Navigation Links
UNC neuroscientists discover new 'mini-neural computer' in the brain
Date:10/27/2013

n lab at the University of North Carolina. They used patch-clamp electrophysiology to attach a microscopic glass pipette electrode, filled with a physiological solution, to a neuronal dendrite in the brain of a mouse. The idea was to directly "listen" in on the electrical signaling process.

"Attaching the pipette to a dendrite is tremendously technically challenging," Smith said. "You can't approach the dendrite from any direction. And you can't see the dendrite. So you have to do this blind. It's like fishing if all you can see is the electrical trace of a fish." And you can't use bait. "You just go for it and see if you can hit a dendrite," he said. "Most of the time you can't."

But Smith built his own two-photon microscope system to make things easier.

Once the pipette was attached to a dendrite, Smith's team took electrical recordings from individual dendrites within the brains of anesthetized and awake mice. As the mice viewed visual stimuli on a computer screen, the researchers saw an unusual pattern of electrical signals bursts of spikes in the dendrite.

Smith's team then found that the dendritic spikes occurred selectively, depending on the visual stimulus, indicating that the dendrites processed information about what the animal was seeing.

To provide visual evidence of their finding, Smith's team filled neurons with calcium dye, which provided an optical readout of spiking. This revealed that dendrites fired spikes while other parts of the neuron did not, meaning that the spikes were the result of local processing within the dendrites.

Study co-author Tiago Branco, PhD, created a biophysical, mathematical model of neurons and found that known mechanisms could support the dendritic spiking recorded electrically, further validating the interpretation of the data.

"All the data pointed to the same conclusion," Smith said. "The dendrites are not passive integrators of sensory-driven input; the
'/>"/>

Contact: Mark Derewicz
mark.derewicz@unch.unc.edu
919-923-0959
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Johns Hopkins neuroscientists win National Academy of Science Awards
2. Neuroscientists find excessive protein synthesis linked to autistic-like behaviors
3. John Templeton Foundation grant supports Princeton neuroscientists to study cognitive control
4. Discover Step-By-Step Plans On How To Learn French Fast With The “Rocket French Premium” Program – Vkoolelite
5. Discover How to Determine Baby Gender With the “Prince Or Princess” Book – Vkoolelite
6. Biosimulation Market (Drug Discovery & Development) Worth $1.2 Billion by 2017 - New Report by MarketsandMarkets
7. Tear Film Evaporation Begins at Birth Water and Health Researcher Discovers
8. New Case Management Order in New Jersey DePuy ASR Recall Litigation Extends Discovery to June 2014, More than 650 Metal Hip Lawsuits Filed in Consolidated Proceeding
9. Discover 13 Natural Tips for Whitening Skin – V kool
10. The Producers of the In View Series Announce Upcoming Airing on the Discovery Channel
11. Ethicon Transvaginal Mesh Lawsuits Move Forward, With Scheduling of Discovery Conferences in Federal Vaginal Mesh Litigation, Bernstein Liebhard LLP Reports
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC neuroscientists discover new 'mini-neural computer' in the brain
(Date:4/24/2014)... Scientists from The University of Manchester have identified a ... them more open to treatment. , The study published ... way for the development of drugs to target cells ... team made the discovery whilst exploring the possible mechanisms ... to treat breast and colon cancer. , Dr Andrew ...
(Date:4/24/2014)... April 24, 2014 ,Take me out to ... slices and kale chips. The more likely culprits include ... , Unfortunately for children who play youth baseball, ... contributing to weight problems, according to researchers at Wake ... current online edition of Childhood Obesity , found ...
(Date:4/24/2014)... corresponding terminology, and the relevance of palliation in ... on randomized controlled trials (RCTs). This is the ... for Quality and Efficiency in Health Care (IQWiG), ... , Together with external experts, IQWiG analysed studies ... cancer, malignant melanoma, and pancreatic cancer. For this ...
(Date:4/24/2014)... awarded one of 30 grants from the National Cancer ... Site in its new National Clinical Trials Network ... of investigators charged with distributing resources in a more ... system reflects recommendations from a 2010 Institute of ... goals:, Faster design, launch, and completion of ...
(Date:4/23/2014)... by Massachusetts General Hospital (MGH) investigators may lead to ... a serious medical problem use of fecal material ... the Clostridium difficile ( C. difficile ) ... the journal Clinical Infectious Diseases , the researchers ... donors unrelated to patients was as successful in curing ...
Breaking Medicine News(10 mins):Health News:Scientists find way to target cells resistant to chemo 2Health News:Take the bat, leave the candy 2Health News:Palliation is rarely a topic in studies on advanced cancer 2Health News:Palliation is rarely a topic in studies on advanced cancer 3Health News:Dartmouth awarded lead role in NCI clinical trials network 2Health News:Dartmouth awarded lead role in NCI clinical trials network 3Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 3
... theory that contemporary orgasms succor fertility found that women who ... than those that did not. The best way to get ... scientists have ascertained. ,Dr Cathy, from the School of ... age of 32. //The women were asked to go to ...
... sexual intercorse soon after delivery could jeopardize their lives. A ... occured because they indulged in sexual intercourse too soon after ... air embolisms, traveling to the heart and brain.The blood vessels ... upto 4 weeks to return to normal after birth. The ...
... females who are given a choice to select their partners ... research involves the humble fruit fly, but experts believe it ... from the University of Georgia, led by Dr Daniel Promislow, ... in a vial with one virgin female.// Some of the ...
... AIDS will surpass the Black Death as the world's worst ... AIDS do not get life prolonging drugs. The illness has ... 14,000 people are infected each day with HIV, which destroys ... living with AIDS will die, pushing the death toll beyond ...
... out a high number of operations have lower deaths rates ... a scientist at the Institute of Public Health in Cambridge, ... 12 hospitals carrying// out heart surgery on children from 1991 ... carrying out 120 open heart operations on children less than ...
... of countries where leprosy is still a health problem need ... curable disease, the World Health Organization (WHO) has said. Partners ... meeting in Brazil for their annual meeting. Brazil is one ... major public health issue. The others are India, Madagascar, Mozambique, ...
Cached Medicine News:
(Date:1/15/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ... by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), ... of Solta Medical, Inc. (NASDAQ: SLTM ) ...
(Date:1/15/2014)... Mass. , Jan. 15, 2014  Zafgen, Inc., ... unmet needs of severely obese patients, today announced ... beloranib, a selective inhibitor of methionine aminopeptidase 2 ... severe form of genetic obesity.  These results showed ...
(Date:1/14/2014)... , Jan. 14, 2014  Luminex Corporation (Nasdaq: ... for the fourth quarter of 2013 on Monday, February 3, ... release after the close of trading. (Logo: ... call to discuss the operating highlights and financial results for ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3
... 18 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: SVA),a leading developer ... it,will hold its 2010 Annual Meeting of Shareholders on Thursday, ... meeting will be held concurrently at No. 39,Shangdi Xi Road, Haidian ... St.,John,s, Antigua . All shareholders of record as of ...
... WASHINGTON , June 17 The chairman of ... the U.S. Food and Drug Administration (FDA) over its move toward ... "emergency contraceptive." In a June 17 letter to Dr. ... DiNardo of Galveston - Houston criticized the FDA,s ...
Cached Medicine Technology:Sinovac Schedules 2010 Annual Meeting of Shareholders 2Sinovac Schedules 2010 Annual Meeting of Shareholders 3Pro-Life Chair Voices 'Grave Concern' over FDA Plan to Approve Abortion Drug for 'Emergency Contraception' 2Pro-Life Chair Voices 'Grave Concern' over FDA Plan to Approve Abortion Drug for 'Emergency Contraception' 3Pro-Life Chair Voices 'Grave Concern' over FDA Plan to Approve Abortion Drug for 'Emergency Contraception' 4
... a biocompatible, flexible, one-piece artificial cornea (keratoprosthesis) ... native cornea., ,The World Health Organisation (WHO) ... 10 million people worldwide, however only 100,000 ... shortfall is due to a combination of ...
PDA application providing complex evaluation and management coding rule interactive templates....
Provides access via PDA to determine whether imaging examinations are necessary based on symptons and which studies will generate the most information....
PDA-version of the leading portable drug reference....
Medicine Products: