Navigation Links
UMass Lowell researchers' findings suggest new ways to diagnose and treat Alzheimer's
Date:3/1/2010

LOWELL, Mass., March 1 A team of researchers at UMass Lowell has found a new mechanism by which a key protein associated with Alzheimer's disease can spread within the human brain.

The research, led by UMass Lowell biological sciences professor Garth Hall, gives new hope that the disease may someday be cured. It provides a new explanation of how the protein tau, a normal human protein that becomes toxic in Alzheimer's patients, can appear in their cerebrospinal fluid (CSF). The findings of the team from the UMass Lowell Center for Cellular Neuroscience and Neurodegeneration Research appear in the February issue of the Journal of Alzheimer's Disease.

"My team has discovered two different ways in which tau is secreted by neurons, or brain cells," said Hall, who has spent more than 20 years studying Alzheimer's on the cellular level using larval sea lampreys as a model system. "This might explain how tau-containing lesions seem to propagate between adjacent, interconnected parts of the brain during the development of the disease."

Until very recently, it was universally assumed by scientists that tau is never secreted from or transferred between neurons, and that CSF-tau only appears after many neurons have died and irreversible harm has been done to the brain.

"That tau secretion can occur via two distinct mechanisms strongly indicates that it is biologically 'real' and is not just tau protein leaking out of dead neurons," said Hall. "The fact that it occurs in a pattern that reproduces what is seen in the CSF of Alzheimer's patients holds out hope that patients in early stages of the disease might someday be cured. If we can distinguish secreted tau from tau that is released from dying neurons in CSF samples, then maybe we can diagnose Alzheimer's in time to stop the disease before the neurons die."


'/>"/>

Contact: Christine Gillette
Christine_Gillette@uml.edu
978-934-2209
IOS Press
Source:Eurekalert

Page: 1

Related medicine news :

1. UMass Boston Researcher, Partner Develop Non-Invasive Technique for Lead Testing in Humans
2. UMass Memorial and Bethesda Health Systems Choose Siemens Health IT
3. ACS Signs Five-Year, $100 Million Deal to Provide Technology Services to UMass Memorial Health Care, Inc.
4. UMass Medical School researchers awarded pediatric HIV vaccine development grant
5. UMass Medical School study finds patients diagnosed with coronary heart disease continue poor diets
6. UMass Medical School receives $300,000 from JDRF and Iacocca Foundation
7. UMass Consortium awarded $300,000 from Juvenile Diabetes Research Foundation and Iacocca Foundation
8. UMASS Medical School awarded National Childrens Study contract
9. UMass Medical School study identifies the best weight-loss plans for heart health
10. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
11. WaveMark, Inc. is Chosen by UMass Memorial Medical Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... 25, 2016 , ... TransactRx announces the release of enhanced ... service claims by Pharmacy Benefit Managers that were submitted by Retail Clinics and ... Cross Benefit Clearinghouse receives standard professional medical claims submitted from the retail clinic’s ...
(Date:5/25/2016)... ... May 25, 2016 , ... The University of San Francisco ... Professions. She will lead a team of more than 100 full-time faculty and staff, ... role as dean in late August. , Baker comes to USF from the University ...
(Date:5/25/2016)... FLA (PRWEB) , ... May 25, 2016 , ... ... technology to help turn back the hands of time of female aging. The ... and childbirth. Women with symptoms such as leakage, laxity, itchiness and pain have ...
(Date:5/25/2016)... Pine Brook, NJ (PRWEB) , ... May 25, 2016 , ... ... at the 2016 Annual COVD Meeting for their work on visual evoked potential and ... , summarizes recent studies that used the Diopsys® NOVA™ ERG and VEP Vision ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... builder, has announced that it will join America's leading engineers at the American ... held at the Georgia World Congress Center. , Engineers, speakers and exhibitors ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 Los innovadores ... del mundo, introduce catéteres para la intervención de ... una compañía global especializada en el suministro de ... su cartera incluyendo productos para tratar la enfermedad ... PTA son los dispositivos de primera entrada de ...
(Date:5/23/2016)... India , May 23, 2016 ... report "Patient Handling Equipment Market by Product (Wheelchair, ... of Care (Bariatric Care, Critical Care, Wound), Accessories ... - Forecast to 2021", published by MarketsandMarkets, the ... USD 17.18 Billion by 2021 at a CAGR ...
(Date:5/23/2016)... Clarifying Vision - Prospects and ... Vision Care What can be expected from ... grow at the fastest rates? This visiongain ... trends, opportunities and prospects. ,Our 190-page ... most lucrative areas in the industry and the future ...
Breaking Medicine Technology: