Navigation Links
UNC-led study documents head and neck cancer molecular tumor subtypes
Date:2/22/2013

CHAPEL HILL, N.C. - Head and neck squamous cell carcinoma (HNSCC) is the seventh most common form of cancer in the United States, but other than an association with the human papillomavirus, no validated molecular profile of the disease has been established. By analyzing data from DNA microarrays, a UNC-led team has completed a study that confirms the presence of four molecular classes of the disease and extends previous results by suggesting that there may be an underlying connection between the molecular classes and observed genomic events, some of which affect known cancer genes. The clinical relevance of the classes and certain genomic events was demonstrated, thus paving the way for further studies and possible targeted therapies.

The study was published in the Feb. 22, 2013 issue of the journal PLOS ONE.

Neil Hayes, MD, MPH, associate professor of medicine and senior author, says, "Cancer is a disease caused by alteration in the DNA and RNA molecules of tumors. A cancer results when broken molecules initiate a cascade of abnormal signals that ultimately results in abnormal growth and spread of tissues that should be under tight control within the body.

"However, most common tumors, including head and neck cancer, have relatively little information in the public record as to how these signals coordinate to create different patterns of abnormalities. This study is among the largest ever published to document reproducible molecular tumor subtypes. Subtypes, such as those we describe, represent attractive models to understand and attack cancers for treatment and prognosis."

Dr. Hayes is a member of UNC Lineberger Comprehensive Cancer Center and national co-chair of the Data Analysis Sub-Group for The Cancer Genome Atlas, a program of the National Institutes of Health.

The team, composed of investigators from UNC and five other institutions, analyzed a set of nearly 140 HNSCC samples. By searching for recurrent patterns known as gene expression signatures, they were able to detect four gene expression subtypes. The subtypes are termed basal, mesenchymal, atypical, and classical based on similarities to established gene expression subtypes in other tumor types and expression patterns of specific genes.

In spite of being the seventh most common form of cancer in the United States, HNSCC is relatively under-studied in comparison to other tumor types, e.g. breast and lung. By leveraging the similarities found in the gene expression subtypes, the results of this study provide a connection to a range of well-established findings and additional insight into the disease.


'/>"/>

Contact: Dianne Shaw
dgs@med.unc.edu
919-966-7834
University of North Carolina Health Care
Source:Eurekalert  

Related medicine news :

1. Breast Reconstruction Using Womens Own Tissue Appears Safe: Study
2. Israel rocket attacks increase miscarriage likelihood -- Ben-Gurion U. research study
3. Plastics Chemical BPA Common in Preemie ICU: Study
4. Fitness Expert Lorna Kleidman Responds to Study Claiming Exercise Can Decrease Risk of Dementia
5. Dialysis Catheters Tied to Higher Risk for Infection, Death, Study Finds
6. Should grandma join Facebook? It may give her a cognitive boost, study finds
7. Climate Change Could Affect Monarch Butterflys Migration, Study Says
8. Blood Thinners May Boost Survival for Prostate Cancer Patients: Study
9. Baylor University researchers study barriers, resources to physical activity in Texas towns
10. Study reveals new clues to Epstein-Barr virus
11. UCLA study finds endocrine disorder is most common cause of elevated calcium levels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UNC-led study documents head and neck cancer molecular tumor subtypes
(Date:1/19/2017)... ... January 18, 2017 , ... The CHP suggests that California drivers ... storm by slowing down and increasing the space between themselves and other vehicles, according ... car accident attorney Raymond R. Hassanlou notes that, rain or shine, drivers should always ...
(Date:1/19/2017)... ... January 19, 2017 , ... Connecticut Dermatology Group (CDG) ... a highly experienced and compassionate dermatologist. Dr. Kim brings an extensive background in ... “It is with considerable pleasure to welcome back Dr. Kim to the CDG team” ...
(Date:1/19/2017)... ... 19, 2017 , ... Sales Focus Inc. (SFI), a Maryland-based sales outsourcing company, ... Over the past 20 years SFI has been recognized as the world’s leader in ... clients into the US market. The new clients include: Panacea Pro, Campseekers, Contentmart, ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Infinity® Massage Chairs ... plan and implement new sales and marketing strategies. Grover comes with a total of ... 5 and a half years as Executive Vice President of Direct Sales at Traeger® ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... Osteopathic College of Proctology) announced today the opening of 3 medical offices ... http://www.hemorrhoidsremovalcenterscalifornia.com ): Hemorrhoids Center of Los Angeles (Beverly Hills), Hemorrhoids Center of ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , January 19, 2017 The global  pacemaker market ... report by Grand View Research, Inc. The heightening prevalence of cardiac conditions coupled ... growth of Pacemaker globally. In addition, technological enhancements in these devices are supporting ... ... Grand View Research Logo ...
(Date:1/19/2017)... 18, 2017  ViewRay, Inc. (Nasdaq: ... only clinical MRI-guided radiation therapy system, announced today that ... $26.1 million through a private placement of its ... the financing and was joined by certain of ... Kearny Venture Partners, and an additional new institutional ...
(Date:1/19/2017)... Jan. 18, 2017  Magnetic Insight Inc., leader ... into an agreement with inviCRO LLC to develop ... imaging system based on inviCRO,s VivoQuant™ visualization and ... as a complete MPI solution package with the ... or cell imaging in vivo. MPI ...
Breaking Medicine Technology: