Navigation Links
UNC team describes novel inflammatory protein function
Date:8/6/2012

A UNC-led team of scientists describes the function of a previously uncharacterized protein that dramatically influences inflammation.

A majority of the NLR family of proteins function as activators of inflammation. However, scientists at UNC report that a newly identified NLR protein, NLRC3, was able to inhibit a major inflammatory pathway that is controlled by a protein called NF-Kappa B. NF-Kappa B activation has been long associated with inflammation and cancer promotion. Their article appears in the August 5,2012 online publication of the journal Nature Immunology.

The UNC team previously reported that another NLR family member, NLRP12, was also able to inhibit NF-Kappa B activation. However, in their new study, the team reported that NLRC3 inhibits this major inflammatory pathway through a completely different mechanism. The researchers show that NLRC3 directly interacts with the molecule TRAF6 and forms a novel, previously uncharacterized protein complex described as a 'TRAFasome'. TRAF6 is a key regulator of NF-kappaB and is a critical step in the regulation of inflammation.

In pre-clinical models, the team was able to show that NLRC3 and the formation of the TRAFasome was important in regulating the immune response during endotoxic shock, a serious hyperinflammatory process typically associated with severe infection.

Monika, Scheneider, first author of the paper and a postdoctoral research associate at UNC Lineberger Comprehensive Cancer Center, explains, "Our research reveals greater insight into the mechanisms controlling inflammation and identifies potential therapeutic targets."


'/>"/>
Contact: Dianne G. Shaw
dgs@med.unc.edu
919-966-7834
University of North Carolina Health Care
Source:Eurekalert

Page: 1

Related medicine news :

1. Jeffrey W. Olin, DO, authors study that describes symptoms and severity of fibromuscular dysplasia
2. New report describes 7 essential steps toward an AIDS-free generation
3. NIH team describes protective role of skin microbiota
4. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
5. Rutgers team discovers novel approach to stimulate immune cells
6. Novel drug candidates offer new route to controlling inflammation
7. Researchers present new findings for novel pancreatic cancer vaccine
8. Novel biomarkers reveal evidence of radiation exposure
9. VCU Massey Cancer Center sees potential in novel leukemia treatment
10. Study supports urate protection against Parkinsons disease, hints at novel mechanism
11. Novel Natural Sciences Repository Opens Web Portal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... the first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am ... caregivers during what is often a very difficult and challenging time.” , A ...
(Date:3/24/2017)... ... March 24, 2017 , ... “Vintage and Harvest A Cultivation of ... college Bible teacher residing in North Carolina with his wife, Anna Marie. He and ... with six grandchildren. David is also the author of “Shadow and Substance.” , “Love, ...
(Date:3/23/2017)... NC & Seattle, WA (PRWEB) , ... March 23, 2017 , ... ... public health emergency and now estimates that there could be four million Zika-related cases ... growing epidemics to date with numbers of US cases reported per year skyrocketing to ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... their communities, 16 more public health departments have been awarded national accreditation through ... 4.5 million people into the expanding network of communities across the nation whose ...
(Date:3/23/2017)... ... ... The IoT (Internet of Things) is revolutionizing the way the world operates. ... and individual consumers alike. Laboratories can maximize their profit margin by increasing throughput. ... trillion to $11 trillion dollars by the year 2025. McKinsey expects the IoT to ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017  Transportation Insight, a multi-modal ... end-to-end supply chain management firm with expertise serving clients ... Solutions Rick Zaffarano was named a 2017 ... Supply Chain by the only publication exclusively dedicated to ... supply chain. "Rick has brought to Transportation ...
(Date:3/23/2017)... INDIANAPOLIS , March 23, 2017  Eli ... the William Sansum Diabetes Center have established a research ... by diabetes through enhanced research, education and care. ... disease bears a disproportionate weight on Latino families in ... David Kerr , M.D., FRCPE, director of Innovation and ...
(Date:3/23/2017)...  The U.S. Food and Drug Administration today granted ... adults and pediatric patients 12 years and older with ... not received prior chemotherapy. This is the first FDA-approved ... skin cancer. "While skin cancer is one ... form called Merkel cell cancer have not had an ...
Breaking Medicine Technology: