Navigation Links
UMass Lowell researchers' findings suggest new ways to diagnose and treat Alzheimer's

LOWELL, Mass., March 1 A team of researchers at UMass Lowell has found a new mechanism by which a key protein associated with Alzheimer's disease can spread within the human brain.

The research, led by UMass Lowell biological sciences professor Garth Hall, gives new hope that the disease may someday be cured. It provides a new explanation of how the protein tau, a normal human protein that becomes toxic in Alzheimer's patients, can appear in their cerebrospinal fluid (CSF). The findings of the team from the UMass Lowell Center for Cellular Neuroscience and Neurodegeneration Research appear in the February issue of the Journal of Alzheimer's Disease.

"My team has discovered two different ways in which tau is secreted by neurons, or brain cells," said Hall, who has spent more than 20 years studying Alzheimer's on the cellular level using larval sea lampreys as a model system. "This might explain how tau-containing lesions seem to propagate between adjacent, interconnected parts of the brain during the development of the disease."

Until very recently, it was universally assumed by scientists that tau is never secreted from or transferred between neurons, and that CSF-tau only appears after many neurons have died and irreversible harm has been done to the brain.

"That tau secretion can occur via two distinct mechanisms strongly indicates that it is biologically 'real' and is not just tau protein leaking out of dead neurons," said Hall. "The fact that it occurs in a pattern that reproduces what is seen in the CSF of Alzheimer's patients holds out hope that patients in early stages of the disease might someday be cured. If we can distinguish secreted tau from tau that is released from dying neurons in CSF samples, then maybe we can diagnose Alzheimer's in time to stop the disease before the neurons die."


Contact: Christine Gillette
IOS Press

Page: 1

Related medicine news :

1. UMass Boston Researcher, Partner Develop Non-Invasive Technique for Lead Testing in Humans
2. UMass Memorial and Bethesda Health Systems Choose Siemens Health IT
3. ACS Signs Five-Year, $100 Million Deal to Provide Technology Services to UMass Memorial Health Care, Inc.
4. UMass Medical School researchers awarded pediatric HIV vaccine development grant
5. UMass Medical School study finds patients diagnosed with coronary heart disease continue poor diets
6. UMass Medical School receives $300,000 from JDRF and Iacocca Foundation
7. UMass Consortium awarded $300,000 from Juvenile Diabetes Research Foundation and Iacocca Foundation
8. UMASS Medical School awarded National Childrens Study contract
9. UMass Medical School study identifies the best weight-loss plans for heart health
10. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
11. WaveMark, Inc. is Chosen by UMass Memorial Medical Center
Post Your Comments:
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
(Date:6/24/2016)... Washington, D.C. (PRWEB) , ... June 24, 2016 , ... ... Pro-Am Heroes Golf Classic Tournament held on June 20th at the Woodmont Country ... local charity, Luke’s Wings, an organization dedicated to helping service members that have been ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... is supporting the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. ... Scottsdale, Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says the decision ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
Breaking Medicine Technology: