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URI scientists reveal mechanism that regulates cancer-causing gene
Date:3/26/2009

et how Src responds to this regulation has remained elusive.

The URI scientists took a systematic approach, examined all the potential mechanisms, and identified the sensor that enables Src to respond to ROS regulation. They further found that the sensor is also present in several other similar enzymes, mostly in the FGFR family.

"Our results were surprising at first, given that the results contradict some reports in the literature," Kemble said. "But there was always a very clear answer to each question we asked. It was both unusual and exciting to see things progress as smoothly as it did."

According to Sun, this mechanism of regulation represents just a small piece of the large puzzle of how Src is controlled in the cells. "Src function is under the control of several different mechanisms; each one needs to fit in with the others to form a seamless regulatory system." Sun said.


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Contact: Todd McLeish
tmcleish@uri.edu
401-874-7892
University of Rhode Island
Source:Eurekalert

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