival," first appeared in the May 15 issue of Cancer Cell, a peer-reviewed scientific journal. It is one of 87 studies highlighted in Clinical Cancer Advances 2012: ASCO's Annual Report on Progress Against Cancer, available online in the Journal of Clinical Oncology at http://www.jco.org.

The annual report, now in its eighth year, is an independent review of clinical cancer research advances that have the greatest potential to improve patients' survival and quality of life. Compiled and edited under the guidance of 21 renowned experts in specific fields of cancer research, the report describes, in lay language, the most significant advances of the year, offering the public a window into the achievements, trends and challenges in oncology.

The USC study, which appears in the tumor biology section of the report, was led by Peter Jones, Ph.D., D.Sc., distinguished professor of urology, biochemistry and molecular biology at the Keck School of Medicine of USC.

"We want to know what makes a cancer cell a cancer cell," said Jones, an epigenetics pioneer who discovered the mechanism behind the drug 5-azacytidine, which is now standard treatment for a pre-leukemia bone-marrow disorder. "This particular study was the first to track down these genes that, when silenced through DNA methylation, allow the cancer cell to avoid normal death."

DNA methylation, or the addition of methyl groups to a gene, can change gene expression without changing the DNA sequence. This epigenetic process is potentially reversible, making the areas where it happens good targets for new treatments to be developed.

"Our findings essentially pave the way for more effective cancer medicine," said the study's first author, Daniel D. De Carvalho, Ph.D., a USC post-doctoral fellow who now leads a lab at the Ontario Cancer Institute at Princess Margaret Cancer Centre in Toronto. "Our research continues to focus on understanding the epigenetic mechanisms that underlie how tumors are created in order to develop new and more efficient cancer treatments."


'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences
Source:Eurekalert

Related medicine news :

1. African American women with breast cancer less likely to have newer, recommended surgical procedure
2. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
3. Racial Disparities Still Seen in Use of Breast Cancer Treatments
4. New Drug Regimens May Slow Advanced Breast Cancer
5. Breath test could possibly diagnose colorectal cancer
6. UNM Cancer Center researchers study new target for breast cancer
7. Longer life expectancy, aging population necessitate new strategies for prostate cancer care
8. UK initiates first cancer reporting model of its kind in US
9. Drug shows promise in prostate cancer spread to bone
10. Genetic data shows that skin cancer risk includes more than UV exposure
11. Unexpected toughness may mark out cancer cells in the blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2020)... ... March 27, 2020 , ... ... OrthoSC is now offering telemedicine as an alternative approach to seeing their ... practice’s doctors in the comfort of their own home or office using video ...
(Date:3/27/2020)... N.J. (PRWEB) , ... March 27, 2020 , ... ... been reviewed and approved by NJ Top Docs. Dr. Kubeck has been approved ... Board of Orthopaedic Surgery and specializes in Spinal Surgery. , Dr. Kubeck’s ...
(Date:3/22/2020)... ... March 21, 2020 , ... The modular ... Home Builders Association (MHBA), have been working with state and federal officials on ... advocating for greater use of modular construction to address the nation’s affordable housing ...
(Date:3/22/2020)... ... , ... In times of crisis, like the current COVID-19 ... world’s focus is on practical matters - on self-isolation, social distancing, surviving, planning, ... chaos. However, it’s during these times that “self-awareness” is crucial, according to the ...
(Date:3/20/2020)... ... March 21, 2020 , ... The ... together for a day of live discussion and learning online. Experts will provide ... telemedicine, whistleblower laws, the role of boards, fraud, waste and abuse, and privacy ...
Breaking Medicine News(10 mins):
(Date:4/1/2020)... ... 01, 2020 , ... As the coronavirus pandemic spreads, ... accessible primary care, launches its telemedicine platform, AFC/TeleCare, as a solution in this ... virtual visits, allowing our medical providers to easily connect with patients for all ...
(Date:4/1/2020)... , ... April 01, 2020 , ... ... begun producing reusable face shields. As large manufacturers nation-wide scramble to retool their ... do reusing masks or in extreme cases, using hand-sewn masks to protect employees ...
(Date:3/30/2020)... (PRWEB) , ... March 30, 2020 , ... ... with its employees, today announced it has launched a series of survey question ... and gather actionable feedback to inform mission-critical decisions. As the current situation continues ...
Breaking Medicine Technology: