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UNC study: Obese 3-year-olds show early warning signs for future heart disease
Date:3/1/2010

CHAPEL HILL A study by University of North Carolina at Chapel Hill researchers found that obese children as young as 3 years old have elevated levels of C-reactive protein, a marker of inflammation that in adults is considered an early warning sign for possible future heart disease.

In addition, the study found elevated levels of two other inflammatory markers the ratio of ferritin/transferrin saturation (F/T) and the absolute neutrophil count (ANC) in obese children. Elevated F/T levels started at age 6 and elevated ANC levels were found starting at age 9.

"These findings were a surprise to us," said lead author Asheley Cockrell Skinner, Ph.D., an assistant professor of pediatrics in the UNC School of Medicine. "We're seeing a relationship between weight status and elevated inflammatory markers much earlier than we expected."

"Most adults understand that being overweight or obese isn't good for them," Skinner said. "But not as many people realize that it may be unhealthy for young children to be overweight."

It can be very difficult for parents to tell when their child is overweight, Skinner said. "Especially with younger children and smaller children, because they're so short it only takes seven or eight pounds to change them from being a healthy weight to being overweight," she said.

The study was published online March 1 by the journal Pediatrics. Skinner and fellow Department of Pediatrics researchers Eliana Perrin, M.D., M.P.H., Michael Steiner, M.D. and Frederick Henderson, M.D. arrived at these findings after analyzing data collected as part of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006.

Their analysis included data from 16,335 children ages 1-17 years, who were grouped into four categories based on their body mass index (BMI): healthy weight, overweight, obese and very obese. Under this scheme, a 3.5-year-old who is 39 inches tall and weighs 34 po
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Contact: Tom Hughes
tahughes@unch.unc.edu
919-966-6047
University of North Carolina School of Medicine
Source:Eurekalert

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