Navigation Links
US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
Date:7/16/2012

Baltimore, Md., July 14, 2012 U.S. Army researchers made a surprising discovery while examining the impact of an anterior cruciate ligament (ACL) tear (a common knee injury), on four serum biomarkers associated with cartilage health. The researchers found that pre-injury concentrations for all but one of the four serum biomarkers studied were associated with the subsequent likelihood of ACL injury. The findings were presented today at the annual meeting of the American Orthopaedic Society for Sports Medicine (AOSSM).

"We expected to see post-injury differences in biomarkers, but were astonished that the biomarkers showed measurable differences months or years prior to injury," said U.S. Army Lt. Col. Steven Svoboda, M.D., during his presentation, titled The Association between Serum Biomarkers of Cartilage Turnover and Subsequent Anterior Cruciate Ligament Rupture. "If we can identify people predisposed to ACL tears, one day we may be able to prevent injuries before they occur."

Svoboda, an orthopedic surgeon at Keller Army Community Hospital in West Point, N.Y., is director of the John A. Feagin, Jr., Sports Medicine Fellowship and head team physician for the West Point football program. Svoboda presented the Army research findings at the AOSSM's O'Donoghue Sports Injury Research Award Presentation. This award is given annually to the best overall paper that deals with clinical based research or human in-vivo research.

Researchers measured pre-injury levels of four biomarkers of cartilage turnover and metabolism in 45 ACL-injured subjects and 45 control subjects who were matched to the injured subjects by height, sex, weight and age to see if there were differences. Pre-injury samples for all subjects were stored in the Department of Defense Serum Repository, which maintains serum samples drawn from service members at various points during their military careers.

They found that small differences (1 nanogram/milliliter) in pre-injury levels of three of the four biomarkers were associated with being more likely to sustain a subsequent ACL injury than the control group. In fact, an increase in one biomarker was associated with being 19 times more likely to sustain a later injury.

ACL tears are endemic, with 150,000 ACL injuries in the U.S. each year among military personnel, athletes and others with physically demanding careers or pursuits. Several recent studies have shown that high-risk biomechanical movement patterns, specifically excessive knee valgus angle during landing or landing knock-kneed causes increased pressure on the joint. "Our study adds to existing knowledge by raising the possibility of a link between risky movement patterns and biochemical processes associated with cartilage metabolism," added Dr. Svoboda. "Coaches and athletic trainers of the future may help athletes with high biomarker levels reduce their risk of ACL injury by improving their balance and motor control or correcting how they jump and land."

The study also has implications for the study of post-traumatic osteoarthritis (PTOA) because a high percentage of those who experience ACL tears go on to develop PTOA. An imbalance in the ability of cartilage to regenerate itself has been theorized as a critical component in the development of osteoarthritis.

The ACL injured cases for this study were 45 of 71 subjects from an existing clinical trial comparing outcomes for ACL reconstructions performed with two different autograft techniques. Patients were predominately male (86.7 percent) with a mean age of 20.26 years. The study was supported by a grant from the Orthopaedic Research & Education Foundation.


'/>"/>
Contact: Zina Poletz
zpoletz@webershandwick.com
612-719-2024
Weber Shandwick Worldwide
Source:Eurekalert

Related medicine news :

1. Platelet-rich plasma therapy a safe option for cartilage damage, new study finds
2. Using biomarkers to identify and treat schizophrenia
3. Novel biomarkers reveal evidence of radiation exposure
4. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
5. Biomarkers can reveal IBS
6. Oral contraceptive use in girls and alcohol consumption in boys are associated with increased BP....
7. Decreasing cancer risk associated with inflammatory bowel disease
8. Antibodies from rabbits reduce risks associated with unrelated donor stem cell transplantation
9. Antibodies from rabbits reduce risks associated with
10. Obesity, larger waist size associated with better outcomes in heart failure patients
11. A high intake of certain dietary fats associated with lower live birth rates in IVF
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite ... program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the ... a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, ... retirement havens have extremely low property-tax rates, which contributes to the relatively lower ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical (AVACEN) ... is now successfully helping those with the widespread pain ... Fibromyalgia diagnosed Amanda in Essex, England ... washing my hair, experiencing no sleep at all, tremendous ... spasm… I cannot recommend [the AVACEN 100] enough, how ...
Breaking Medicine Technology: