Navigation Links
USC Norris cancer research ranks among top clinical advances for 2012
Date:12/5/2012

USC Norris Comprehensive Cancer Center research that identifies specific genes that have to be turned off in order for cancer cells to survive was named one of the top major advances in cancer research this year by the American Society of Clinical Oncology (ASCO).

The study, "DNA methylation screening identifies driver epigenetic events of cancer cell survival," first appeared in the May 15 issue of Cancer Cell, a peer-reviewed scientific journal. It is one of 87 studies highlighted in Clinical Cancer Advances 2012: ASCO's Annual Report on Progress Against Cancer, available online in the Journal of Clinical Oncology at http://www.jco.org.

The annual report, now in its eighth year, is an independent review of clinical cancer research advances that have the greatest potential to improve patients' survival and quality of life. Compiled and edited under the guidance of 21 renowned experts in specific fields of cancer research, the report describes, in lay language, the most significant advances of the year, offering the public a window into the achievements, trends and challenges in oncology.

The USC study, which appears in the tumor biology section of the report, was led by Peter Jones, Ph.D., D.Sc., distinguished professor of urology, biochemistry and molecular biology at the Keck School of Medicine of USC.

"We want to know what makes a cancer cell a cancer cell," said Jones, an epigenetics pioneer who discovered the mechanism behind the drug 5-azacytidine, which is now standard treatment for a pre-leukemia bone-marrow disorder. "This particular study was the first to track down these genes that, when silenced through DNA methylation, allow the cancer cell to avoid normal death."

DNA methylation, or the addition of methyl groups to a gene, can change gene expression without changing the DNA sequence. This epigenetic process is potentially reversible, making the areas where it happens good targets for new treatments to be developed.

"Our findings essentially pave the way for more effective cancer medicine," said the study's first author, Daniel D. De Carvalho, Ph.D., a USC post-doctoral fellow who now leads a lab at the Ontario Cancer Institute at Princess Margaret Cancer Centre in Toronto. "Our research continues to focus on understanding the epigenetic mechanisms that underlie how tumors are created in order to develop new and more efficient cancer treatments."


'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California - Health Sciences
Source:Eurekalert

Related medicine news :

1. African American women with breast cancer less likely to have newer, recommended surgical procedure
2. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
3. Racial Disparities Still Seen in Use of Breast Cancer Treatments
4. New Drug Regimens May Slow Advanced Breast Cancer
5. Breath test could possibly diagnose colorectal cancer
6. UNM Cancer Center researchers study new target for breast cancer
7. Longer life expectancy, aging population necessitate new strategies for prostate cancer care
8. UK initiates first cancer reporting model of its kind in US
9. Drug shows promise in prostate cancer spread to bone
10. Genetic data shows that skin cancer risk includes more than UV exposure
11. Unexpected toughness may mark out cancer cells in the blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... Calif. (PRWEB) , ... March 24, 2017 , ... ... raised over $100,000 for its innovative EcoQube Frame vertical micro-veggies garden on ... instant demand for the product – with nearly 2,000 consumers (and counting) already ...
(Date:3/24/2017)... ... March 24, 2017 , ... The law firm of Enea, ... pleased to announce Westchester resident Lauren C. Enea has joined the firm as an ... will concentrate her practice in elder law, Medicaid planning and applications, and Wills, Trusts ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate about ... what is often a very difficult and challenging time.” , A Certified Medical ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... inspiring stories about real people of God in congregations across the United States. ... a Presbyterian minister ordained in 1964 who has served congregations in seven states ...
(Date:3/23/2017)... ... , ... The physicians of KSF Orthopaedic Center PA are proud to announce ... is located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside ... patients living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... in Drug Discovery and Diagnostics, 2017 - 2035" report to ... The ... current landscape and future outlook of the growing market of deep ... data revolution, deep learning algorithms have emerged as a novel solution ...
(Date:3/24/2017)... 24, 2017 Today Stock-Callers.com have issued ... are: Neovasc Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards ... SSH ). These companies are part of the Healthcare ... Thursday, March 23 rd , 2017, with the NYSE Health ... health care companies in the S&P 500 were down about ...
(Date:3/24/2017)... INDIANAPOLIS , March 24, 2017  Eli ... today announced plans to invest $850 million in ... span facilities across its U.S. enterprise, including research ... The investments are being driven by demand for ... of potential medicines in development targeting cancer, pain, ...
Breaking Medicine Technology: