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UNC researchers discover gene that suppresses herpesviruses
Date:2/13/2013

With the discovery of the link between these viruses and TLKs, Dr. Damania said that researchers can begin to look for the molecular actions triggered by events like stress, and how they lead to the suppression of the TLK enzymes.

"What exactly is stress at a molecular level? We don't really understand it fully," said Dr. Damania.

With the discovery that TLKs suppresses these viruses, Dr. Damania said that the proteins can now be investigated as a possible drug target for these virus-associated cancers. In its normal function in the cell, TLKs play a role in the maintenance of the genome, repairing DNA and the assembly of the chromatin, but there is a lot more to learn about the function of the TLKs, said Dr. Damania. One avenue of her lab's future research will investigate how TLKs function in absence of the virus.

"If we prevent this protein from functioning, and we combine this with a drug that inhibits viral replication, then we could have a target to cure the cell of the virus. If the virus isn't there, the viral-associated cancers aren't present," said Dr. Damania.


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Contact: William Davis
william_davis@med.unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert  

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