Navigation Links
UNC scientists discover potential strategy to improve cancer vaccines
Date:12/14/2010

CHAPEL HILL, N.C. The promise of vaccines targeted against various types of cancer has raised the hopes of patients and their families. The reality, however, is that these promising treatments are difficult to develop. One of the challenges is identifying a discrete cellular target to stop cancer growth without inactivating the immune system. Scientists at UNC Lineberger Comprehensive Cancer Center report a laboratory finding that has the potential to increase the effectiveness of therapeutic cancer vaccines.

The team found that the absence of the function of a protein called NLRP3 can result in a four-fold increase in a tumor's response to a therapeutic cancer vaccine. If this finding proves consistent, it may be a key to making cancer vaccines a realistic treatment option. Their findings were published in the Dec. 15, 2010 issue of the journal Cancer Research.

Jonathan Serody, MD, a study author, explains, "This finding suggests an unexpected role for NLRP3 in vaccine development and gives us a potentially pharmacologic target to increase vaccine efficacy."

The research team was headed by co-leaders of the UNC Lineberger Immunology Program: Serody, MD, an expert in tumor immunology, and Jenny Ting, PhD, a pioneer in understanding the NLR family of proteins. Serody is the Elizabeth Thomas Professor of Hematology and Oncology. Ting is UNC Alumni Distinguished Professor of Microbiology and Immunology and director of the Inflammation Center at UNC.

The team discovered that deleting the NLRP3 proteins reduced the supply of a tumor-associated cell called myeloid-derived suppressors, making them five times less effective in reaching the site of tumor growth. Researchers working with Serody had previously shown that these myeloid cells are critically important as they allow the tumor to evade a beneficial immune response. This finding is the first to link immature myeloid cells, NLRP3, and the response to cancer vaccines.<
'/>"/>

Contact: Dianne Shaw
dgs@med.unc.edu
919-966-5905
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... By Steven Reinberg ... -- Simple blood tests may one day help predict survival ... lateral sclerosis (ALS), also called Lou Gehrig,s disease, Italian researchers ... yield clues to how fast ALS is progressing are called ... kidney and liver health, according to the U.S. National Library ...
(Date:7/22/2014)... (Boston)-- Researchers from Boston University School of Medicine ... that participants who received care through BMC,s Violence ... physical, mental, emotional and social needs of violently ... injuries and experienced life changing behaviors through connections ... feel trust and hope. These findings are reported ...
(Date:7/22/2014)... European Bio stimulants Market report defines and segments the ... of revenue. The bio stimulants market in Europe is ... to $940.6 million by 2018, at a CAGR of ... TOC of the Europe Bio stimulants Market report, to ... http://www.micromarketmonitor.com/market/europe-bio-stimulants-1315565884.html , Agriculture contributes to 10% of ...
(Date:7/22/2014)... In a special day of pampering ... School of Beauty joined forces with The Discovery ... a free “Make-over Day.” In a win-win event, Marinello ... the community, and The Discovery House clients had a ... some first-hand experience about career possibilities. , “The ...
(Date:7/22/2014)... 22, 2014 Expert Publishing ... Services , announces the launch of PoisonEXPERT™ ... and safety professionals employed by organizations that use ... to manage the impact of chemicals on their ... to relevant chemical-specific information and medical protocols that ...
Breaking Medicine News(10 mins):Health News:Blood Test Might Help Predict Survival With Lou Gehrig's Disease 2Health News:Blood Test Might Help Predict Survival With Lou Gehrig's Disease 3Health News:Clients of BMC's violence interventional advocacy program find experience supportive 2Health News:Clients of BMC's violence interventional advocacy program find experience supportive 3Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 5Health News:The Discovery House 'Make-over Day' Adds Pampering To Recovery 2Health News:The Discovery House 'Make-over Day' Adds Pampering To Recovery 3Health News:PoisonEXPERT™ from ExPub Now Available 2Health News:PoisonEXPERT™ from ExPub Now Available 3
... turning their backs on tanning amid growing concerns over skin ... survey shows that teenagers are resisting the urge to tan ... 5,073 Australian adults and 699 Australian teenagers aged 12 to ... that 68 % of those aged 12-17 said they had ...
... University have found a new model that shows how ... in the presence of microenvironment of tumor cells. // ... skin cell to malignant cell is understood with the ... offer new insights into the influence of the tumor ...
... the developing fetus, a womb confers safety and security to ... a womb is even necessary for normal brain development. // ... found to have a poor brain development when compared to ... done regarding brain development of babies born around 26 weeks ...
... bottle-feeding may impose an increased risk of iron deficiency ... American children) according to // a new study by ... Wisconsin. , ,"This is the first study that ... prolonged bottle-feeding and iron deficiency, among a nationally representative ...
... in the UK has revealed that smokers are unconcerned with ... particular they seemed to be aware of the damage // ... lip and even the teeth, but were strangely reluctant to ... oral and maxillofacial surgeons, who are launching a massive awareness ...
... across the walls of a patient's room have been ... hypertension and rheumatic complaints, a study says.//,A study group ... kept in medicated rooms were cured in shorter less ... study involved 36 patients, of whom 19 were kept ...
Cached Medicine News:Health News:Aussie teens applauded for declining sun tan 2Health News:New Model for understanding Tumor Metastasis 2Health News:Brain development compromised in premature babies 2Health News:Iron deficiency found in children with prolonged bottle feeding 2Health News:Now medicated coir to cure ailments 2
(Date:7/22/2014)... -- Research and Markets  has announced the addition ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... monitor, and assess medical conditions, diseases, or infections usually ... earlier and more targeted treatment. These tests are minimally ... This kind of diagnostics provides early detection of diseases ...
(Date:7/22/2014)... , July 22, 2014 BiologicTx ® ... first 3-way Kidney Paired Donation transplant exchange ... procedures happened on July 9 at the Miami Transplant ... Miami, Fla. Kidney Paired ... are not compatible for kidney transplant with one another ...
(Date:7/22/2014)... , July 22, 2014  A central ... a SynCardia temporary Total Artificial Heart ... Strong Memorial Hospital with the Freedom® portable driver ... Fontana, a 64-year-old retiree from a Syracuse ... He managed the condition with medications, an implantable ...
Breaking Medicine Technology:Global IVD Market 2014-2018: Key Vendors are Abbott Laboratories, Johnson & Johnson, Roche Diagnostics and Siemens Healthcare 2Global IVD Market 2014-2018: Key Vendors are Abbott Laboratories, Johnson & Johnson, Roche Diagnostics and Siemens Healthcare 3BiologicTx Paired Donation Aids In Successful Kidney Transplants 2BiologicTx Paired Donation Aids In Successful Kidney Transplants 3'I'm a Heartless SOB' Jokes Patient Discharged from Strong Memorial Hospital without a Human Heart 2'I'm a Heartless SOB' Jokes Patient Discharged from Strong Memorial Hospital without a Human Heart 3
... Calif., Feb. 24, 2011 Codexis, Inc. (Nasdaq: ... promoted to Chief Technology Officer and Senior Vice President, Process ... report to Alan Shaw, Ph.D., President and Chief Executive Officer. ... a 25-year career with DuPont. He served as Vice President, ...
... Par Pharmaceutical Companies, Inc. (NYSE: PRX ) ... ended December 31, 2010. For the fourth quarter ... $227 million and income from continuing operations of $17.6 million, ... million charge related to the settlement of litigation and changes ...
Cached Medicine Technology:Codexis Names David Anton CTO & SVP, Process Development & Manufacturing 2Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 2Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 3Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 4Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 5Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 6Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 7Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 8Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 9Par Pharmaceutical Companies Reports Fourth Quarter and Full-Year Results for 2010 10
Agarose L03 is recommended for separations of DNA fragments = 1,000 bp....
... Anion traces: chloride (Cl) ≤ 5000 mg/kg sulfate (SO ... 50 mg/kg Cd ≤ 5 mg/kg Co ≤ 5 ... Fe ≤ 10 mg/kg K ≤ 50 mg/kg Mg ... 2000 mg/kg Ni ≤ 5 mg/kg Pb ≤ 5 ...
... ≤ 5000 mg/kg sulfate (SO 4 ) ≤ 5000 ... 5 mg/kg Co ≤ 5 mg/kg Cr ≤ 5 ... K ≤ 50 mg/kg Mg ≤ 5 mg/kg Mn ... 5 mg/kg Pb ≤ 5 mg/kg Zn ≤ 5 ...
... flexible gels for separation of ... of wide range and standard ... mg/mL, clear, faintly yellow, hot ... MP: 90 °C (1% in ...
Medicine Products: