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US Department of Defense helps move spinal cord injury treatment closer to clinical trials
Date:6/21/2010

CD11d is required by white blood cells to leave the bloodstream and enter the injured spinal cord. The anti-CD11d antibody is designed to block that process. By blocking the entry and retention of these white blood cells at the site of injury, the researchers successfully reduced inflammation and improved neurological recovery in preclinical models of spinal cord injury.

The research at Robarts so far has employed a mouse antibody that recognizes human CD11d. This new award from the Spinal Cord Injury Research Program funded by the Department of Defense Congressionally Directed Medical Research Program will support the development of a humanized antibody suitable for use in a clinical trial. This research will be carried out in conjunction with Eli Lilly and Company.

The spinal cord injury team at Robarts has been working on this project for a decade. "This project highlights the importance of peer-reviewed funding in producing new discoveries in neuroscience and the subsequent role of university-industry partnerships in commercializing such technologies," says Ravi Menon, Deputy Director of Robarts. "Robarts continues to excel at all aspects of the discovery cycle, with the rigorously evaluated results benefitting patients and creating commercial value."


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Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

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