Navigation Links
URMC researchers exploring keys to melanoma progression
Date:7/20/2011

Melanoma is devastating on many fronts: rates are rising dramatically among young people, it is deadly if not caught early, and from a biological standpoint, the disease tends to adapt to even the most modern therapies, known as VEGF inhibitors. University of Rochester researchers, however, made an important discovery about proteins that underlie and stimulate the disease, opening the door for a more targeted treatment in the future.

This month in the journal Cancer Research, Lei Xu, Ph.D., assistant professor of Biomedical Genetics at the University of Rochester Medical Center, proposed that a receptor called GPR56 which mostly has been studied in the context of brain formation -- has an important role in cancer progression.

Xu and colleagues believe they are the first to show the biological mechanisms of how GPR56 relates to the growth and spread of melanoma, and might even be responsible for triggering one of the lethal processes of cancer progression, known as angiogenesis.

"We are very excited about this work because not only did we find an important new factor in melanoma, but we have also shown the signaling pathways through which these G-protein coupled receptors could impede cancer cell growth," Xu said. "Perturbing these pathways could potentially lead to more effective treatments for malignant melanoma."

Melanoma killed an estimated 8,700 people in the United States in 2010, and in the last 25 years the incidence has been increasing to the point that it is now the most common form of cancer in young adults 25 to 29, and the second most common cancer among people in their teens and early 20s.

If diagnosed at an early stage the survival rate is 99 percent; however, the survival rate falls to 15 percent for people with advanced melanoma. One of the challenges is relapse. Even when melanoma is successfully controlled for a significant period of time, the disease can recur and act more aggressively
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. University of Maryland researchers discover possible drug targets for common non-Hodgkins lymphoma
2. RI Hospital researchers find common test may be unnecessary for bariatric surgery candidates
3. Over half of Alzheimers cases may be preventable, say researchers
4. Penn researchers find neural signature of mental time travel
5. Researchers identify how a gene linked to both Alzheimers disease and type 2 diabetes works
6. NYU researchers develop compound to block signaling of cancer-causing protein
7. Mayo researchers: Genetic mutation linked to Parkinsons disease
8. Researchers Closer to Developing Universal Meningitis B Vaccine
9. Novel Virus Jumped From Monkeys to Humans, Researchers Find
10. Dentists can identify people with undiagnosed diabetes, Columbia researchers show
11. UAB researchers present a study on the psychological adaptation of adopted children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), Unionville’s ... new study providing evidence on the impact of 100% ... , Sufficient enough evidence already exists showing a negative ... drinks, with the onset of tooth decay. One question ... as 100% fruit juice, meaning it is completely natural ...
(Date:12/15/2014)... 2014 SIMpalm, a leading mobile ... for iPhone for its client, which allows users to ... company, specialized in finding the right wine. At ... uses combined sensory, chemistry and wine information. All this ... “wine fingerprint.” Those wines that are close counterparts to ...
(Date:12/15/2014)... 2014 Health Dialog, a leading ... that it has received Patient Oriented Accreditation from ... its Disease Management (DM) Programs for asthma, congestive ... heart disease and diabetes. This marks the 12th ... Dialog’s Disease Management (DM) Programs, reaffirming Health Dialog’s ...
(Date:12/15/2014)... Expert pilots process visual information more efficiently than less ... during landings, a new study shows. Landing is ... master, and 36 percent of all airplane crashes and ... and landing. Researchers monitored the brain activity of ... they were at the controls of a flight simulator. ...
(Date:12/15/2014)... Kathy McAfee, America's Marketing Motivator, was announced ... the category of Best Blog 2014. McAfee received the ... career blog Networking Ahead which combines many ... their talent and influence through better networking, leadership and ... Networking Ahead for Business, has been motivating readers for ...
Breaking Medicine News(10 mins):Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News:Health Dialog Receives NCQA Accreditation for Disease Management Programs 2Health News:Study Shows Why Expert Pilots Are Experts 2Health News:Kathy McAfee, America’s Marketing Motivator, Wins Best Blog from Women World Awards 2
... cancer cases in 2003.// Researchers have been mulling over the ... their attention. Nearly millions of women had abandoned hormone replacement ... out such a huge difference, is being debated over. ... the number of breast cancer cases, estimated at 14,000 women ...
... people with history of unprotected sex to have an ... transmission.// The announcement being the first case of such ... Thursday uncovered two clusters of HIV infections, HIV-1 subtype ... government scientists. They said that both the clusters found ...
... gas tragedy survivors' organisations claimed //to have seized a ... medical stores of the Bhopal Gas Tragedy Relief and ... organisations, working for the victims of the world's worst ... their expiry date," Rachna Dhingra of Bhopal Group of ...
... researchers at the University of Pennsylvania Health System are ... the heart when its electrical pulses// essentially short-circuit, referred ... problem physicians run into with current therapies to cope ... pulmonary vein isolation procedures, is that up until now, ...
... the limit,’ but subsequently found to be below maximum permissible ... drugs, reveals research in Injury Prevention. ,The findings ... all drivers who are suspected of being over the limit ... 2000 blood and urine specimens taken from drivers who had ...
... a man’s heart is through his stomach, they say! Is that ... for thought, of course! Meanwhile, what could be the route to ... the lady of the house, says a new study. ... study of almost 200 British men and women, who were on ...
Cached Medicine News:Health News:New Tool Being Tested to Halt Recurrence of Atrial Fibrillation 2Health News:One in Three Drivers Under ‘The Limit’ for Alcohol Still Test Positive for Dru 2Health News:How a Woman Holds Fort in Her Little Kingdom – The Kitche 2
(Date:12/15/2014)... MEADOWS, N.Y. , Dec. 15, 2014 ... the SPL (Structured Product Labeling) markup language standard, content ... the understanding and skills to work with the standard. ... a series of three webinars on the benefits and ... three one-hour webinars will be facilitated by Howard ...
(Date:12/15/2014)... , Dec. 15, 2014  The Government of Ghana ... AABB, Global Blood Fund (GBF) and Terumo BCT to respond to ... as well as provide long-term health system capacity to the citizens ... , The Ghanaian Ebola Readiness and Resilience Initiative (GERRI) is ... preparations for the possible arrival of the Ebola epidemic ...
(Date:12/13/2014)... Research and Markets ( http://www.researchandmarkets.com/research/2r6bmg/drug_injection ... "Drug Injection Devices to 2020" report to ... As new drugs become available ... health conditions, drug developers have increasingly pursued packaging ... and increase the efficiency and reliability with which ...
Breaking Medicine Technology:Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 2Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 3Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 4Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 5Government of Ghana Endorses Collaboration to Combat Ebola Epidemic 6Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4
... Feb. 28, 2011 Mylan Inc. (Nasdaq: MYL ... received final approval from the U.S. Food and Drug Administration ... Capsules USP, 100 mg, 300 mg and 400 mg, the ... treat a painful complication of shingles. Gabapentin ...
... SHENZHEN, China, Feb. 28, 2011 /PRNewswire-Asia/ -- Winner ... "Winner Medical"), a leading manufacturer of medical dressings, ... natural PurCotton® products in China, announced today that ... Rodman & Renshaw Annual China Investment ConferenceDate: , ...
Cached Medicine Technology:Winner Medical to Attend Investor Conferences in March 2Winner Medical to Attend Investor Conferences in March 3Winner Medical to Attend Investor Conferences in March 4
... Raintree Billing Manager and Collections Administrator ... or de-centralized billing models and personalized ... ratios with the ability to facilitate ... claims more directly from the Onscreen ...
H2003 manage your patient records and billing processes via the Web....
... Billing system allows a practice to ... is integrated with the EMR, appointment ... interfaces with electronic clearinghouses for electronic ... set of reports, it presents practice ...
... athenaCollector™ is athenahealth's ... management solution. It provides ... billing capabilities in the ... claims and billing processes ...
Medicine Products: