Navigation Links
UNC researchers identify seventh and eighth bases of DNA
Date:7/21/2011

(Embargoed) CHAPEL HILL For decades, scientists have known that DNA consists of four basic units -- adenine, guanine, thymine and cytosine. Those four bases have been taught in science textbooks and have formed the basis of the growing knowledge regarding how genes code for life. Yet in recent history, scientists have expanded that list from four to six.

Now, with a finding published online in the July 21, 2011, issue of the journal Science, researchers from the UNC School of Medicine have discovered the seventh and eighth bases of DNA.

These last two bases called 5-formylcytosine and 5 carboxylcytosine are actually versions of cytosine that have been modified by Tet proteins, molecular entities thought to play a role in DNA demethylation and stem cell reprogramming.

Thus, the discovery could advance stem cell research by giving a glimpse into the DNA changes such as the removal of chemical groups through demethylation that could reprogram adult cells to make them act like stem cells.

"Before we can grasp the magnitude of this discovery, we have to figure out the function of these new bases," said senior study author Yi Zhang, Ph.D., Kenan Distinguished Professor of biochemistry and biophysics at UNC and an Investigator of the Howard Hughes Medical Institute. "Because these bases represent an intermediate state in the demethylation process, they could be important for cell fate reprogramming and cancer, both of which involve DNA demethylation."

Much is known about the "fifth base," 5-methylcytosine, which arises when a chemical tag or methyl group is tacked onto a cytosine. This methylation is associated with gene silencing, as it causes the DNA's double helix to fold even tighter upon itself.

Last year, Zhang's group reported that Tet proteins can convert 5 methylC (the fifth base) to 5 hydroxymethylC (the sixth base) in the first of a four step reaction leading back to bare-boned cy
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC researchers identify seventh and eighth bases of DNA
(Date:2/27/2015)... 2015 The Hermitage has responded to ... violations that date back to 2012. The mitigation work ... soon as it was approved in the summer of ... the allegations we agreed to 100% mitigation at our ... Holding Company. , Barnes further added, "we were surprised ...
(Date:2/27/2015)... UAS LifeSciences, will showcase their new chewable adult ... March 6 to 8 in Anaheim, CA. ... down best tasting probiotic in the business, Adult Cubes. ... Vitamin C. This is a companion product to our ... Living’s Supplement Award and Taste for Life’s Essential Supplements ...
(Date:2/27/2015)... Park, Kansas (PRWEB) February 27, 2015 ... ( http://www.cdc.gov/datastatistics/2008/brainInjuries ), more than 38 million children ... States each year. As a result of ... reaching capacity maximizing their equipment and square footage ... suspended athletic equipment. , "Athletic ...
(Date:2/27/2015)... 2015 Leading up to the White ... PartnerTech Inc. President, Gary Bruce, joined with other ... for the TechAmerica DC Fly-In. This is a ... technology along with the opportunity to have a voice ... products, evidenced by their current projects with NanoLumens ...
(Date:2/27/2015)... Javon Bea Mercy Health System President ... and open to the public, is held the second ... Mall Food Court, 2500 Milton Ave. Monthly meetings include ... and an educational health-related presentation. Participants receive a free ... for Health. , March 10: Using exercise to feel ...
Breaking Medicine News(10 mins):Health News:Southern Vermont's Hermitage Club Announces Statement Regarding Vermont Attorney General Lawsuit for Permit Violations 2Health News:UAS LifeSciences to Launch UP4 Adult Cubes at Expo West 2Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 2Health News:Rise of Students Participating in Sports Creates Need for Preventative Maintenance to Gymnasium Equipment in Athletic Facilities 3Health News:PartnerTech Joins Technology Association of Georgia for TechAmerica DC Fly-In 2Health News:PartnerTech Joins Technology Association of Georgia for TechAmerica DC Fly-In 3
... is good for the heart. A recent study undertaken by Robert// ... School has found that by eating fish regularly, the risk ... a lower risk of cardiovascular problems. , ,The substance ... lean varieties such as salmon. The study used more than 3,000 ...
... A large new study reports that Vitamin E is unlikely ... the risk of heart attacks and stroke in older women. ... Pauling Institute at Oregon State University and an expert on ... to reduce the risk of heart and other serious degenerative ...
... age of 60 and above can have less back pain ... back supporting device and doing some special exercises. ,In ... said that the new specially weighed back support device can ... extensive improvements in strength for the women who had suffered ...
... Prayers can help heart patients in the recovery process ... // University Medical Centre. Researchers said cardiac patients using ... heart failure, post-procedural ischemia or heart attack,than those without ... to April 1998 with symptoms of acute coronary ischemia. ...
... and colleagues compared their Cell culture small pox vaccine// ... vaccine. Small pox vaccine currently used is a live, ... produces adverse effects in vaccinated, 15-42 develop serious or ... 2 people every million die because of this vaccine. ...
... of osteoporosis is useful, but changes in bone// mineral ... are anti-resorptive agents that prevent bone breakdown. ,For ... that enhances bone formation is preferable, and this is ... (PTH). However, the use of PTH is limited by ...
Cached Medicine News:Health News:The Benefits of Strontium in the treatment for Osteoporosis Questioned 2
(Date:2/26/2015)... , Feb. 26, 2015  MEI Pharma, Inc. (Nasdaq: ... development of novel therapies for cancer, announced today that ... will present at the Cowen and Company 35 th ... 10:40 a.m. Eastern time from the Boston Marriott Copley Place. ... www.meipharma.com . A replay will be available approximately one ...
(Date:2/26/2015)... , Feb. 26, 2015 Ultrasound ... at the Clearwater Beach Hilton to provide the ... to plant reliability professionals from around the world. ... stellar collection of leaders in the field of ... demand for excellence continues with this year,s conference. ...
(Date:2/26/2015)... , Feb. 26, 2015   Coverall North ... franchised businesses, today celebrates 30 Years of Clean, a ... anniversary. Coverall started in 1985 as a ... and is now a leading global brand ... Coverall,s passion and mission have remained consistent: To promote ...
Breaking Medicine Technology:MEI Pharma to Present at Cowen and Company Health Care Conference 2MEI Pharma to Present at Cowen and Company Health Care Conference 3UE Systems Renowned "Ultrasound World" Conference Celebrates its 11th Year 2Coverall Celebrates 30 Years of Clean 2Coverall Celebrates 30 Years of Clean 3
... response roller-pumps, the REVOLUTION provides continuous ... field. Furthermore the dual pump system ... intra-articular pressure and flow rate. , ... controls, providing the surgeon with the ...
... Burner captures still images and full ... archives allows for multiple cases to ... unit provides software burned to every ... and editing. Compatible with DICOM and ...
The Sony DSR20-MD Grade Digital Video Player/Recorder represents a giant leap in digital technology. , ,This equipment is intended to be used by physicians who teach or present medical techniques...
Colour video monitors....
Medicine Products: