Navigation Links
UNC shares $6 million Leducq award to study heart failure
Date:9/30/2011

(Embargoed) CHAPEL HILL, N.C. A collaborative network of European and North American scientists, including from the University of North Carolina at Chapel Hill School of Medicine, have been awarded a total of $6 million over five years to explore the biology of heart failure and to find new therapies for it.

The grant was awarded by Fondation Leducq Transatlantic Networks of Excellence Program, headquartered in Paris, France. Fondation Leducq is a French non-profit health research foundation, which is designed to promote collaborative research involving centers in North America and Europe in the areas of cardiovascular and neurovascular disease.

"Proteotoxicity: an unappreciated mechanism of heart disease and its potential for novel therapeutics" is the title of this network's award-winning project. "Proteotoxicity" refers to potential health consequences due to the failure of cells to degrade and clear intracellular aggregated proteins. This may include misshapen or misfolded proteins that could, for instance, disrupt intracellular messages and impede chemical reactions.

"Recent discoveries suggest that the failure to clear aggregated proteins is a major factor in hereditary and acquired cardiac and skeletal muscle diseases," said Network of Excellence Core member, Cam Patterson, MD, MBA, Ernest and Hazel Craige Distinguished Professor of Medicine and cardiology division chief at UNC. "This network is the first to harness the synergy between skeletal and cardiac muscle research in the emerging area of cardiac protein turnover and proteotoxicity by including experts in both fields."

The project's 3 main research aims are to (1) define the role of proteotoxicity in clinically relevant models of heart failure, (2) determine the networks of genes and gene products operating in cardiac muscle cell protein degradation and aggregation, (3) explore novel interventions to reduce and/or block proteotoxicity in animal models of cardiomyopathy and heart failure.

Sharing the new award with Patterson at UNC are network members Jeff Robbins, PhD at Cincinnati Children's Hospital in Ohio; Mathias Gautel, MD, PhD at King's College in London, England; Lucie Carrier, PhD, at the University Medical Center Hamburg-Eppendorf, in Hamburg, Germany; Marco Sandri, MD, PhD at the Venetian Institute of Molecular Medicine and University of Padova, Padova, Italy; and Joseph A. Hill, MD, PhD at the University of Texas Southwestern Medical Center, Dallas, Texas.

Since 2004 when grants were first awarded under the Transatlantic Networks of Excellence in Cardiovascular Research Program, 31 collaborative networks have been selected for Leducq support, representing more than 300 investigators at 115 institutions in 17 countries, with research interests spanning from heart failure to cerebral hemorrhage.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. Internationally acclaimed immunologist shares $1 million Shaw Prize
2. Expert Shares Spring Break Safety Tips
3. John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques
4. Child soldier trauma in Uganda shares similarities with Northern Ireland
5. Self-Published Author Shares Her Personal Story of Hope Amidst Despair
6. Retirement Options Shares Tips for Retiring Happy Regardless of Income
7. Webinar Shares Proven Social Media Approach to BtoB Lead Generation
8. Micromet Announces Pricing of Public Offering of 10 Million Shares of Common Stock
9. Cincinnati Childrens earns $12 million NIH grant to test migraine prevention medicines
10. Scripps research scientist wins $3.6 million NIH Method to Extend Research in Time award to study alcoholism in Native Americans
11. Wayne State researcher developing treatments for Parkinsons with aid of $2.15 million NIH grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC shares $6 million Leducq award to study heart failure
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: