Navigation Links
UNC researchers discover 'master regulator' role for little-known protein in cancer cells
Date:4/29/2014

function was less understood at that time.

Choudhury and colleagues designed a series of experiments to find that DAZAP1 binds to a number of other proteins in the cell nucleus and promotes alternative splicing. By studying the cascade of intracellular interactions stemming from DAZAP1's splicing function, Choudhury and colleagues determined that DAZAP1 was associated with the regulation of many genes that are involved in the creation of DNA, the synthesis of RNA, and the proliferation of cells all of which are vital for cancer cells to proliferate and spread. More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway a key signaling pathway that controls cell proliferation.

"Why this protein is found in cancer cells is still a mystery," Choudhury said. "But we now know that when DAZAP1 is overexpressed, the growth of cancer cells slows down significantly. We need to learn much more, but further research could lead to a drugable target."


'/>"/>

Contact: Mark Derewicz
mark.derewicz@unch.unc.edu
919-923-0959
University of North Carolina Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. CWRU researchers profile womens employment, caregiving workloads, effort and health
2. Drug monitoring information improves regimen adherence, Carnegie Mellon researchers say
3. Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function
4. Indiana University researchers gauge the toll of trampoline fractures on children
5. AGA showcases its commitment to improving the pipeline of minority researchers
6. Researchers identify potential new strategy to treat ovarian cancer
7. NYU Steinhardt researchers to study why male millennials risk HIV transmission
8. Researchers generate immunity against tumor vessel protein
9. Researchers at LSTM part of the international team to sequence the tsetse genome
10. Oxygen diminishes the hearts ability to regenerate, researchers discover
11. Finnish team of researchers finds a mutation in a tumor of the jaw
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... Recently, SweetDressy.com, a well-known dress supplier and leader ... 2014 Evening Dresses. All these fresh items are offered ... manager, the special offer is valid until Dec. 20, ... has been working well in the fashion industry for ... Their new dresses may be the best products for ...
(Date:11/24/2014)... Mental health issues affect tens of ... families, ruin careers, and generally destroy lives. , ... suffer,” says Hardy Nutritionals® founder David ... specialized nutritional treatments can reverse these disorders naturally.” ... Matter”, the premiere episode of O2 Media’s new ...
(Date:11/24/2014)... CO, and Philadelphia, PA (PRWEB) November 24, 2014 ... provider of care coordination and disease management services ... has chosen to implement Essette’s Medical Management software ... new Essette SaaS platform in a program to ... Essette suite includes Population Health Management, Care Management, ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 "My friend ... was trying to cross the street in his motorized ... never saw him. I came up with this idea ... at night." , He developed the Safety Lites to ... in low-lighting conditions. The device ensures that motorists can ...
(Date:11/23/2014)... the coming special Friday, Tidebuy, a famous wedding dress ... many products, especially the beautiful colored wedding dresses ( ... amazing discounts, up to 90% off. Don’t hesitate to ... to buy colored wedding dresses in different sizes and ... for delicate craftsmanship, elegant style and perfect lines. All ...
Breaking Medicine News(10 mins):Health News:SweetDressy.com Unveiled A New Selection Of Evening Dresses 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3Health News:ReAdmission Solutions, LLC Selects Essette 2Health News:Beautiful Wedding Dresses Available at Popular B2C Company Tidebuy 2
... U.S. have continued to be mild, officials said , , ... Organization on Wednesday raised the swine flu epidemic level ... imminent, and urged countries to implement their pandemic plans. ... officials that the outbreak could trigger large numbers of ...
... Ohio Residents Access to Nursing Home, Assisted Living, Home Care ... Code StatewideRICHMOND, Va., April 30 The cost ... rate outpacing inflation, putting significant financial pressure on those in ... Financial. At the same time, the current economic downturn ...
... Nursing Home, Assisted Living, Home Care and Adult Day Health ... 30 The cost of long ... outpacing inflation, putting significant financial pressure on those in or ... At the same time, the current economic downturn has led ...
... Mexico Residents Access to Nursing Home, Assisted Living, ... Every Zip Code Statewide RICHMOND, Va., April 30 ... is rising at a rate outpacing inflation, putting significant financial ... annual study by Genworth Financial. At the same time, ...
... Residents Access to Nursing Home, Assisted Living, Home Care and ... StatewideRICHMOND, Va., April 30 /PRNewswire/ -- ... at a rate outpacing inflation, putting significant financial pressure on ... by Genworth Financial. At the same time, the current ...
... Assisted Living, Home Care and Adult Day Health Care Costs ... /PRNewswire/ -- The cost of long term ... inflation, putting significant financial pressure on those in or near ... At the same time, the current economic downturn has led ...
Cached Medicine News:Health News:WHO Raises Swine Flu Alert 2Health News:WHO Raises Swine Flu Alert 3Health News:WHO Raises Swine Flu Alert 4Health News:WHO Raises Swine Flu Alert 5Health News:WHO Raises Swine Flu Alert 6Health News:Growth in Ohio Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in Ohio Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in Ohio Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Growth in North Carolina Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in North Carolina Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in North Carolina Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Growth in North Carolina Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 5Health News:Growth in New Mexico Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in New Mexico Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in New Mexico Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Growth in Nevada Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in Nevada Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in Nevada Long Term Care Costs Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4Health News:Growth in Long Term Care Costs in New Jersey Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 2Health News:Growth in Long Term Care Costs in New Jersey Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 3Health News:Growth in Long Term Care Costs in New Jersey Outpacing the Rate of Inflation, According to Annual Genworth Financial Study 4
(Date:11/23/2014)... 2014 Anthera Pharmaceuticals, Inc. (Nasdaq: ... , President and Chief Executive Officer, will present a ... Conference. Anthera will present at 4:30PM ... in New York City . ... is a biopharmaceutical company focused on developing and commercializing ...
(Date:11/22/2014)... de noviembre de 2014  BioClinica®, Inc., un ... y tecnologías eClinical, ha indicado un aumento de ... para el seguimiento basado en el riesgo en ... concepto del seguimiento basado en el riesgo más ... de seguimiento o cambio de los métodos de ...
(Date:11/22/2014)... 2014 Research and Markets  has announced the ... Report, 2014-2017" report to their offering. ... recombinant protein drug market has been expanding rapidly owing ... the like. During 2005-2013, sales of recombinant protein drugs ... of 19.1%, and it is projected that ...
Breaking Medicine Technology:Anthera Pharmaceuticals to Present at Annual Piper Jaffray Healthcare Conference 2El 'seguimiento inteligente' consigue un excelente momento 2El 'seguimiento inteligente' consigue un excelente momento 3China Recombinant Protein Drug Industry Report, 2014-2017 2China Recombinant Protein Drug Industry Report, 2014-2017 3
... Studies in Mice Show Reduction of Enzyme ... -- Amicus,Therapeutics, a biopharmaceutical company developing,small-molecule, orally ... genetic diseases, announced today that the,Company will ... AT1001), Amicus' compound in development for the,treatment ...
... 2007 - Avid,Radiopharmaceuticals, Inc. (Avid), a product-focused ... the first,results from a clinical study of ... tomography (PET) imaging,of amyloid plaques in patients ... from Austin Hospital of,Melbourne, a leading investigator ...
Cached Medicine Technology:Amicus Therapeutics Presents Data From Preclinical and Phase 1,Studies of Amigal for Fabry Disease 2Amicus Therapeutics Presents Data From Preclinical and Phase 1,Studies of Amigal for Fabry Disease 3Avid Announces Results of AV-1 Molecular Imaging Agent for,Alzheimer's Disease Presented at AD/PD Meeting 2Avid Announces Results of AV-1 Molecular Imaging Agent for,Alzheimer's Disease Presented at AD/PD Meeting 3Avid Announces Results of AV-1 Molecular Imaging Agent for,Alzheimer's Disease Presented at AD/PD Meeting 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: