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USA's largest ever prostate cancer screening program shows high compliance and consistent results
Date:12/15/2008

7.6% respectively).

  • Both tests were positive in just over 1% of cases (1.2%, 1%, 1.1% and 1.2% respectively).

    Key cancer findings included:

    • 1,902 men (4.9%) were diagnosed with prostate cancer and just over 84% of these (1,603) were picked up as a result of PSA or DRE screening.

    • Just over a third of the cancers were picked up at baseline (34.2%). Cancers picked up at this stage tended to be more serious than cancers picked up later in the screening programme. For example, 5.8% of the cancers at baseline were stages three or four, compared with 1.5% in year three.

    • Cancers picked up at baseline were also more likely to have a higher Gleason score, meaning that the cancer was more aggressive and more likely to be fatal. 34% had a Gleason score of seven to ten at baseline, compared with an average of 25.6% in years one to three.

    • 84% of the men who were diagnosed as a result of PSA screening had a PSA of more than 4ng/mL.

    • But not all the cancer patients had an elevated PSA. DRE picked up a further 16% of cancer cases in patients who had a PSA of less than 4ng/mL.

    • The screening programme picked up 16 cancers per thousand men screened at baseline, 11.5 in year one, 10.8 in year two and 11.1 in year three.

    "There has been much debate about the benefits of PSA screening in the United States" says Professor Andriole. "For example the American Cancer Society, the American Urological Association and the National Comprehensive Cancer Network recommend that normal risk men receive annual PSA screening with DRE from the age of 50.

    "However, the US Preventative Services Task Force and the American College of Physicians - American Society of Internal Medicine do not recommend screening because they feel that clear benefits have not been demonstrated.

    "Our research found that compliance was high with both PSA and DRE screening. It also
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  • Contact: Annette Whibley
    wizard.media@virgin.net
    Wiley-Blackwell
    Source:Eurekalert

    Page: 1 2 3

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