Navigation Links
UNC scientists identify growth factor as possible cancer drug target
Date:6/9/2009

CHAPEL HILL, N.C. - To grow and spread, tumors need new blood vessels, a process called angiogenesis. One growth factor that causes angiogenesis has been identified - vascular endothelial growth factor or VEGF - and drugs to inhibit VEGF are already in use. But not all tumors respond to the therapy initially or over the long term. Thus new growth factors need to be identified to aid in developing the next generation of angiogenesis inhibitors.

Scientists at the UNC Lineberger Comprehensive Cancer Center report finding a new angiogenesis protein, SFRP2, found in the blood vessels of numerous tumor sites, including breast prostate, lung, pancreas, ovarian, colon, kidney tumors, and angiosarcomas. The scientists found that SFRP2 is a potent stimulator of angiogenesis. This protein may be a favorable target for inhibiting angiogenesis which would then "starve" the tumor of its blood supply, thus destroying the cancer.

"The discovery that SFRP2 stimulates angiogenesis and is present in blood vessels of a wide variety of tumors provides us with a new target for drug design," said Nancy Klauber-DeMore, M.D., senior author. The study was published online in the journal Cancer Research. Klauber-DeMore is associate professor of surgery and a member of UNC Lineberger Comprehensive Cancer Center.

Based on the UNC-led team's understanding of how this protein works in the blood vessels, scientists successfully utilized a drug, tacrolimus, which is commonly used to prevent organ transplant rejection, to inhibit the growth of angiosarcoma in pre-clinical studies. Angiosarcoma is a highly aggressive cancer that begins in the cells lining the blood or lymph vessels for which options for therapy are limited.


'/>"/>

Contact: Dianne Shaw
dgs@med.unc.edu
919-966-5905
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... released a new blog post explaining the main features of ... Auto insurance quotes help many drivers find the best coverage ... an agent or visit an agency for price information. These ... http://autocarinsurancebest.com/ . , Every business who relies heavily on transportation ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 Joan ... and keynote speaker at the upcoming 32nd Annual ... ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , shares ... would have gone undetected if she had not followed ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
(Date:1/22/2015)... 22, 2015 Payday lending practices in ... and cause financial distress to the states that permit ... Howard University’s Center on Race and Wealth. , While ... activity, payday loans at the same time substantially depress ...
(Date:1/22/2015)... 2015 JJsHouse.com is a famous dress online ... business announces its latest collection of wedding dresses , ... important issue is the wedding dress on your big day; ... woman’s life. Every bride wants to find the most suitable ...
Breaking Medicine News(10 mins):Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... The most common indication worldwide for pediatric transplantation, biliary ... liver disease in newborns. Recently, Childrens Hospital of Pittsburgh ... children with biliary atresia face that lead to the ... of children undergoing their first liver transplant are diagnosed ...
... Washington University School of Medicine in St. Louis have ... proteins associated with the formation of actin networks, which ... to move is important to a broad range of ... disease-causing invaders and how metastasizing cancer cells migrate from ...
... What: , The AACR Annual Meeting features the ... cancer research. This years meeting focuses on ... pipeline, clinical trials, and new approaches to cancer ... of the meeting, the program schedule and related ...
... Workout ... Jude Children,s Research ... Hospital(R), FORT LAUDERDALE, Fla., Jan. 8 ... Ab Crunch Challenge,a fitness challenge that will benefit your waistline and is expected ...
... Pa., Jan. 8 Isolagen(TM), Inc. (Amex: ILE ... Declan Daly,Chief Executive Officer of Isolagen, will present at ... 2008 at 2:00 p.m.,(Pacific Time) / 11:00 a.m. (Eastern ... Francis Hotel in San Francisco, California., The presentation ...
... Top Five New York State Hospitals, ... (OTC Bulletin Board: GLOB), an international e-Health, ... Wyndgate,Technologies(R) division has signed a purchase agreement ... New York for its,advanced transfusion management software, ...
Cached Medicine News:Health News:Children's Hospital physicians publish review of transplant issues in patients with biliary atresia 2Health News:Insights into cell movement likely to aid immune study, cancer research 2Health News:Insights into cell movement likely to aid immune study, cancer research 3Health News:Get a Six Pack While Giving Back 2Health News:Get a Six Pack While Giving Back 3Health News:Isolagen Inc. to Present at the 26th Annual JPMorgan Healthcare Conference 2Health News:Global Med Technologies(R) Adds Eighth SafeTrace Tx(R) Client in New York State 2Health News:Global Med Technologies(R) Adds Eighth SafeTrace Tx(R) Client in New York State 3
(Date:1/22/2015)... 2015  ViewRay™, a privately held medical device company, announced ... agreement with ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) ... treatment of cancer in Japan . ... first and only MRI-guided radiation therapy system that images ...
(Date:1/22/2015)... /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), ... for cardiovascular disease and overall health is pleased to provide ... and its outlook for 2015 from the CEO, Mr. ... We would like to take this opportunity to share with ...
(Date:1/22/2015)... 2015 Increasing sophistication among enterprise buyers of language ... in 2015, says Moravia CMO, Renato ... by market research firm Common Sense Advisory, 15 percent ... translation and localization needs. "From a language industry perspective, ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
New - Color Coded Berman Airways. A simple idea makes size identification easier for you., ,Premium upgrade without a premium price. Color Coded Berman airways are latex-free., ,Plastic. Single use...
... Fome-Cuf® Oral/Nasal Wire Reinforced Endotracheal ... kit is packaged individually and includes ... Maintenance Device (CMD™), and 15 mm ... provides maximum patient safety by helping ...
... Portex® Blue Line® uncuffed ... Magill or Murphy styles, in ... ,Blue Line® adult and pediatric ... from implant-tested polyvinyl chloride with ...
... Ruschelit® PVC. 2 eyes, oral. Marked ... age. X-ray opaque line. Graduated. Single ... Designed to reduce kinking of the ... Thermosensitive Ruschelit® PVC adapts to the ...
Medicine Products: