Navigation Links
UNC shares $6 million Leducq award to study heart failure

(Embargoed) CHAPEL HILL, N.C. A collaborative network of European and North American scientists, including from the University of North Carolina at Chapel Hill School of Medicine, have been awarded a total of $6 million over five years to explore the biology of heart failure and to find new therapies for it.

The grant was awarded by Fondation Leducq Transatlantic Networks of Excellence Program, headquartered in Paris, France. Fondation Leducq is a French non-profit health research foundation, which is designed to promote collaborative research involving centers in North America and Europe in the areas of cardiovascular and neurovascular disease.

"Proteotoxicity: an unappreciated mechanism of heart disease and its potential for novel therapeutics" is the title of this network's award-winning project. "Proteotoxicity" refers to potential health consequences due to the failure of cells to degrade and clear intracellular aggregated proteins. This may include misshapen or misfolded proteins that could, for instance, disrupt intracellular messages and impede chemical reactions.

"Recent discoveries suggest that the failure to clear aggregated proteins is a major factor in hereditary and acquired cardiac and skeletal muscle diseases," said Network of Excellence Core member, Cam Patterson, MD, MBA, Ernest and Hazel Craige Distinguished Professor of Medicine and cardiology division chief at UNC. "This network is the first to harness the synergy between skeletal and cardiac muscle research in the emerging area of cardiac protein turnover and proteotoxicity by including experts in both fields."

The project's 3 main research aims are to (1) define the role of proteotoxicity in clinically relevant models of heart failure, (2) determine the networks of genes and gene products operating in cardiac muscle cell protein degradation and aggregation, (3) explore novel interventions to reduce and/or block proteotoxicity in animal models of cardiomyopathy and heart failure.

Sharing the new award with Patterson at UNC are network members Jeff Robbins, PhD at Cincinnati Children's Hospital in Ohio; Mathias Gautel, MD, PhD at King's College in London, England; Lucie Carrier, PhD, at the University Medical Center Hamburg-Eppendorf, in Hamburg, Germany; Marco Sandri, MD, PhD at the Venetian Institute of Molecular Medicine and University of Padova, Padova, Italy; and Joseph A. Hill, MD, PhD at the University of Texas Southwestern Medical Center, Dallas, Texas.

Since 2004 when grants were first awarded under the Transatlantic Networks of Excellence in Cardiovascular Research Program, 31 collaborative networks have been selected for Leducq support, representing more than 300 investigators at 115 institutions in 17 countries, with research interests spanning from heart failure to cerebral hemorrhage.


Contact: Les Lang
University of North Carolina School of Medicine

Related medicine news :

1. Internationally acclaimed immunologist shares $1 million Shaw Prize
2. Expert Shares Spring Break Safety Tips
3. John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques
4. Child soldier trauma in Uganda shares similarities with Northern Ireland
5. Self-Published Author Shares Her Personal Story of Hope Amidst Despair
6. Retirement Options Shares Tips for Retiring Happy Regardless of Income
7. Webinar Shares Proven Social Media Approach to BtoB Lead Generation
8. Micromet Announces Pricing of Public Offering of 10 Million Shares of Common Stock
9. Cincinnati Childrens earns $12 million NIH grant to test migraine prevention medicines
10. Scripps research scientist wins $3.6 million NIH Method to Extend Research in Time award to study alcoholism in Native Americans
11. Wayne State researcher developing treatments for Parkinsons with aid of $2.15 million NIH grant
Post Your Comments:
Related Image:
UNC shares $6 million Leducq award to study heart failure
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... Sandra ... ... Astellas is a pharmaceutical company ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
(Date:6/23/2016)... 2016 The Biotechnology industry might ... present great opportunities to investors. assesses the recent ... (NYSE: XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... receive your complimentary trade alerts at: ...
Breaking Medicine Technology: