Navigation Links
UNC child neurologist finds potential route to better treatments for Fragile X, autism
Date:10/23/2013

CHAPEL HILL, N.C. When you experience something, neurons in the brain send chemical signals called neurotransmitters across synapses to receptors on other neurons. How well that process unfolds determines how you comprehend the experience and what behaviors might follow. In people with Fragile X syndrome, a third of whom are eventually diagnosed with Autism Spectrum Disorder, that process is severely hindered, leading to intellectual impairments and abnormal behaviors.

In a study published in the online journal PLOS ONE, a team of UNC School of Medicine researchers led by neurologist C.J. Malanga, MD, PhD, describes a major reason why current medications only moderately alleviate Fragile X symptoms. Using mouse models, Malanga discovered that three specific drugs affect three different kinds of neurotransmitter receptors that all seem to play roles in Fragile X. As a result, current Fragile X drugs have limited benefit because most of them only affect one receptor.

"There likely won't be one magic bullet that really helps people with Fragile X," said Malanga, an associate professor in the Department of Neurology. "It's going to take therapies acting through different receptors to improve their behavioral symptoms and intellectual outcomes."

Nearly one million people in the United States have Fragile X Syndrome, which is the result of a single mutated gene called FMR1. In people without Fragile X, the gene produces a protein that helps maintain the proper strength of synaptic communication between neurons. In people with Fragile X, FMR1 doesn't produce the protein, the synaptic connection weakens, and there's a decrease in synaptic input, leading to mild to severe learning disabilities and behavioral issues, such as hyperactivity, anxiety, and sensitivity to sensory stimulation, especially touch and noise.

More than two decades ago, researchers discovered that in people with mental and behavior problems a receptor cal
'/>"/>

Contact: Mark Derewicz
mark.derewicz@unch.unc.edu
919-923-0959
University of North Carolina Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Childrens National researcher co-authors study on transitioning cystic fibrosis care
2. Bradley Hasbro Childrens Research Center launches food allergy video game trial
3. Comfort & Harmony™ Congratulates Pregnant in Heels Star Rosie Pope on Pregnancy, Expecting Fourth Child
4. St. Jude Children’s Research Hospital Scientific Director Elected to Institute of Medicine
5. Focus on developmental approach to obesity in children and adolescents
6. For low-income families, substandard housing takes toll on children
7. St. Jude Childrens Research Hospital scientific director elected to Institute of Medicine
8. Children born to teen mothers have delayed development, likely due to social factors
9. Research shows genetic anti-inflammatory defect predisposes children to lymphoma
10. Moms weight gain during pregnancy tied to childhood obesity
11. Bcureful® Aids in the Development of New Tuberous Sclerosis Complex Center at Ann & Robert H. Lurie Children’s Hospital of Chicago
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... 2014 The report segments the ... user, and geography. The equipment segment accounted for ... market, by product. However, the accessories segment is ... the forecast period, owing to the rising demand ... and ultrasound segments are the fastest-growing segments in ...
(Date:9/22/2014)... participate in athletics will be asked to sign a ... ensure parents are confident about handling the injury, according ... Hospital National Poll on Children,s Health. , In the ... and high school children surveyed reported participation in some ... read a brochure or online information, 17% have ...
(Date:9/22/2014)... and leadership of Senators Sherrod Brown (D-Ohio) and ... primary care services were lauded yesterday by the ... organizations, representing internal medicine and related subspecialties. ... for introducing the Ensuring Access to Primary Care ... will extend current-law payment rates under Medicaid for ...
(Date:9/22/2014)... 2014) The success of a colonoscopy is closely ... often resulting in missed precancerous lesions, according to new ... on Colorectal Cancer. Additionally, poor bowel cleansing can result ... to 20 to 25 percent of all colonoscopies are ... "When prescribing bowel preparation for their patients, health-care professionals ...
(Date:9/22/2014)... laser weapons, the Office of Naval Research (ONR) this ... Day Marine exposition that will prepare Marines as they ... ONR program officers will be in Booth No. 2305 ... Base Quantico, to discuss how their research contributes to ... austere and lethal." , ONR,s Expeditionary Maneuver Warfare and ...
Breaking Medicine News(10 mins):Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 2Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 3Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 4Health News:6.8% CAGR for Physiotherapy Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 5Health News:Some concussion education more useful than others, parents say 2Health News:Broad physician coalition urges Congress to extend Medicaid pay parity 2Health News:Good bowel cleansing is key for high-quality colonoscopy 2Health News:Good bowel cleansing is key for high-quality colonoscopy 3Health News:Modern Day Marine: ONR features technology for marines of the future 2
... CREEK, Calif., March 7 Longs Drug,Stores Corporation ... J. Vasos has been,named executive vice president and ... who has left the Company. Vasos will,be responsible ... Vasos joined Longs in 2001 as senior ...
... available in Spanish . , Researchers from the ... the University of Granada have carried out a ... come to is that an efficient response in primary care ... caused by three of the most frequent pathologies in older ...
... health care to be released at forum, LOS ... MAYA:, What: MAYA along with leading business and ... Better Through Communication" to,seek new ways to promote better ... and the Latino Issues Forum will release the,findings of ...
... IPC The,Hospitalist Company, Inc. (Nasdaq: IPCM ), a ... hospitalist medicine services,announced today that it will report results ... 20, 2008, before the market opens., A conference ... a.m. ET,(6:00 a.m. PT) on March 20, 2008 and ...
... Western Reserve University School of Medicine researchers published a ... Journal of Human Genetics identifying the hereditary components of ... in a Genome-wide Scan: Results from the Colon Neoplasia ... families with CRC and colon polyps in the country. ...
... physical, mental scores, study finds , , FRIDAY, March 7 ... families boosts children,s physical and mental development, a U.S. ... California, Berkeley found that children in low-income families in ... a government-run conditional cash transfer program were taller, less ...
Cached Medicine News:Health News:Longs Drug Stores Announces Todd Vasos Executive Vice President and Chief Operating Officer 2Health News:An efficient response in primary care would reduce the use of hospitals by elderly people 2Health News:Nationwide Telephone News Briefing for U.S. Health Disparities Forum 2Health News:IPC The Hospitalist Company, Inc. to Report Fourth Quarter and Year-End 2007 Financial Results 2Health News:Case Western Reserve University researchers identify colorectal cancer gene 2Health News:Government Assistance Linked to Better Child Development 2
(Date:9/22/2014)... -- Prostate cancer is the second leading cause of cancer ... caught early - the problem is that too often ... Conditions Education Council (PCEC), – a national organization ... cancer screening –  is sponsoring its 25 th ... Committed to encouraging men to take ...
(Date:9/22/2014)... , Sept. 22, 2014 CytRx Corporation ... development company specializing in oncology, today announced that study ... clinical trials of aldoxorubicin, a pivotal global Phase 3 ... a global Phase 2b clinical trial in small cell ... for Medical Oncology (ESMO) 2014 Congress being held September ...
(Date:9/19/2014)... CHAPEL HILL, N.C. , Sept. 19, 2014 ... critical role in forging relationships with key opinion ... the market and competition. Despite the critical nature ... has created many challenges, including altering the landscape ... According to research, the oversight ...
Breaking Medicine Technology:PCEC Encourages Men Across America to Have a Baseline Prostate Health Assessment During the Annual Prostate Cancer Awareness Week 2PCEC Encourages Men Across America to Have a Baseline Prostate Health Assessment During the Annual Prostate Cancer Awareness Week 3CytRx Announces Presentation of Aldoxorubicin Global Phase 3 Soft Tissue Sarcomas and Global Phase 2b Small Cell Lung Cancer Trial Designs at ESMO 2014 Congress 2CytRx Announces Presentation of Aldoxorubicin Global Phase 3 Soft Tissue Sarcomas and Global Phase 2b Small Cell Lung Cancer Trial Designs at ESMO 2014 Congress 3CytRx Announces Presentation of Aldoxorubicin Global Phase 3 Soft Tissue Sarcomas and Global Phase 2b Small Cell Lung Cancer Trial Designs at ESMO 2014 Congress 4CytRx Announces Presentation of Aldoxorubicin Global Phase 3 Soft Tissue Sarcomas and Global Phase 2b Small Cell Lung Cancer Trial Designs at ESMO 2014 Congress 5CytRx Announces Presentation of Aldoxorubicin Global Phase 3 Soft Tissue Sarcomas and Global Phase 2b Small Cell Lung Cancer Trial Designs at ESMO 2014 Congress 6Role of Medical Science Liaisons Shifting in Healthcare Industry 2
... the annual,meeting of the Pediatric Academic Societies (PAS) shows ... the start of the typical flu,vaccination season -- healthcare ... children are already in the doctor,s office.,The potential impact ... that less than 20 percent of school-aged children between ...
... May 5 N30 Pharma (N30), a,biopharmaceutical company ... that target endogenous s-nitrosothiols,announced today that it has ... with mild to moderate asthma, as well as ... treatment of reactive and,obstructive airway diseases, including Cystic ...
Cached Medicine Technology:Starting Flu Vaccination in August Could Help Protect Nearly 11 Million More Children During Scheduled Doctors' Visits 2Starting Flu Vaccination in August Could Help Protect Nearly 11 Million More Children During Scheduled Doctors' Visits 3Starting Flu Vaccination in August Could Help Protect Nearly 11 Million More Children During Scheduled Doctors' Visits 4N30 Pharma Announces Completion of Phase 1 Clinical Studies With N30-201 2
... dedicated to the principles of excellence and ... committed to aiding the clinician in early ... design of profiles and panels that provide ... tests. These tests assist to resolve the ...
ChildLab is a service of Children's Hospital, Columbus Ohio...
Millenova Immunology Laboratories is a reference laboratory dedicated to the diagnosis of immunologic causes of reproductive failure, infertility and recurrent pregnancy loss....
Marquette General Health System Reference Laboratory provides a full range of testing including, Chemistry, Hematology, Coagulation, Urinalysis, Microbiology, Cytology, Anatomic Pathology, Flow Cytom...
Medicine Products: