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UNC researchers use luminescent mice to track cancer and aging in real-time
Date:1/17/2013

ggests that activation of senescence results from an abnormal milieu within a developing cancer. Somehow, many or all the cells in a would-be tumor know they are in a bad place, and activate this tumor suppressor gene as a defense mechanism, even if they are not the would-be cancer cells themselves. This occurs really early in the cancer; we're talking about the earliest events of neoplasia that have ever been measured in living animals," said Sharpless.

The Sharpless group believes similar approaches to monitoring senescence can be developed in order to study aging and tumor development in humans. The group is particularly interested in how cancer therapies influence human aging and patient outcome. Working with UNC oncologists, the Sharpless group has already measured p16 expression in several hundred patients undergoing cancer therapy. These studies, along with efforts employing the glowing mouse, aims to develop more effective and tolerable patient treatment schemes based upon 'molecular', as opposed to 'chronologic', age.


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Contact: William Davis
william_davis@med.unc.edu
919-966-5906
University of North Carolina Health Care
Source:Eurekalert  

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