Navigation Links
US study shows that tofacitinib is an efficacious treatment for active RA
Date:5/25/2011

Results of a Phase III study presented today at the EULAR 2011 Annual Congress show that at 6 months, 58.3 percent of patients who had previously not responded to treatment with DMARDs, achieved ACR20 response (a 20 percent improvement in symptoms) when treated with the novel oral Janus kinase inhibitor tofacitinib at 10mg BID compared to 31.2 percent in the placebo group. Significant improvements were also observed in the 5 mg BID dose.

Most adverse events were mild and no new safety signals were reported, according to study authors.

Results of the 12 month multinational study, conducted with 792 patients also show that 36.6% and 16.2% of patients achieved ACR50 and ACR70 responses respectively in the 10mg BID group, a significant improvement in symptoms compared to placebo, where 31.2%, 12.7% and 3.2% of patients achieved ACR 20, 50 and 70 respectively. Significant improvements in the Disease Activity Score physician index (DAS28***) were also observed in the treatment groups compared to placebo, along with improvements in the Health Assessment Questionnaire**** (HAQ) compared to placebo.

"We know that JAK plays a fundamental role in the signalling pathways that regulate RA and interrupting the uncontrolled inflammatory cascades seen in this study provides a novel way of modifying the progression of the disease said Professor Joel Kremer of the Albany Medical College in Albany USA. "Tofacitinib appears to reduce the signs and symptoms of RA very rapidly, and we hope that after carefully considering the benefit/risk equation that this compound will provide an additional valuable treatment option for patients who have experienced an inadequate response to prior treatments."

According to researchers, significant ACR 20, ACR50 and ACR70 responses were seen after 2 weeks of therapy (results not published). Patients received concurrent non-biologic background therapy with DMARDs (including methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, penicillamine and gold, both as single agents and as combination therapies). 81.4% of the 792 patients studied were female, with ages ranging between 50.8-53.3 years. Whilst the majority of adverse events reported were mild (infections and infestations), four deaths were reported in the 5 mg and 10mg BID arms. Four opportunistic infections were also reported.

Results of a separate study shows promising results in several patient subgroups

Results of a further, multinational Phase III tofacitinib study (SAT0243) of 610 patients analysing selected subgroups in the USA have shown that clinically significant efficacy and safety was demonstrated in a number of subgroups investigated, including age, weight, prior DMARD status and the presence of RF / anti-CCP antibodies. Of note, patients who were younger (those aged up to 65 years), slimmer (those weighing less than 50kg), those testing positive to anti-CCP and negative to Rheumatoid Factor showed an improved response to 5mg or 10mg tofacitinib compared to placebo.


'/>"/>

Contact: Rory Berrie
rory.berrie@cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

Related medicine news :

1. Study finds much different work histories for disability rejects, beneficiaries
2. Study Ties Blood Markers to Death Risk in Heart Failure
3. Temple-led study finds widening gap between distracted driving and legislation
4. Brisk walking may help men with prostate cancer, UCSF study finds
5. New study aims to improve long-term treatment for patients with bipolar disorder
6. Medicare improved Canadian doctors salaries: Queens University study
7. IUPUI study first to look at early treatment of depression to reduce heart disease risk
8. A Cultured Man Is a Healthier, Happier Man: Study
9. New study finds that violence doesnt add to childrens enjoyment of TV shows, movies
10. UTMB researcher receives $3 million NIH grant to study aging in Mexico
11. Study finds patient navigation increases colorectal cancer screening in ethnically diverse patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... York, NY (PRWEB) , ... December 02, 2016 ... ... featuring an inspirational interview of two ostomy patients, standing as living proof that ... people suffer from digestive diseases and issues that spike around the holidays. This ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd Regional Conference ... and Spa in Honolulu, offering local frontline clinicians the opportunity to extend their ... The demand for supplemental training related to pain management has surged dramatically in ...
(Date:12/2/2016)... , ... December 02, 2016 , ... "Pro3rd Accents Volume ... editors to create versatile lower third titles with just a few clicks of the ... Volume 2 includes 30 lower third animations. Choose from various styles with accented animations, ...
(Date:12/2/2016)... FL (PRWEB) , ... December 02, 2016 , ... ‘Tis ... are winners of $1,000 each from the National Family Partnership and the Drug Enforcement ... families who decorated their homes and the 10 winning schools who decorated their campuses ...
(Date:11/30/2016)... Beach Gardens, FL (PRWEB) , ... November 30, ... ... in eating disorder and mental health treatment has announced the opening of a ... provides specialized partial hospitalization and intensive outpatient treatment for adults and adolescents, both ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 Orthopedic Implants (Including Spinal Implants, ... to Gain a Significant Market Share Owing to a Large ... ... According to a new report by Persistence ... Packaging: Clamshell Product Type Segment Projected to Witness a Significantly ...
(Date:12/2/2016)... , Dec. 2, 2016   CytoSorbents Corporation ... commercializing its European Union approved CytoSorb ® cytokine ... surgery patients worldwide, announced that Dr. Phillip Chan ... 9th Annual LD Micro Main Event investor conference ... at the Luxe Sunset Boulevard Hotel in ...
(Date:12/2/2016)... On Thursday, the NASDAQ Composite ended the trading ... edged 0.36% higher, to finish at 19,191.93; and the S&P ... as six out of nine sectors ended the day in ... Services equities: Myriad Genetics Inc. (NASDAQ: MYGN ), ... Inc. (NASDAQ: INCR ), and La Quinta Holdings ...
Breaking Medicine Technology: