Navigation Links
UNC receives NIH grant to develop and test new drugs to block HIV infection
Date:7/18/2011

CHAPEL HILL, N.C. Scientists at the University of North Carolina at Chapel Hill schools of medicine and pharmacy have been awarded a $3 million federal grant to develop and test a new generation of treatments aimed at preventing sexual transmission of HIV to uninfected individuals. This remains the most common cause of HIV infection worldwide.

The new NIAID award is entitled Next Generation Pre-Exposure Prophylaxis, or PrEP. "This project combines the strengths of four outstanding investigators with highly complementary skills, at UNC and our industrial partner, Merck," said J. Victor Garcia-Martinez, PhD, the project's principal investigator and professor of medicine, and a member of UNC's Center for Infectious Diseases and Center for AIDS Research.

Project collaborators with Garcia-Martinez are Angela Kashuba, PharmD, associate professor, and Russell Mumper, PhD, McNeill Distinguished Professor, both in the UNC Eshelman School of Pharmacy, and Daria Hazuda, PhD, at Merck Research Laboratories. Merck will not receive federal funding from this award. "We will address issues of fundamental importance to the next generation of PrEP agents," Garcia-Martinez said.

The new grant from the National Institute of Allergy and Infectious Diseases (NIAID) follows the July 11 announcement of a $32 million award from the agency to UNC to lead scientists from eight other universities in the search for ways to purge hidden HIV from the immune systems of infected patients taking antiretroviral therapy.

"This new award serves as further testament to the outstanding environment for conducting state-of-the-art AIDS research at UNC and will strengthen the close ties between our programs in medicine and pharmacy," Garcia-Martinez said.

According to Garcia-Martinez, significant progress has been made in developing measures to prevent HIV infection, but recent results of clinical trials reveal that "the level of protection observed is suboptimal and that there is significant room for further improvement."

The UNC scientist also points out that most of the trials that are ongoing now involve drugs that are used for treatment, and to which there is drug-resistance in many parts of the world. "If you use for prevention the same drug you use for treatment, you may encounter situations where drug-resistant viruses might emerge. So we need to be ahead of the virus and to start working on HIV therapies that will be available for the next generation, which is the aim of this NIH initiative."

The new project will explore candidate drugs, experimental compounds, not yet tested in people. Preclinical experiments will be conducted in humanized BLT mice. The "BLT" name is derived from the fact that these designer mice are created one at a time by introducing human bone marrow, liver and thymus tissues into animals without an immune system of their own.

Humanized BLT mice have a fully functioning human immune system and can be infected with HIV in the same manner as humans. The laboratory of Garcia-Martinez has pioneered the development of this humanized mouse model. "Prevention of sexual transmission of HIV is urgently needed," he said.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. UCSF receives $112 million to help translate science into cures
2. Wayne State University engineering student receives American Tinnitus Association award
3. Allina receives NIH grant to study real world usage of integrative therapies
4. Brookhaven Labs Joanna Fowler receives Distinguished Women in Chemistry Award
5. UH Cancer Center receives $3.58 million gift for mesothelioma research
6. UC Riverside botanist receives high honor from Howard Hughes Medical Institute
7. Illinois professor John A. Rogers receives $500,000 Lemelson-MIT Prize
8. Penn State receives $27.3 million NIH grant
9. University of Houston researcher receives grant to study water pollutants
10. Rhode Island Hospital fellow receives funding to support research in myocardial perfusion
11. Pioneering stem cell bandage receives approval for clinical trial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC receives NIH grant to develop and test new drugs to block HIV infection
(Date:8/23/2017)... ... August 23, 2017 , ... ... , has returned home to Indiana, and is now seeing patients at Boling ... ophthalmologist that specializes in the diagnosis and treatment of eye disease, medical retina, ...
(Date:8/23/2017)... ... August 23, 2017 , ... A ... of Orthopaedic Surgeons , points out that therapeutic modalities (physical therapy) is an ... According to the report, a wider scope of physical therapy options is showing ...
(Date:8/22/2017)... ... August 22, 2017 , ... Western North ... at a popular international aesthetics conference for medical professionals about the positive impact ... health and his growing practice. , Dr. George K. Ibrahim shared ...
(Date:8/22/2017)... ... August 22, 2017 , ... Five Star Glass is new to the Texas market, but ... of auto glass for most makes and models, in Grand Prairie, TX, located in the ... They have been a family owned business for the past 40 years with 32 convenient ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “Glimpses Of ... understanding of the world. “Glimpses Of Light” is the creation of published author, J.M. ... life in search of answers to life’s perplexing mysteries. , Shepherd shares, “Love is ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... MEMPHIS, Tenn. and BENTON, Ky. , Aug. 2, 2017 /PRNewswire/ ... new member to its environmental services (ES) team to proactively reduce the risk of hospital-acquired ... is a UV disinfection robot that uses UVC light energy to kill deadly pathogens such ... ... Tru-D ...
(Date:7/31/2017)... 31, 2017 Three Tru-D SmartUVC robots have arrived ... Korea . Tru-D, short for "Total Room Ultraviolet Disinfection," is a ... an environmental services (ES) professional cleans the area with traditional cleaning protocols. ... Tru-D fights germs ... "Although the BAACH has a very ...
(Date:7/27/2017)... Services, Inc. (NYSE: WST ) today announced ... financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, a record high, ... constant currency (organic) grew by 3.9%. ... in the prior-year quarter. Second-quarter 2017 adjusted diluted EPS ...
Breaking Medicine Technology: