Navigation Links
UMass Medical School researchers awarded pediatric HIV vaccine development grant

WORCESTER, Mass.The Elizabeth Glaser Pediatric AIDS Foundation (EGPAF), a world leader in the fight against pediatric AIDS, announced that it will award five grants totaling $1 million to researchers to support the development of a pediatric HIV vaccine.

Shan Lu, MD, PhD, professor of medicine at the University of Massachusetts Medical School (UMMS), and colleague Katherine Ruiz De Luzuriaga, MD, professor of pediatrics and director of the division of pediatric immunology, are among the first five recipient teams to receive a Pediatric HIV Vaccine Research Program grant. The UMMS team was chosen from 46 teams that competed for the grants; other awardees include researchers at Massachusetts General Hospital; Childrens Hospital Los Angeles; Beth Israel Deaconess Medical Center; and the University of Colorado Health Science Center.

The EGPAF Pediatric HIV Vaccine Research Program supports basic and pre-clinical research relevant to pediatric HIV vaccine design and development. The program was created after a survey of global HIV vaccine projects found that pediatric issues were virtually absent in the research agenda. With a global network of scientists and a long history of supporting pediatric-focused basic research, the Foundation is well positioned to address this gap.

One potentially promising way to reduce the spread of HIV is through a preventive vaccine that will protect all peopleincluding infantsfrom the virus. Vaccines have reduced many common childhood infections by up to 99 percent in the developed world, and may be the single, most effective public health measure. A vaccine that protects infants against HIV transmission through breast-feeding could set the stage for lifetime immunity. If a vaccine succeeds, millions of children could get life-long protection and be part of the first HIV-free generation.

Our awardees are remarkably talented scientists, and their projects will provide critical data that may lead to breakthroughs and inform other studies as the scientific community searches for an effective HIV vaccine, said Pamela Barnes, president and chief executive officer of the EGPAF. We formed the Pediatric HIV Vaccine Research Program to make children an integral part of vaccine research. By supporting these promising projects, we are putting a focus on children in vaccine research.

To launch this program, EGPAF requested applications from researchers across the globe for projects related to development of a pediatric vaccine. The projects selected for support will study regulatory T cells in infants; breast milk antibodies; investigate the safety and efficacy of novel vaccine candidates in animal models; study the impact of feeding from both the breast and the bottle versus breast feeding alone on the susceptibility of infants to HIV infection; and study transmitted viruses with particular focus on the cell surface proteins that allow viral entry.

The UMMS team will characterize viruses that are transmitted from HIV positive mothers to their infants and will use this information to develop vaccines that can be used to interrupt mother-to-child HIV transmission. This is the first time that HIV vaccine researchers will specifically screen and select protective antigens from mother-to-child transmitted viruses.

HIV has a protein coat (also known as the envelope protein) that interacts with cell surface proteins to allow viral entry into cells, said Dr. Luzuriaga. Antibodies to envelope proteins have been shown to protect against mother-to-child transmission in animal models. We will therefore focus on characterizing the biological properties of envelope proteins that are transmitted to infants and examine their susceptibility to neutralizing antibodies.

Information from these studies will be used to select infant viral envelope sequences for inclusion in a vaccine designed to prevent mother-to-child transmission. Recent studies conducted at UMMS have demonstrated that a novel immunization approach, in which two different forms of HIV vaccines are delivered as a sequential combination, was able to induce robust immune responses against multiple HIV isolates, said Dr. Lu. The UMMS team will use the same approach to identify virus proteins that may be able to induce antibody responses and block the transmission of HIV from mothers to children.


Contact: Office of Public Affairs
University of Massachusetts Medical School

Related medicine news :

1. UMass Medical School study finds patients diagnosed with coronary heart disease continue poor diets
2. UMass Medical School receives $300,000 from JDRF and Iacocca Foundation
3. UMass Consortium awarded $300,000 from Juvenile Diabetes Research Foundation and Iacocca Foundation
4. UMASS Medical School awarded National Childrens Study contract
5. UMass Medical School study identifies the best weight-loss plans for heart health
6. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
7. WaveMark, Inc. is Chosen by UMass Memorial Medical Center
8. Risk Management: Best Practices for Medical Device Profitability
9. Key Industry and Government Officials to Address Medical Technology Executives
10. Orqis(R) Medical Awarded 15th U.S. Patent
11. Best Practice Database Adds New Research on Effective Sales Force Incentives and Continuing Medical Education
Post Your Comments:
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
Breaking Medicine Technology: