Navigation Links
URI research couple's method targets cancerous tumors
Date:10/27/2009

KINGSTON, R.I. -October 27, 2009Two University of Rhode Island associate professors, biophysicists Yana Reshetnyak and Oleg Andreev, have discovered a technology that can detect cancerous tumors and deliver treatment to them without the harming the healthy cells surrounding them, thereby significantly reducing side effects. The URI couple has attracted more than $6 million in grants in four years. In addition, a number of health care and pharmaceutical companies have expressed interest in their work.

It is possible, says Andreev, that one day their detection method could be used as a universal procedure, similar to mammography or colonoscopies. Their harmless imaging test could locate a problem before the patient ever feels ill.

The key lies in the acidity level of cells. While normal cells maintain a pH of 7.4 with little variation, cancer cells, expend a great deal of energy as they rapidly proliferate, pumping protons outside and creating an extracellular pH level of 5.5 to 6.5. (The lower the number, the higher the acidity.)

While scientists have known about tumor acidity for years, they had not devised a way to target it. Donald Engelman in the molecular biophysics and biochemistry lab at Yale University discovered the peptide that targets acidity, but had not employed it until Reshetnyak joined his lab as a postdoctoral student in 2003. She and Andreev, then a senior scientist at an anticancer drug delivery company, suggested an investigation into the peptide's potential as cancer targeting agents.

In 2004, Reshetnyak and Andreev joined the Physics Department at URI and established a biological and medical physics laboratory. The couple continued their collaboration with Engleman and their investigation of the properties of the peptide, now called the pHLIP peptide. After making some modifications to it, they demonstrated that pHLIP could find a tumor in a mouse and deliver imaging or therapeutic agents specifical
'/>"/>

Contact: Jan Wenzel
wenzel@advance.uri.edu
401-874-2116
University of Rhode Island
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... (PRWEB) August 31, 2014 MYMOBILEUNI ... community utilizing social media marketing tools access to ... programs. MMU will utilize all tools to reach ... partner for our multiple learning channels. , MMU, ... app, and an authoring tool that applies social ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 Just in time ... serving up only wild, sustainable Alaska Salmon, award winning ... at the Duke's Green Lake location , Sunday, September ... expect to sample several ethnic salmon BBQ culinary delights. Live ... Salmon recipes from Hawaii, Puerto Rico and Mexico will be ...
(Date:8/31/2014)... Mesa, Arizona (PRWEB) August 31, 2014 For ... ragweed is likely the culprit. Ragweed is the most common ... percent of Americans. , The most common symptoms of ragweed ... and throat, and sneezing. Ragweed allergy can also lead to ... ragweed allergies should consult an allergist about allergy immunotherapy - ...
(Date:8/31/2014)... years of hard work, Delta has now become one of ... company has updated its wheel loader assortment with ... items are guaranteed to be great. Additionally, they are offered ... true that all items in Delta’s used cat 966 ... firm is making full efforts to help worldwide customers to ...
(Date:8/31/2014)... In the wake of growing consumer concerns ... to require mandatory labeling of GMOs on food and ... that affect their own health and the health of ... measures to eliminate GMOs from dietary supplements, NutriGold has ... initiative with the objective of advancing the non-GMO ...
Breaking Medicine News(10 mins):Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 2Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 3Health News:Seattle Seafood Restaurant Duke's Chowder House on Green Lake Will Celebrate The Long Anticipated Indian Summer With First Annual Sizzling BBQ Salmon Tasting Event. 2Health News:AllergyEasy Announces Success Helping Patients Build Immunity To Autumn Ragweed Pollens With Under-the-tongue Drops 2Health News:AllergyEasy Announces Success Helping Patients Build Immunity To Autumn Ragweed Pollens With Under-the-tongue Drops 3Health News:Delta Updates Its Wheel Loader Assortment With A Lot Of Cheap Used Cat 966 Loaders 2Health News:NutriGold Announces its I.C.E. Initiative to Educate Consumers about GMOs in Dietary Supplements 2Health News:NutriGold Announces its I.C.E. Initiative to Educate Consumers about GMOs in Dietary Supplements 3
... cancer treated with a newer technology, intensity modulated radiation ... fewer late bowel and rectal side effects and a ... and rectum, compared to those who undergo 3D-CRT, according ... October 3, 2011, at the 53rd Annual Meeting of ...
... 26 2011) Researchers in Japan have completed a study ... dental pulp can be grafted and produce bone regeneration between ... issue of Cell Transplantation (20:7), now ... for a number of reasons, and autogenous bone grafting - ...
... one form of albinism? Individuals with oculocutaneous ... and light-colored irises because they have none, or very little, ... Affected individuals have impaired eyesight and a substantially increased risk ... to correct eyesight and counseling to promote the use of ...
... HealthDay Reporter , MONDAY, Sept. 26 (HealthDay News) -- ... diabetes and asthma have an especially tough time keeping ... The reason why asthma might complicate pediatric diabetes ... to be explored more," said Dr. Anita Swamy, a ...
... the National Midwifery Week Celebration at Women & Infants ... the president of the American College of Nurse-Midwives (ACNM), ... "With Women for A Lifetime" commendation to the Women,s ... that have provided innovative and compassionate midwifery care to ...
... family history of breast cancer, but no genetic link, are not ... with a strong family history of breast cancer, but no genetic ... in their efforts to manage the risk, leading some women to ... has found. The study was led by Dr Louise Keogh ...
Cached Medicine News:Health News:IMRT has less harmful rectal side effects than 3D-CRT for prostate cancer patients 2Health News:Cell Transplantation study shows bone growth from implanted tooth and dental pulp stem cells 2Health News:JCI online early table of contents: September 26, 2011 2Health News:JCI online early table of contents: September 26, 2011 3Health News:JCI online early table of contents: September 26, 2011 4Health News:JCI online early table of contents: September 26, 2011 5Health News:JCI online early table of contents: September 26, 2011 6Health News:JCI online early table of contents: September 26, 2011 7Health News: Asthma Can Complicate Diabetes Care in Kids 2Health News: Asthma Can Complicate Diabetes Care in Kids 3Health News: Asthma Can Complicate Diabetes Care in Kids 4Health News:Women with breast cancer with no genetic link, are not fully utilizing breast cancer services 2Health News:Women with breast cancer with no genetic link, are not fully utilizing breast cancer services 3
(Date:8/29/2014)... -- Does your doctor know what you,re smoking?  Chances are, ... to the over 112,000 currently registered patients under ... other roughly 20,300+ active physicians listed with the Colorado Dept ... even though a poll in February 2014 showed 51% of ... it. "With marijuana legalization underway, every doctor ...
(Date:8/29/2014)... WASHINGTON , Aug. 29, 2014 Diseases ... a generation ago are returning. Measles was declared ... cases in 2014 as of August 15—the highest incidence ... public health department declared whooping cough a problem ... children are getting sick and dying from these preventable ...
(Date:8/29/2014)...  Abaxis, Inc. (NasdaqGS: ABAX ), a ... to the medical, research and veterinary markets, announced today ... Officer, will present at the CL King 12 th ... 9, 2014 at 12:30 p.m. ET. The conference will ... New York City . ...
Breaking Medicine Technology:Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2
... new post hoc analyses assessing the effects of Neupro® ... utilizing novel surrogate markers suggested improved daytime functioning and ... depressive symptoms in patients with moderate to severe RLS. ... of Parkinson,s disease and Movement disorders in Toronto, Canada. ...
... (NASDAQ: VOLC ), a leading developer and ... designed to enhance the treatment of coronary and peripheral ... in the William Blair & Company 31st Annual Growth ... presentation by Scott Huennekens, president and chief executive officer, ...
Cached Medicine Technology:New Post Hoc Analyses Examined the Effects of Neupro® (Rotigotine Transdermal System) on Daytime Functioning, Daytime Symptoms, Pain and Mood in Restless Legs Syndrome 2New Post Hoc Analyses Examined the Effects of Neupro® (Rotigotine Transdermal System) on Daytime Functioning, Daytime Symptoms, Pain and Mood in Restless Legs Syndrome 3New Post Hoc Analyses Examined the Effects of Neupro® (Rotigotine Transdermal System) on Daytime Functioning, Daytime Symptoms, Pain and Mood in Restless Legs Syndrome 4New Post Hoc Analyses Examined the Effects of Neupro® (Rotigotine Transdermal System) on Daytime Functioning, Daytime Symptoms, Pain and Mood in Restless Legs Syndrome 5New Post Hoc Analyses Examined the Effects of Neupro® (Rotigotine Transdermal System) on Daytime Functioning, Daytime Symptoms, Pain and Mood in Restless Legs Syndrome 6New Post Hoc Analyses Examined the Effects of Neupro® (Rotigotine Transdermal System) on Daytime Functioning, Daytime Symptoms, Pain and Mood in Restless Legs Syndrome 7
... The Rusch QuickTrach allows ... ventilation in the presence of ... airway obstruction. The kit consists ... unit with a 10-milliliter syringe ...
... kit includes a guarded scalpel, introducer, tracheal ... and a 10fr suction catheter., ,The ... needed to perform a cricothyrotomy., ,With ... cannula (4.0 mm I.D.) is inserted into ...
Used for emergency airway access when endotracheal intubation cannot be performed. Supplied sterile in peel-open packages. Intended for one-time use....
... Steel. Non-Sterile Howland lock handle - Chrome-plated ... high quality standard laryngoscope handles that are ... ISO 7673 standards. The designs of these ... years of use the world over to ...
Medicine Products: