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UNC, Harvard develop inhaled TB vaccine
Date:3/14/2008

CHAPEL HILL A new tuberculosis vaccine successfully tested at the University of North Carolina at Chapel Hill is easier to administer and store and just as effective as one commonly used worldwide.

Scientists at the UNC School of Pharmacy led by Tony Hickey, Ph.D., vetted a dry powder vaccine provided by Harvard University that is administered using an inhaler. The results of the vaccine test are being published this week in the Proceedings of the National Academy of Sciences.

It is at least as good as the injectable vaccine, said Hickey, a professor in the Schools molecular pharmaceutics division. The real advantage is that this vaccine does not need to be refrigerated. It also doesnt require needles, syringes and water like the injectable vaccine, and administering it is as easy as breathing in, making it ideal for use in developing countries.

The vaccine is spray dried instead of freeze dried. Spray drying is the process of spraying a liquid through a heated gas such as nitrogen to create a powder. Traditional TB vaccines are freeze dried, requiring refrigerated storage and transportation, and a source of clean water to reconstitute the vaccine for injection. Spray dried vaccines do not need refrigeration or water to be used.

Hickeys group specializes in developing drugs and vaccines that can be inhaled as a dry powder. The vaccine used in the study was a Bacillus Calmette-Gurin (BCG) vaccine, which is not common in the United States but is used extensively throughout the world. Given to 100 million infants annually, the current BCG vaccine for TB is the worlds most widely administered childhood vaccine.

According to the Centers for Disease Control and Prevention, tuberculosis is one of the deadliest diseases, infecting a third of the worlds population. Each year nearly nine million people become sick with TB and almost two million of them die.

Hickey, who is an expert in the delivery of vaccines and med
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Contact: Patric Lane
patric_lane@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

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