Navigation Links
UNC physician-scientist receives grant to study breast cancer brain metastases
Date:3/25/2011

CHAPEL HILL, N.C. The American Association for Cancer Research (AACR) announced today that Carey Anders, MD, assistant professor of medicine and a member of UNC Lineberger Comprehensive Cancer Center will receive a Breast Cancer Research Foundation-AACR Grant for Translational Breast Cancer Research. The $181,000 grant will be presented at the organization's 102nd Annual Meeting, to be held in Orlando, Florida, April 2-6.

The grant will fund laboratory research to test whether a new class of drugs called PARP-inhibitors, which have successfully been used to treat other types of cancers, along with nanoparticle anti-cancer agents may be effective in treating brain metastases from triple-negative breast cancer.

Approximately 200,000 women are diagnosed worldwide each year with triple-negative breast cancer, an aggressive subset of breast cancer that lacks expression of the estrogen and progesterone receptors and the HER2 protein. This type of breast cancer is over-represented among women with advanced breast cancer.

According to Anders, recent studies show that about half of women with advanced triple-negative breast cancer experience a recurrence in the central nervous system.

"It is very frustrating as a doctor because there is no effective chemotherapy to treat breast cancer brain metastases and women who experience a recurrence in the central nervous system are frequently excluded from promising clinical trials," says Anders.

"We hope that our work will build the foundation to move forward to design clinical trials for these patients that combine PARP inhibitors in combination with nanoparticle chemotherapies aimed at improving survival for these patients," she adds.

Anders points out that this type of study would not be possible at many other institutions that do not have the laboratory models in place to accurately reproduce this type of cancer for preclinical testing of therapeutic agents. She credits the collaborative environment at UNC Lineberger and the assistance of her mentors, UNC Lineberger members Lisa Carey, MD, and Charles Perou, PhD, whose work on triple-negative breast cancer has informed the entire field.


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert  

Related medicine news :

1. Damon Runyon and Doris Duke Foundations announce partnership to support physician-scientists
2. NewYork-Presbyterian/Weill Cornell physician-scientists present at 2010 American Urological Meeting
3. Yosef Shiloh, Ph.D., receives the 51st Annual AACR G.H.A. Clowes Memorial Award
4. Susan Band Horwitz, Ph.D., receives Eighth Annual AACR Award for Lifetime Achievement in Cancer Research
5. Boston University School of Medicine professor receives award for quality of care research
6. UT MD Anderson receives grant for study of acupuncture in cancer
7. UCI jointly receives CDC grant to combat health care-associated staph infections
8. Temple receives $3.7 million to study parenting styles effect on childhood obesity
9. Stevens Dr. A. K. Ganguly receives Topliss Award Lecture from University of Michigan
10. Tufts receives patent for antibody treatment against hemolytic uremic syndrome
11. Childrens Hospital of Orange County receives largest gift in hospital history
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC physician-scientist receives grant to study breast cancer brain metastases
(Date:7/24/2017)... ... 24, 2017 , ... The 2017 NCSL International Workshop & ... focuses on the new ISO/IEC 17025 standards. This marks the first time in ... calibration will be changed. , As an exhibitor, METTLER TOLEDO will showcase ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... solution focused on delivering end-to-end sleep health care at scale, indicates record-breaking ... shows that adherence rates for positive airway pressure (PAP) therapy, the most widely ...
(Date:7/24/2017)... ... July 24, 2017 , ... A Southern California-based author has released ... abuse, and how she has overcome them. “Forbidden Memories: A Memoir,” by author Michelle ... how she has risen above. , In “Memories,” readers get a firsthand look at ...
(Date:7/24/2017)... ... July 24, 2017 , ... Committed to eliminating clubfoot as ... 100,000 children in their treatment program. Clubfoot is a pervasive problem in the ... is limited or non-existent. Without intervention, these children are destined to grow up ...
(Date:7/24/2017)... ... July 24, 2017 , ... Clinical Quality Assurance:, Roles and ... 22-23, 2017 – Arlington, VA, http://www.fdanews.com/cqa , Early bird pricing for ... growing demands to track and report adverse events place even greater pressure on ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... , July 14, 2017 Endo International plc (NASDAQ: ... on Tuesday, August 8, 2017.  Members of its senior management team ... markets open at 8:30 a.m. ET. The dial-in ... (866) 497-0462, International (678) 509-7598, and the passcode is 45397076. Please ... A replay of the call ...
(Date:7/12/2017)... July 12, 2017 CarpalAID is a revolutionary new product ... surgery. Carpal tunnel syndrome affects more than 8 million ... the rate of men. The common methods of treating CTS are ... uncomfortable hand braces or gloves. ... CarpalAID is a clear patch worn on ...
(Date:7/11/2017)... LINCOLNSHIRE, Ill. , July 11, 2017 /PRNewswire/ ... hematology and urinalysis diagnostic testing equipment as well ... latest innovation: a way to make quality assurance ... control processes. "Sysmex is well known for the ... SM Quality Monitor elevates quality assurance processes ...
Breaking Medicine Technology: