Navigation Links
US Department of Defense helps move spinal cord injury treatment closer to clinical trials
Date:6/21/2010

The United States Department of Defense Spinal Cord Injury Research Program has announced a grant of more than a million dollars U.S. to support research at the Robarts Research Institute at The University of Western Ontario (Western). The spinal cord injury research team of Gregory Dekaban, Arthur Brown, Lynne Weaver and Paula Foster, in collaboration with Brian Kwon of the University of British Columbia and Kyle Petersen of the U.S. Naval Medical Research Center, is working on a new therapy designed to limit the damage caused by inflammation immediately following spinal cord injury. The grant will move their work, led by Dekaban, closer to a clinical trial.

Nearly a quarter of wounded military personnel requiring evacuation from the field suffer spinal cord or traumatic brain injury. As well, 12,000 new cases of spinal cord injury occur every year in the North American civilian population. Spinal cord injury creates physical, psychological and financial challenges to the injured and their families. These injuries are also a significant burden for health care systems.

Spinal cord injury occurs in two stages. The first is the physical injury from trauma; the second stage, that extends the initial damage, is caused in large part by inflammation in the spinal cord. "This antibody therapy is designed to be given by intravenous injection as soon as possible after a person comes into the emergency department with a spinal cord injury, or at least within 24 hours," explains Dekaban, a Robarts Scientist in the Molecular Brain Research Group and Professor in the Department of Microbiology and Immunology at Western's Schulich School of Medicine & Dentistry. "In our preclinical models, it's been shown to make a significant improvement in recovery. This antibody treatment could also be effective for traumatic brain injury. "

The antibody targets a protein known as CD11d on the surface of inflammatory cells that circulate in blood. CD11d is required by white blood cells to leave the bloodstream and enter the injured spinal cord. The anti-CD11d antibody is designed to block that process. By blocking the entry and retention of these white blood cells at the site of injury, the researchers successfully reduced inflammation and improved neurological recovery in preclinical models of spinal cord injury.

The research at Robarts so far has employed a mouse antibody that recognizes human CD11d. This new award from the Spinal Cord Injury Research Program funded by the Department of Defense Congressionally Directed Medical Research Program will support the development of a humanized antibody suitable for use in a clinical trial. This research will be carried out in conjunction with Eli Lilly and Company.

The spinal cord injury team at Robarts has been working on this project for a decade. "This project highlights the importance of peer-reviewed funding in producing new discoveries in neuroscience and the subsequent role of university-industry partnerships in commercializing such technologies," says Ravi Menon, Deputy Director of Robarts. "Robarts continues to excel at all aspects of the discovery cycle, with the rigorously evaluated results benefitting patients and creating commercial value."


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Related medicine news :

1. Department of Labor Raises the Bar
2. Hospital Physician Partners and Lock Haven Hospital Announce New Emergency Department Partnership
3. US Department of Education Financial Aid Approval
4. 2 studies: Social factors, super users and urban emergency departments
5. Florida Department of Health Launches Redesigned Website for HIV Campaign
6. Zvetco Biometrics Delivers Needed Authentication for New York City Department of Health and Mental Hygiene
7. Florida Departments of Agriculture and Education Join Florida Dairy Farmers and NFL to Improve Health and Wellness in Florida Schools
8. Jefferson physician named 2010 Emergency Department Director of the Year
9. Dying cancer patient visits to emergency departments can be avoided
10. Netball Australia Joins Forces with DealsDirect.com.au, Australia's Leading Online Department Store
11. Justice Department Files for Immediate Relief Regarding Conditions at Conway Human Development Center, in Conway, Arkansas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2020)... ... September 01, 2020 , ... Board certified ... Glendale. While the office will be the first to bear her name, Dr. ... augmentation (Brazilian butt lift), as well as rhinoplasty, facial rejuvenation, and many more ...
(Date:9/1/2020)... NAPLES, Fla. (PRWEB) , ... September 01, 2020 ... ... and Reconstructive Surgeon with specialty fellowship training in aesthetic surgery of the face, ... Gill, MD – the only female-owned premier boutique plastic surgery and aesthetic practice ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical distributor ... first responders across the United States. Since the start of the global COVID-19 ... medical centers , hospitals , firefighters , and public ...
(Date:8/31/2020)... ... August 31, 2020 , ... Smile Brands Inc., one ... the United States, today announced the grand opening of another affiliated Bright ... will enjoy convenient hours, a comfortable office, and full-service care at the new ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang ... persons with autism and other developmental disabilities, as well as supporting staff in ... adolescents with autism, school consultation, and staff development. She joined the company in ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... Bleep LLC, maker of the ... apnea patient, is the company’s new spokesperson. , “In my line of work, a ... I found the Bleep DreamPort it was a Bleeping no brainer for me,” said ...
(Date:8/27/2020)... ... August 27, 2020 , ... Bridge To A Cure Foundation announces ... an adult and pediatric neuro-oncologist who serves on the Board of Directors at The ... Duke University Medical School. , Internationally recognized, Dr. Friedman is a widely published author ...
(Date:8/26/2020)... Ill. (PRWEB) , ... August 26, 2020 , ... ... infographic: How Chiropractic Care Helps Sports Injuries. The infographic breaks down ways that ... a quicker, healthier recovery. , According to ScripHessco “Athletes have an unusual amount ...
Breaking Medicine Technology: