Navigation Links
UNC, Harvard develop inhaled TB vaccine
Date:3/14/2008

CHAPEL HILL A new tuberculosis vaccine successfully tested at the University of North Carolina at Chapel Hill is easier to administer and store and just as effective as one commonly used worldwide.

Scientists at the UNC School of Pharmacy led by Tony Hickey, Ph.D., vetted a dry powder vaccine provided by Harvard University that is administered using an inhaler. The results of the vaccine test are being published this week in the Proceedings of the National Academy of Sciences.

It is at least as good as the injectable vaccine, said Hickey, a professor in the Schools molecular pharmaceutics division. The real advantage is that this vaccine does not need to be refrigerated. It also doesnt require needles, syringes and water like the injectable vaccine, and administering it is as easy as breathing in, making it ideal for use in developing countries.

The vaccine is spray dried instead of freeze dried. Spray drying is the process of spraying a liquid through a heated gas such as nitrogen to create a powder. Traditional TB vaccines are freeze dried, requiring refrigerated storage and transportation, and a source of clean water to reconstitute the vaccine for injection. Spray dried vaccines do not need refrigeration or water to be used.

Hickeys group specializes in developing drugs and vaccines that can be inhaled as a dry powder. The vaccine used in the study was a Bacillus Calmette-Gurin (BCG) vaccine, which is not common in the United States but is used extensively throughout the world. Given to 100 million infants annually, the current BCG vaccine for TB is the worlds most widely administered childhood vaccine.

According to the Centers for Disease Control and Prevention, tuberculosis is one of the deadliest diseases, infecting a third of the worlds population. Each year nearly nine million people become sick with TB and almost two million of them die.

Hickey, who is an expert in the delivery of vaccines and medicines via dry aerosol, said that breathing in a TB vaccine is beneficial because inhalation is the way tuberculosis is contracted.

He also believes that the successful test of this vaccine could affect the development of others.

The results of this study are very exciting because there are other bacterial vaccines being developed that might benefit from this technology, he said.

Hickey is a co-founder of Oriel Therapeutics, a company developing dry-powder inhaler products to effectively deliver medicines to the lungs to treat a wide range of respiratory diseases, such as asthma and chronic obstructive pulmonary disease. He is also the founder, president and CEO of Cirrus Pharmaceuticals. Both companies are located in North Carolinas Research Triangle Park.


'/>"/>

Contact: Patric Lane
patric_lane@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Related medicine news :

1. Folic Acid in the Food Supply Reduces Birth Defects, but May Cause Extra Cancers, Reports the Harvard Womens Health Watch
2. Public Health Officials Warn About the Unrecognized Health Hazards of Smoking from a Hookah, Reports the Harvard Mental Health Letter
3. Its Time to Reassess the Value, Safety of Multivitamin Use, Says Harvard Mens Health Watch
4. Tips for Troublesome Medications, From the Harvard Heart Letter
5. High Calcium Intake May Not Help Prevent Fractures, Reports The Harvard Health Letter
6. Depression in the Elderly is Complicated but Treatable, From the Harvard Mental Health Letter
7. Hot Flashes Not Always to Blame for Sleep Problems in Menopausal Women, Reports the Harvard Womens Health Watch
8. Men Can Take Their Time to Decide on Prostate Cancer Treatment, Reports the Harvard Mens Health Watch
9. Tackling Triglycerides: 8 Ways to Solve a Big Fat Problem, From the Harvard Heart Letter
10. Millennium and Harvard Medical School Sign Cooperative Agreement for Research in Novel Field of Cancer Biology
11. Tips for Dry Winter Skin, From the Harvard Health Letter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Lafayette, California (PRWEB) , ... ... ... a pioneer in the patient payment industry today announced its strategic partnership ... and health system workflows. , The two companies’ proven, proprietary technology combine ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
Breaking Medicine Technology: