Navigation Links
UNC scientists identify growth factor as possible cancer drug target
Date:6/9/2009

CHAPEL HILL, N.C. - To grow and spread, tumors need new blood vessels, a process called angiogenesis. One growth factor that causes angiogenesis has been identified - vascular endothelial growth factor or VEGF - and drugs to inhibit VEGF are already in use. But not all tumors respond to the therapy initially or over the long term. Thus new growth factors need to be identified to aid in developing the next generation of angiogenesis inhibitors.

Scientists at the UNC Lineberger Comprehensive Cancer Center report finding a new angiogenesis protein, SFRP2, found in the blood vessels of numerous tumor sites, including breast prostate, lung, pancreas, ovarian, colon, kidney tumors, and angiosarcomas. The scientists found that SFRP2 is a potent stimulator of angiogenesis. This protein may be a favorable target for inhibiting angiogenesis which would then "starve" the tumor of its blood supply, thus destroying the cancer.

"The discovery that SFRP2 stimulates angiogenesis and is present in blood vessels of a wide variety of tumors provides us with a new target for drug design," said Nancy Klauber-DeMore, M.D., senior author. The study was published online in the journal Cancer Research. Klauber-DeMore is associate professor of surgery and a member of UNC Lineberger Comprehensive Cancer Center.

Based on the UNC-led team's understanding of how this protein works in the blood vessels, scientists successfully utilized a drug, tacrolimus, which is commonly used to prevent organ transplant rejection, to inhibit the growth of angiosarcoma in pre-clinical studies. Angiosarcoma is a highly aggressive cancer that begins in the cells lining the blood or lymph vessels for which options for therapy are limited.


'/>"/>

Contact: Dianne Shaw
dgs@med.unc.edu
919-966-5905
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 30, 2014 A group of Americans is ... an epidemic that, left unchecked, could create a catastrophic, global ... headed to Africa. John Rogers, the Executive Director the Eugene ... to fight a disease most think mankind conquered long ago: ... years ago is on the comeback in several countries - ...
(Date:9/30/2014)... 2014 Two revolutionary procedures now being utilized ... gum disease a far less painful and far more ... you’ve ever felt electric shock waves surge through your teeth ... beverage, it’s possible you already know the impact of receding ... general dentist in West Palm Beach, and a Fellow in ...
(Date:9/30/2014)... (HealthDay News) -- Medicare should cover low-dose computed tomography ... the disease, a coalition of more than 60 patient ... the Lung Cancer Alliance, the Society of Thoracic Surgeons, ... and the American Society of Clinical Oncology, made its ... Centers for Medicare & Medicaid Services (CMS). Such ...
(Date:9/30/2014)... Defense has made progress in reducing the stigma associated ... and post-traumatic stress disorder, but more improvement is still ... Despite efforts of both the Defense Department and the ... service members still do not seek needed care for ... concerted effort to promote treatment as a way to ...
(Date:9/30/2014)... that causes a rare premature aging disease could lead ... unstoppable cell division that makes cancer so deadly. ... U-M Health System recently discovered a protein mutation that ... hematopoietic stem cells can,t regenerate and make new blood. ... cancer and bone marrow failure. , But the ...
Breaking Medicine News(10 mins):Health News:US Delegation Heads to North Korea to Combat Tuberculosis Epidemic 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 3Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2Health News:US military making progress reducing stigma tied to seeking help for mental illness 2Health News:US military making progress reducing stigma tied to seeking help for mental illness 3Health News:Disease decoded: Gene mutation may lead to development of new cancer drugs 2
... Nutrition Month(R), and Cabot Creamery Cooperative(R) offers, ... they age, CABOT, Vt., Feb. 19 March ... Dietetic Association,s campaign to promote,the importance of eating a ... to eat better, smarter and,healthier. Research by the US ...
... Harvard-Trained Cosmetic and Laser,Surgeon and Board Certified ... Relations to spearhead her PR campaign. Dr. Jacob,Director ... performs a variety of medical procedures and services, ... A veteran in the field, Dr. Jacob works ...
... Hyperactivity Disorder in ... Throughout Asia -, NEW HAVEN, Conn. and KORTRIJK, ... specialty pharmaceuticals company,focused on bringing proprietary medicines to the ... announced that RHEI has,licensed from MethaPharma the exclusive right ...
... Feb. 18 The following was,released today by ... Ambulance diversion? Crowded,emergency departments? Reports and articles over ... longer emergency department wait times (in,excess of 12 ... than one,third of area hospitals were to divert ...
... An international team of scientists led by a University ... into the realm of consciousness. , The scientists have ... perception, by showing how single neurons in the human ... of Leicester bioengineer Dr Rodrigo Quian Quiroga is spearheading ...
... atrial fibrillation, analysis shows , , MONDAY, Feb. 18 (HealthDay ... that are prescribed to lower cholesterol levels may also ... that boosts the odds of a stroke, French researchers ... more than 3,500 participants showed that those patients who ...
Cached Medicine News:Health News:Hey Boomers, Here's to Your Health! 2Health News:Hey Boomers, Here's to Your Health! 3Health News:Hey Boomers, Here's to Your Health! 4Health News:Hey Boomers, Here's to Your Health! 5Health News:Dr. Carolyn Jacob Hires Empower Public Relations 2Health News:RHEI Pharmaceuticals Licenses Attental From MethaPharma (Vemedia Group) for Distribution Throughout Asia 2Health News:RHEI Pharmaceuticals Licenses Attental From MethaPharma (Vemedia Group) for Distribution Throughout Asia 3Health News:Gilbert Hospital Turns the Tables on the Flu 2Health News:Scientists explore consciousness 2Health News:Scientists explore consciousness 3Health News:Cholesterol-Lowering Drugs May Ease Irregular Heartbeat 2Health News:Cholesterol-Lowering Drugs May Ease Irregular Heartbeat 3
(Date:9/30/2014)... , Sept. 30, 2014   Easy Breathe , ... , today announced that it now offers the revolutionary ... CPAPs are the first sleep apnea therapy devices with ... and easy to track and share real-time data on ... of their CPAP therapy.  In addition, the internal modem ...
(Date:9/30/2014)... Sept. 30, 2014 Valeant Pharmaceuticals International, Inc. ... announced that the company,s Bridgewater, New Jersey ... U.S. Food and Drug Administration (FDA) relating to an ... regards to Sculptra Aesthetic injectable, which was divested to ... the management of Valeant,s contract manufacturers (rather than Valeant,s ...
(Date:9/30/2014)... 2014 BioStructures, LLC has been awarded ... Tissue Banks (AATB), it was announced today by ... Accreditation follows an intensive nine-month process, including ... inspector.  It establishes that the level of medical, ... or exceeds the standards set by the AATB.  ...
Breaking Medicine Technology:Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 2Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 4Valeant Pharmaceuticals' Bridgewater Location Receives Warning Letter From FDA 2Biostructures, LLC Earns AATB Accreditation 2
... Patients For Over a Decade, SAN FRANCISCO, ... benefit from arthroscopic surgery long term,according to a ... for Sports Medicine Specialty Day at The Moscone ... surgery, rather than conservative,methods, yielded excellent results., ...
... LARGO, Fla., March 7 AlphaMed Pharmaceuticals,Corporation announced ... version of the therapeutic protein alpha 1-antitrypsin (AAT).,AlphaMed ... production system in yeast. The yeast has been ... that which is,manufactured by the human body., ...
Cached Medicine Technology:Controversial Shoulder Surgery for First-time Dislocation Proven Effective Long-Term 2Controversial Shoulder Surgery for First-time Dislocation Proven Effective Long-Term 3AlphaMed Pharmaceuticals Announces Breakthrough in the Development of Recombinant Alpha 1-Antitrypsin 2
... spinal procedures. The SpineAssist platform for enhancing ... solution that enables surgery to be performed ... currently answers a growing need for accurate ... pedicle screw insertion for spine fusion procedures. ...
ACRYSOF®, Posterior Chamber Intraocular Lenses are indicated for the replacement of the human lens to achieve visual correction of aphakia in patients sixty years and older. These lenses are i...
Single piece PMMA lens, AC depth: 4.7....
Single-Piece PMMA IOLs for the replacement of the human crystalline lens in the visual correction of aphakia....
Medicine Products: