Navigation Links
UMass Lowell researchers' findings suggest new ways to diagnose and treat Alzheimer's
Date:3/1/2010

LOWELL, Mass., March 1 A team of researchers at UMass Lowell has found a new mechanism by which a key protein associated with Alzheimer's disease can spread within the human brain.

The research, led by UMass Lowell biological sciences professor Garth Hall, gives new hope that the disease may someday be cured. It provides a new explanation of how the protein tau, a normal human protein that becomes toxic in Alzheimer's patients, can appear in their cerebrospinal fluid (CSF). The findings of the team from the UMass Lowell Center for Cellular Neuroscience and Neurodegeneration Research appear in the February issue of the Journal of Alzheimer's Disease.

"My team has discovered two different ways in which tau is secreted by neurons, or brain cells," said Hall, who has spent more than 20 years studying Alzheimer's on the cellular level using larval sea lampreys as a model system. "This might explain how tau-containing lesions seem to propagate between adjacent, interconnected parts of the brain during the development of the disease."

Until very recently, it was universally assumed by scientists that tau is never secreted from or transferred between neurons, and that CSF-tau only appears after many neurons have died and irreversible harm has been done to the brain.

"That tau secretion can occur via two distinct mechanisms strongly indicates that it is biologically 'real' and is not just tau protein leaking out of dead neurons," said Hall. "The fact that it occurs in a pattern that reproduces what is seen in the CSF of Alzheimer's patients holds out hope that patients in early stages of the disease might someday be cured. If we can distinguish secreted tau from tau that is released from dying neurons in CSF samples, then maybe we can diagnose Alzheimer's in time to stop the disease before the neurons die."


'/>"/>

Contact: Christine Gillette
Christine_Gillette@uml.edu
978-934-2209
IOS Press
Source:Eurekalert

Page: 1

Related medicine news :

1. UMass Boston Researcher, Partner Develop Non-Invasive Technique for Lead Testing in Humans
2. UMass Memorial and Bethesda Health Systems Choose Siemens Health IT
3. ACS Signs Five-Year, $100 Million Deal to Provide Technology Services to UMass Memorial Health Care, Inc.
4. UMass Medical School researchers awarded pediatric HIV vaccine development grant
5. UMass Medical School study finds patients diagnosed with coronary heart disease continue poor diets
6. UMass Medical School receives $300,000 from JDRF and Iacocca Foundation
7. UMass Consortium awarded $300,000 from Juvenile Diabetes Research Foundation and Iacocca Foundation
8. UMASS Medical School awarded National Childrens Study contract
9. UMass Medical School study identifies the best weight-loss plans for heart health
10. Chubby Checker Adds Twist to 10,000 Strong at Ninth Annual Walk to Cure Cancer for UMass Memorial Cancer Center at the UMass Medical School
11. WaveMark, Inc. is Chosen by UMass Memorial Medical Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... Aliso Viejo, CA (PRWEB) , ... June 25, 2017 , ... ... convert any media into an old-fashioned vintage look. FCPX LUT Vintage Volume 2 contains ... can add film grain for distorted looks, vignettes and blurs to single out subjects, ...
(Date:6/25/2017)... (PRWEB) , ... June 25, 2017 , ... An increase ... and growing foliage and plants, and along with that; a humdinger of an allergy ... sufferers, it also means an increase in misery-causing grass and weed pollen. , ...
(Date:6/25/2017)... ... , ... June is Men’s Health Month and the focus is on prostate cancer. ... the U.S. and the third most common cause of cancer related death today; lung cancer ... will be diagnosed with prostate cancer during his lifetime. Those at highest risk ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. Mitchell Mehlman and ... in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine and emergency dental ... dentist fit into their patients’ busy lifestyles. Dental365 also gladly work with most ...
(Date:6/23/2017)... RI (PRWEB) , ... June 23, 2017 , ... ... Care Network today announced the launch of Care Management Alerts and Dashboards, an ... 140,000 patients throughout Rhode Island. , RIQI’s Care Management Alerts and Dashboards provide ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... BELL, Pa. , June 1, 2017 ... (PRN) and Veterinarian Recommended Solutions (VRS), and KD Pharma ... investment in Nutriceutical Holdings by KD Pharma Group. KD ... Holdings with the option to acquire the entire company. ... partner in KD. They are committed to growing the ...
(Date:5/29/2017)... -- Cellect Biotechnology Ltd. (NASDAQ: APOP ; TASE: APOP), ... selection of stem cells, today provided a corporate update ... March 31 st , 2017. "We ... quarter of 2017," said Dr. Shai Yarkoni, Chief Executive ... of the first blood cancer patient in the recently ...
(Date:5/23/2017)...  Leaf Healthcare, recognized for developing one of ... ulcer prevention, will unveil its comprehensive mobility monitoring ... Nurses, National Teaching Institute and Critical Care Exposition ... Patient Monitoring System is the first mobility monitoring ... system seamlessly tracks patient movement throughout the mobility ...
Breaking Medicine Technology: